The Prognostic Impact of Eosinophils and the Eosinophil-to-Lymphocyte Ratio on Survival Outcomes in Stage II Resectable Pancreatic Cancer

Ohkuma, Ryotaro; Kubota, Yutaro; Horiike, Atsushi; Ishiguro, Tomoyuki; Hirasawa, Yuya; Ariizumi, Hirotsugu; Watanabe, Makoto; Onoue, Rie; Ando, Kiyohiro; Tsurutani, Junji; Yoshimura, Kiyoshi; Aoki, Takeshi; Murakami, Masahiko; Kobayashi, Shinichi; Tsunoda, Takuya; Wada, Satoshi

doi:10.1097/mpa.0000000000001731

Cited by 14 publications

(16 citation statements)

References 38 publications

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“…With respect to ELR, Ohkuma R, et a. [24] found that low ELR was an independent prognostic factor of clinical outcome in stage II resectable pancreatic cancer. [24] In AECOPD, ELR was a potential indictor of eosinophilic airway in ammation [25].…”

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confidence: 98%

Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR), and eosinophil-to-lymphocyte ratio (ELR) as biomarkers in patients with acute exacerbation chronic obstructive pulmonary disease

Liao¹,

Mo²,

Zhu³

et al. 2023

Preprint

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The study comprehensively evaluated the prognostic roles of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio. (MLR), basophil-to-lymphocyte ratio (BLR) and eosinophil-to-lymphocyte ratio (ELR) in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). 619 patients with AECOPD and 300 healthy volunteers were retrospectively included into the study. The clinical characteristics containing laboratory findings of the AECOPD patients and the complete blood counts (CBCs) of the healthy volunteers were collected. Compared with the healthy volunteers, PLR, NLR, MLR, BLR, and ELR were all elevated in COPD patients under stable condition. PLR, NLR, MLR, and BLR were further elevated while ELR was lowered during exacerbation. PLR, NLR, and MLR were all positively correlated with hospital LOS as well as CRP. In contrast, ELR was negatively correlated with hospital LOS as well as CRP. Elevated PLR, NLR, and MLR were all associated with more serious airflow limitation in AECOPD. Elevated PLR, NLR, and MLR were all associated with increased in-hospital mortality while Elevated ELR was associated with decreased in-hospital mortality. Binary logistic regression analysis showed that smoking history, FEV1% predicted, pneumonia, pulmonary heart disease (PHD), uric acid (UA), albumin, and MLR were significant independent predictors for in-hospital mortality. These predictors along with ELR were used to construct a nomogram predicting in-hospital mortality in AECOPD. The nomogram had a C-index of 0.850 (95% CI: 0.799–0.901), and its good predictive value and clinical applicability were summary further demonstrated. In summary, PLR, NLR, MLR, and ELR served as biomarkers in patients with AECOPD.

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confidence: 98%

Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR), and eosinophil-to-lymphocyte ratio (ELR) as biomarkers in patients with acute exacerbation chronic obstructive pulmonary disease

Liao¹,

Mo²,

Zhu³

et al. 2023

Preprint

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“…Previous studies demonstrated that high levels of tumor-infiltrating eosinophils are positively associated with better prognosis, inversely correlated with stage and related to decreased risk of death caused by cancer progression [ 32 , 33 ]. Furthermore, a low number of eosinophils is related with short overall survival and seems to be an independent prognostic factors for poor outcomes in patients with pancreatic cancer [ 34 ]. Eosinophils are a major component of the type II immune response and are capable of secreting many factors such as cytotoxic granules, lipids, growth factors, cytokines and chemokines.…”

Section: Discussionmentioning

confidence: 99%

Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils

2022

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Background Immunotherapy of gastrointestinal cancers is challenging; however, several lines of evidence suggest that adoptive transfer of stimulated or modified immune cells support not only protective role of immune cells in tumor microenvironment, but actively participate in the elimination of cancer cells. Methods In vivo studies employing cancer cell-derived allograft murine models of gastrointestinal cancers were performed. The effects of T helper (Th) 2 cells on gastrointestinal cancers growth and tumor microenvironment composition using adoptive transfer of Th2 cells, interleukin (IL)-5 treatment, and immunofluorescence, multiplex and real-time PCR were explored. Results Here, we show that Th2 cells play an essential role in the inhibition of colon and pancreas cancers progression. In murine models of gastrointestinal tumors using adoptive transfer of Th2 cells, we identify that Th2 cells are responsible for generation of apoptotic factors and affect macrophage as well as eosinophil recruitment into tumors where they produce cytotoxic factors. Moreover, we found that Th2 cells lead to IL-5 hypersecretion, which links the anti-tumorigenic function of Th2 cells and eosinophils. Importantly, we noted that recombinant IL-5 administration is also related with inhibition of gastrointestinal tumor growth. Finally, using an in vitro approach, we documented that both Th2 cells and eosinophils are directly responsible for gastrointestinal cancer cell killing. Conclusions These data demonstrate the significance of Th2 cells, eosinophils and IL-5 in the inhibition of gastrointestinal tumor growth, and pointed toward tumor microenvironment reprogramming as a Th2 cell-mediated anti-tumorigenic mechanism of action.

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“…Consequently, ELR has been considered as a systemic inflammatory indicator. Prior studies reported that there was a significant relationship between ELR and adverse events in patients with malignancy [6,7]. Moreover, Yılmaz et al recently found that subjects with angiographic isolated CAE had significantly greater ELR values [8].…”

Section: ) or -Odds Ratio CI -Confidence Interval Ht -Hypertension Hd...mentioning

confidence: 97%

“…The eosinophil-to-lymphocyte ratio (ELR) is a new inflammatory bioindex that takes into account both eosinophil and lymphocyte levels [6]. In recent studies, the relationship between the ELR and adverse events in patients with malignancy has been demonstrated [6,7]. Besides that, the predictive value of this index has been investigated for isolated coronary artery ectasia presence and severity [8].…”

Section: Introductionmentioning

confidence: 99%

Association of eosinophil-to-lymphocyte ratio with coronary slow-flow phenomenon in patients undergoing coronary angiography

Tosu

Kalyoncuoğlu

Biter

et al. 2022

Arch Med Sci Atheroscler Dis

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IntroductionThe current investigation intended to evaluate the correlation between eosinophil-to-lymphocyte ratio (ELR) and the coronary slow-flow phenomenon (CSFP) in patients undergoing elective coronary angiography.Material and methodsA case-control investigation was conducted on 200 individual CSFP patients and another 200 individuals with normal coronary arteries and who were matched for age, gender, and body mass index. ELR was computed by dividing the number of eosinophils by the number of lymphocytes. Thrombolysis in myocardial infarction frame count was used to determine the CSFP.ResultsThe ELR in the CSFP group was substantially greater than in the control group [0.38 (0.28–0.50)] and [0.22 (0.17–0.35)], p < 0.001, respectively). With the help of multivariable logistic regression analysis, ELR independently predicted the CSFP presence (odds ratio = 1.040, 95% CI: 1.026–1.053), p < 0.001). The effective cutoff point of ELR in predicting CSFP presence was > 0.29 with sensitivity of 77% and specificity of 70%. ELR had better diagnostic accuracy to predict CSFP than either lymphocyte or eosinophil count alone [AUC = 0.746 vs. AUC = 0.687 vs. AUC = 0.687, respectively].ConclusionsTo our knowledge, this was the first investigation to determine the connection between ELR and CSFP. We discovered that individuals with CSFP had higher ELR than those with normal coronary arteries in the control group.

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The Prognostic Impact of Eosinophils and the Eosinophil-to-Lymphocyte Ratio on Survival Outcomes in Stage II Resectable Pancreatic Cancer

Cited by 14 publications

References 38 publications

Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR), and eosinophil-to-lymphocyte ratio (ELR) as biomarkers in patients with acute exacerbation chronic obstructive pulmonary disease

Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR), and eosinophil-to-lymphocyte ratio (ELR) as biomarkers in patients with acute exacerbation chronic obstructive pulmonary disease

Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils

Association of eosinophil-to-lymphocyte ratio with coronary slow-flow phenomenon in patients undergoing coronary angiography

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