The prognostic factors of resected non-small cell lung cancer with chest wall invasion

Lee, Chang Young; Byun, Chun Sung; Lee, Jin Gu; Kim, Dae Joon; Cho, Byoung Chul; Chung, Kwansoo; Park, In Kyu

doi:10.1186/1477-7819-10-9

Cited by 37 publications

(52 citation statements)

References 20 publications

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“…This number differs from the data reported by Chapelier et al in 2000 and Lee et al in 2012, who observed a median survival time of 15.9 and 18 months, respectively [13,22]. However, Suzuki et al [23] reported a mean follow-up time of 49.3 months (range, 1 to 207 months).…”

Section: Discussionmentioning

confidence: 57%

“…However, the cumulative survival rates at 5 years reported by Lee et al [13] and Kawaguchi et al [6] for cohorts who underwent the different surgical techniques were 26.3% and 44.9%, respectively. Several factors have an impact on the survival of NSCLC patients, of which mediastinal lymphadenopathy is regarded as one of the most important [3,28].…”

Section: Discussionmentioning

confidence: 99%

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Lung cancer with chest wall invasion: retrospective analysis comparing en-bloc resection and ‘resection in bird cage’

Santos

Lopes

Higa

et al. 2014

J Cardiothorac Surg

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BackgroundInvasion of the chest wall per se is not a contraindication for tumor resection in non-small cell lung cancer (NSCLC), provided there is no mediastinal lymph node or vital structure involvement. Although widely known to Brazilian surgeons, the ‘resection in bird cage’ technique has never been widely studied in terms of patient survival. Thus, the objective of this study was to evaluate the postoperative consequences and overall survival of extra-musculoperiosteal resection compared with en-bloc resection in NSCLC patients with invasion of the endothoracic fascia.MethodsBetween January 1990 and December 2009, 33 NSCLC patients with invasion of the thoracic wall who underwent pulmonary resection were retrospectively analyzed. Of the 33 patients evaluated, 20 patients underwent en-bloc resection and 13 underwent ‘resection in bird cage.’ For each patient, a retrospective case note review was made.ResultsThe median age at surgery, gender, indication, rate of comorbidities, tumor size and the degree of uptake in the costal margin were similar for both groups. The rate of postoperative complications and the duration of hospitalization did not differ between the groups. Regarding the outcome variables, the disease-free interval, rate of local recurrence, metastasis-free time after surgery, overall mortality rate, mortality rate related to metastatic disease, duration following surgery in which deaths occurred, and overall survival were also similar between groups. The cumulative survival curves between the ‘resection in bird cage’ and en-bloc resection and between stages Ia + Ib and IIb + IIIa + IV were not significantly different (p = 0.68 and p = 0.64, respectively). The cumulative metastasis-free survival curves were not significantly different between the two types of surgery (p = 0.38).ConclusionsIn NSCLC patients with invasion of the endothoracic fascia, ‘resection in bird cage’ is a less aggressive procedure that yields similar results in terms of morbidity and mortality compared with en-bloc resection. Thus, ‘resection in bird cage’ meets the oncologic principles of resection and does not adversely affect the patients in terms of cure.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Lung cancer with chest wall invasion: retrospective analysis comparing en-bloc resection and ‘resection in bird cage’

Santos

Lopes

Higa

et al. 2014

J Cardiothorac Surg

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“…[4]. Однако ряд авторов сообщают о влиянии глубины инвазии на продолжитель-ность жизни больных [5,6].…”

Section: Discussionunclassified

Results of surgical treatment in patients with non-small cell lung cancer with tumor ingrowth into the chest

Пикин¹,

Trakhtenberg²,

Ryabov³

et al. 2016

Onkol. Z. im. P.A. Gercena

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39 Опыт рабОтыВовлечение париетальной плевры, мягких тканей и/или костных структур грудной стенки у пациентов с резектабельным немелкоклеточным раком легкого (НМРЛ), по данным разных авторов, составляет 5-8% [1,2]. Результаты консервативных методов лечения этой группы больных остаются неудовлетворительными. C тех пор как F. Coleman [3] показал техническую возможность выполнения резекции грудной стенки в случае ее вовлече-ния при раке легкого, а также несколько случаев удовлет-ворительных отдаленных результатов у пациентов данной группы, было опубликовано несколько исследований, по-священных этой проблеме.В целом отдаленные результаты лечения этой группы больных остаются неудовлетворительными, что требует изучения роли различных прогностических факторов и их влияния на общую и безрецидивную выживаемость. Цель -изучение результатов хирургического лечения больных немелкоклеточным раком легкого с врастанием опухоли в грудную стенку. Материал и методы. С 1980 г. в МНиои им. П.А. Герцена проведено хирургическое лечение 68 больным немелкоклеточным раком легкого с прорастанием опухоли в грудную стенку. По данным гистологического исследования у 34 пациентов метастазов во внутригрудных лимфатических узлах не было (N0), у 9 пациентов выявлены метастазы в лимфатических узлах корня легкого или бронхопульмональной группы (N1), у 25 пациентов -в средостенных лимфа-тических узлах (N2). хирургическое лечение в объеме лобэктомии с резекцией грудной стенки выполнено у 50 больных, билобэктомия с резекцией грудной стенки -у 2, пневмонэктомия -у 16 больных. операции паллиативного характера выполнены у 7 больных. Результаты. 5-летняя выживаемость больных при N0, N1 и N2 составила соответственно 41, 18 и 7%. При паллиативном характере операции ни один пациент не пережил этот срок. Анализ прогностических факторов по-зволяет выделить наиболее значимые: состояние внутригрудных лимфатических узлов и характер выполненной операции (радикальная или паллиативная). Заключение. отдаленные результаты хирургического лечения немелкоклеточного рака легкого с прорастанием опухоли в грудную стенку при интактных лимфатических узлах удовлетворительные: более 40% пациентов переживают 5 лет наблюдения. Паллиативный характер операции и метастазы в средостенных лимфатических узлах предопределяют плохой прогноз. Objective: to study the results of surgical treatment in patients with non-small cell lung cancer with tumor ingrowth into the chest. Subjects and methods. Sixty-eight patients with non-small cell lung cancer with tumor ingrowth into the chest have been surgically treated at the P.A. herzen Moscow oncology Research institute since 1980. histological examination showed that 34 patients had no intrathoracic lymph node metastases (N 0 ), 9 had metastases in the lung root and bronchopulmonary lymph nodes (N 1 ), and 25 had those into mediastinal ones (N 2 ). Surgery as lobectomy with chest wall resection was performed in 50 patients, bilobectomy with chest wall resection in 2, and pneumonectomy in 16 patients. Palliative surgery was done in 7 patients. R...

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“…NSCLC patients, particularly in the case of chest wall invasion (Doddoli et al, 2005;Wakelee et al, 2005;Lee et al 2012;Mantovani et al, 2012).…”

Section: 7559 Number Of Mediastinal Lymph Nodes As a Prognostic Factmentioning

confidence: 99%

Number of Mediastinal Lymph Nodes as a Prognostic Factor in PN2 Non Small Cell Lung Cancer: A Single Centre Experience and Review of the Literature

Takanen

Bangrazi²,

Graziano³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Currently the most important prognostic factor in lung cancer is the stage. In the current lung TNM classification system, N category is defined exclusively by anatomic nodal location though, in other type of tumours, number of lymph nodes is confirmed to be a fundamental prognostic factor. Therefore we evaluated the number of mediastinal lymph nodes as a prognostic factor in locally advanced NSCLC after multimodality treatment, observing a significant effect of the number of lymph nodes in terms of OS (p<0.01) and DFS (p<0.001): patients with a low number of positive mediastinal nodes have a better prognosis.

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The prognostic factors of resected non-small cell lung cancer with chest wall invasion

Cited by 37 publications

References 20 publications

Lung cancer with chest wall invasion: retrospective analysis comparing en-bloc resection and ‘resection in bird cage’

Lung cancer with chest wall invasion: retrospective analysis comparing en-bloc resection and ‘resection in bird cage’

Results of surgical treatment in patients with non-small cell lung cancer with tumor ingrowth into the chest

Number of Mediastinal Lymph Nodes as a Prognostic Factor in PN2 Non Small Cell Lung Cancer: A Single Centre Experience and Review of the Literature

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