The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2.

Law, Martha Liao; Kao, Fa‐Ten; Wei, Qi; Hartz, Judith A.; Greene, Geoffrey L.; Zarucki-Schulz, Tanya; Conneely, Orla M.; Jones, Carol; Puck, Theodore T.; Bw, O’Malley

doi:10.1073/pnas.84.9.2877

Cited by 51 publications

(16 citation statements)

References 43 publications

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“…The present study suggests that amplification of the 1 1q13 region in breast cancer occurs in a quite different subset of tumours than affected by HER-2/neu amplification, a conclusion also drawn by Adnane et al (1989) (Law et al, 1987) mapped to the same chromomsomal site as INT2. The location of the PgR gene was, however, later revised to a more distal site on the long arm (1 lq22-q23, Rousseau-Merck et al, 1987.…”

Section: Discussionsupporting

confidence: 69%

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

Borg

Sigurðsson²,

Clark³

et al. 1991

Br J Cancer

116

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Section: Discussionsupporting

confidence: 69%

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

Borg

Sigurðsson²,

Clark³

et al. 1991

Br J Cancer

116

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“…However, luteal mRNA for 3␤HSD declines dramatically during early pregnancy despite increased luteal progesterone synthesis (35,37). These changes in 3␤HSD mRNA levels are similar to those reported in macaque CL during the luteal phase (45,46) and simulated early pregnancy (55). Although LH is essential for the maintenance of steroidogenic enzymes in macaque CL (46), CG production during early pregnancy did not maintain the mRNA for 3␤HSD.…”

Section: Discussionsupporting

confidence: 65%

Expression of Steroid Receptors and Steroidogenic Enzymes in the Baboon (Papio anubis) Corpus Luteum during the Menstrual Cycle and Early Pregnancy1

Hild-Petito

Fazleabas

1997

The Journal of Clinical Endocrinology &Amp; Metabolism

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As estrogen and progesterone are proposed regulators of luteal function, this study was undertaken to correlate the presence of receptors for these steroids with luteal function during early pregnancy. Corpora lutea (CL) were obtained from nonpregnant baboons during the midluteal [ML; days 7-8 postovulation (PO)] and late luteal (LL; days 11-12 PO) phases of the menstrual cycle or from pregnant baboons on days 18, 25, 29, or 31-33 PO. Estrogen and progestin receptors (ER and PR, respectively) and 3␤-hydroxysteroid dehydrogenase (3␤HSD) were detected by immunocytochemistry using specific monoclonal (H222 for ER; JZB39 for PR) or polyclonal (S683 for 3␤HSD) antibodies. In addition, ribonucleic acid (RNA) was extracted from CL, processed for Northern blot analysis, and probed with complementary DNAs to human PR, human 3␤HSD, and rat aromatase. Levels of messenger RNA (mRNA) for 3␤HSD were quantified by laser densitometric scanning, and the data were normalized to the expression of a housekeeping gene (glyceraldehyde-3-phosphate dehydrogenase) to correct for loading differences. CL did not demonstrate specific nuclear stain for ER at any stage of the menstrual cycle or pregnancy. In contrast, PR-positive cells were present during the ML phase, but decreased during the LL phase (P Ͻ 0.05). PR-positive cells were maintained during early pregnancy at levels comparable to the ML phase (P Ͼ 0.05). Staining for 3␤HSD was present at all stages of the cycle and pregnancy. Although the percent of 3␤HSD-positive cells appeared to decrease as pregnancy proceeded, this was not statistically different (P Ͼ 0.05). The complementary DNA to PR hybridized to multiple transcripts (ϳ4.4, 3.1, 1.6, and 0.95 kilobases) in CL of the cycle. A single transcript (ϳ1.8 kilobases) for 3␤HSD was present in CL at all stages of the cycle and pregnancy. The level of 3␤HSD mRNA was highest during the ML phase and declined significantly (P Ͻ 0.05) during the LL phase and early pregnancy. Three transcripts (ϳ3.6, 3.0, and 1.7 kilobases) for aromatase were detected in CL of the cycle and pregnancy. Aromatase mRNA increased during early pregnancy. These results support the concept of PR-mediated events, but not ER-regulated processes in the primate CL. Furthermore, the data suggest that the steroidogenic enzymes 3␤HSD and aromatase are differentially regulated during early pregnancy. (J Clin Endocrinol Metab 82: [955][956][957][958][959][960][961][962] 1997) I N PRIMATES, LH is clearly required to sustain progesterone secretion by the corpus luteum (CL). In addition, it has been proposed that estrogen and progesterone may play a paracrine or autocrine role in regulating luteal function. In rats and rabbits, estrogen is luteotropic (1); however, estrogen induces luteolysis in women and rhesus monkeys (2, 3) when administered exogenously. As estrogen treatment was unable to cause luteolysis in monkeys whose gonadotropin secretion was controlled by the administration of pulsatile GnRH (4), the luteolytic effect of exogenous estrogen is presuma...

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“…After in situ hybridization with normal metaphase chromosomes, our data were inconsistent with those of Law et al (1987a). who localized PGR on band q 13 of chromosome 11.…”

Section: Precise Localization O F the Different Probes Using Chromosocontrasting

confidence: 56%

Fine mapping of the long arm of human chromosome 11 by in situ hybridization using different translocations, including the t(11;22) of Ewing sarcoma

Bérubé

Passage

Matteï

et al. 1990

Cytogenet Genome Res

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The progesterone receptor gene (PGR), the gene coding for porphobilinogen deaminase (PBGD), the gene coding for a neural cell adhesion molecule (NCAM), the oncogene ETS1, and the anonymous genomic sequence D11S29 have been previously located on the long arm of chromosome 11. However, gene localizations obtained with different gene-mapping procedures have led to occasional discrepancies. To localize these genes more precisely, we hybridized five human DNA sequences with different chromosomal rearrangements, including four balanced and one unbalanced translocations. We show here that the order of these five sequences is cen PGR-PBGD-D1 lS29/NCAM/ETSl-tel.

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The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2.

Cited by 51 publications

References 43 publications

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

Expression of Steroid Receptors and Steroidogenic Enzymes in the Baboon (Papio anubis) Corpus Luteum during the Menstrual Cycle and Early Pregnancy1

Fine mapping of the long arm of human chromosome 11 by in situ hybridization using different translocations, including the t(11;22) of Ewing sarcoma

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