The Prodrug Platin‐<i>A</i>: Simultaneous Release of Cisplatin and Aspirin

Pathak, Rakesh; Marrache, Sean; Choi, Joshua H.; Berding, Trenton B.; Dhar, Shanta

doi:10.1002/anie.201308899

Cited by 243 publications

(174 citation statements)

References 30 publications

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“…[12][13][14][15] Therefore, much effort has been made to overcome the side effects and improve the antitumor activity of platinum-based drugs. [16][17][18][19] Oxaliplatin, one of the best sale anticancer drugs, has become the standard first line therapy in case of metastatic colorectal cancer, which can exhibit activity against cisplatin and carboplatin resistant cancers. 20 It is noted that oxaliplatin possesses a cycloalkyl framework, 1R,2R-diaminocyclohexane (abbreviated as 1R,2R-DACH), which acts as a carrier ligand providing steric hindrance when interacting with DNA.…”

Section: Introductionmentioning

confidence: 99%

Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance

et al. 2015

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A series of platinum(II) complexes, characteristic of chiral trans-bicyclo[2.2.2]octane-7,8-diamine as ligand possessing dicyclic steric hindrance, were designed and synthesized. Biological evaluation showed that almost all complexes had cytotoxic activity against the tested cancer cell lines, among which most of chiral (R,R)-enantiomeres had stronger cytotoxicity than their (S,S)-counterparts, and 2a, [trans-bicyclo[2.2.2]octane-7R,8R-diamine](oxalato-O,O')platinum(II), is the most effective agent. Significantly, its counterpart, 2b, was much more sensitive to cisplatin resistant SGC7901/CDDP cancer cell line at a higher degree than 2a. Docking study and agarose gel electrophoresis revealed that the interaction of 2a with DNA was similar to that of oxaliplatin. Western blot analysis demonstrated that 2a could induce a better effect than cisplatin on a mitochondrial-dependent apoptosis pathway. Kinetic study indicated that the dicyclic ligand can accelerate the reaction rate of the complex.

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Section: Introductionmentioning

confidence: 99%

Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance

et al. 2015

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“…[6] Many studies have reported on dual therapies that treat both inflammation and cancer,b ut few studies have focused directly on inflammation caused by PTT. [7] Among av ast array of nanomaterials,A uNRs offer ease of preparation, ready multi-functionalization and efficient conversion of NIR optical energy into heat. [8] Nevertheless,it is necessary to improve the thermostability of AuNRs in order to extend their biomedical applications during prolonged laser irradiation.…”

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confidence: 99%

Simultaneous Application of Photothermal Therapy and an Anti‐inflammatory Prodrug using Pyrene–Aspirin‐Loaded Gold Nanorod Graphitic Nanocapsules

et al. 2017

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Photothermal therapy( PTT) has been extensively developed as an effective approach against cancer.H owever, PTT can trigger inflammatory responses,i nt urn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was developed to deliver enhanced PTT and simultaneously inhibit PTT-induced inflammatory response.1 -Pyrene methanol was utilizet os ynthesize the anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with ac leavable ester bond and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), ap hotothermal agent, through p-p interactions. Such AuNR@G-P-aspirin complexes were used for nearinfrared laser-triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT-induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects in vitro and in vivo.

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“…However, the human pharmacokinetic studies revealed that from 25 to 45 % of intravenously injected cisplatin is excreted in the urine, while the rest is distributed throughout the body [39,40]. Hence, small quantities, in the order of ppb ( μ g/l) or possibly ppt (0.001 ng/l) are able to reach tumoral cells [41][42][43].…”

Section: Survey Of Results and Discussionmentioning

confidence: 99%

Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma

González‐Torres¹,

Torres²,

Torres³

et al. 2017

ChChT

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Abstract.1 Cis-diaminedichloroplatinum(II), also known as cisplatin, has been quantified by use of inductivelycoupled plasma. We measured cisplatin indirectly by determining the platinum concentration in the samples. We focus on the determination of Pt from cisplatin in water. We demonstrate that the total concentration of the drug can be quantified through the content of platinum with acceptable linearity, precision, repeatability, accuracy, limit of detection and limit of quantification. Our method is applicable among others for monitoring quality of control samples for cisplatin regulatory submissions and for determination of the cisplatin release profiles in biomarker implants in vitro.

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The Prodrug Platin‐A: Simultaneous Release of Cisplatin and Aspirin

Cited by 243 publications

References 30 publications

Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance

Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric Hindrance

Simultaneous Application of Photothermal Therapy and an Anti‐inflammatory Prodrug using Pyrene–Aspirin‐Loaded Gold Nanorod Graphitic Nanocapsules

Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma

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