The prognostic role of indicators of systemic inflammatory response in patients with glioblastoma

Kaya, Veli; Yıldırım, Mustafa; Yazıcı, Gözde; Yalçın, Ayşen Yeşim; Orhan, Nuri; Güzel, Aslan

doi:10.1093/annonc/mdx366.026

Cited by 16 publications

(35 citation statements)

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“…In total, 3,261 patients diagnosed with glioma from 18 studies were included . All of the included studies were published in recent years and were from seven different countries, which were retrospectively designed with 17 single‐center trialsand one multicenter trial . There were 15 studies performed multivariate Cox regression analysis and reported adjusted HR .…”

Section: Resultsmentioning

confidence: 99%

“…All of the included studies were published in recent years and were from seven different countries, which were retrospectively designed with 17 single‐center trialsand one multicenter trial . There were 15 studies performed multivariate Cox regression analysis and reported adjusted HR . The main features of the selected studies are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…In the analysis of the NLR for predicting the prognosis of gliomas, 15 studies ( n = 2,798 patients) were included. The patients with a higher pre‐operative NLR had a worse prognosis (HR: 1.38; 95% CI: 1.09–1.74; P = 0.008; Figure a ).…”

Section: Resultsmentioning

confidence: 99%

“…Neutrophils are the most abundant white blood cells and are the first to be recruited to inflammatory sites . Furthermore, inflammatory cytokines or reactive oxygen species secreted by tumor cells cause the neutrophil count to increase, both in tumor stroma and in peripheral blood . The blood‐brain barrier is easily impaired in many neurologic tumors, resulting in an easy infiltration of monocytes.…”

Section: Discussionmentioning

confidence: 99%

“…An elevated number of circulating and infiltrating neutrophils is influenced by glioma‐derived factors that can directly promote the proliferation of GBM cells by upregulating S100A4 . The increase in the neutrophil count may cause a decrease in lymphocytes and lymphocyte apoptosis . This interaction between neutrophils and lymphocytes in response to inflammation is of significance in immunosuppression .…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta‐Analysis

Wang¹,

Kang

Lin

et al. 2019

Clinical Translational Sci

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Glioma is the most common malignant brain tumor and has high lethality. This tumor generated a robust inflammatory response that results in the deterioration of the disease. However, the prognostic role of systemic cellular inflammatory indicators in gliomas remains controversial. This meta‐analysis aimed to assess the prognostic significance of preoperative neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), red cell distribution width (RDW), and prognostic nutritional index (PNI) in patients with gliomas. Databases of PubMed, EMBASE, Web of Science, and The Cochrane Library were systematically searched for all studies published up to January 2019. Study screening and data extraction followed established Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. The Newcastle–Ottawa Scale was used to assess the quality of studies. Eighteen studies containing 3,261 patients were included. The analyses showed an increased NLR or RDW was found to be an independent predictor of worse survival in patients with gliomas (hazard ratio (HR): 1.38; 95% confidence interval (CI): 1.09–1.74; P = 0.008; and HR: 1.40; 95% CI: 1.13–1.74; P = 0.002, respectively). Furthermore, a higher PNI indicates a better overall survival (OS; HR: 0.57; 95% CI: 0.42–0.77; P = 0.0002). For the evaluation of PLR and LMR, none of these variables correlated with OS (P = 0.91 and P = 0.21, respectively). Our meta‐analysis indicates the NLR, RDW, and PNI rather than PLR and LMR are the independent index for predicting the OS of gliomas. Pre‐operative NLR, RDW, and PNI can help to evaluate disease progression, optimize treatment, and follow‐up in patients with gliomas.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta‐Analysis

Wang¹,

Kang

Lin

et al. 2019

Clinical Translational Sci

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Immuno markers in newly diagnosed glioblastoma patients underwent Stupp protocol after neurosurgery: a retrospective series

et al. 2023

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Purpose The aims of our retrospective study investigated the role of immune system in glioblastoma (GBM), which is the most aggressive primary brain tumor in adults characterized by a poor prognosis. The recurrence rate remains high, probably due to “immune-desert” tumor microenvironment (TME) making GBM hidden from the anti-tumoral immune clearance. Considering this, we aimed to create a panel of prognostic markers from blood and tumor tissue correlating with overall survival (OS) and progression-free survival (PFS). Methods Firstly, we analyzed the inflammatory markers NLR and PLR as the ratio of the absolute neutrophil count and absolute platelet count by the absolute lymphocyte count respectively, collected at different time points in the peripheral blood of 95 patients. Furthermore, in 31 patients of the same cohort, we analyzed the formalin-fixed paraffin embedded samples to further compare the impact of circulating and inflammatory markers within the TME. Results Patients aged < 60 years and with methylated MGMT showed better OS. While, pre-chemotherapy Systemic Inflammatory Index (SII) < 480 was related to a better OS and PFS, we observed that only CD68+macrophage and CD66b+neutrophils expressed in vascular/perivascular area (V) showed a statistically significant prognostic role in median OS and PFS. Conclusions Thus, we underscored a role of SII as predictive value of response to STUPP protocol. Regarding the TME-related markers, we suggested to take into consideration for future studies with new immunotherapy combinations, each component relating to expression of immune infiltrating subsets.

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Neutrophil-to-lymphocyte ratio, factor VIII and antithrombin III: Inflammatory-clotting biomarkers in glioma

Koudriavtseva

Villani

Lorenzano

et al. 2021

Journal of the Neurological Sciences

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The prognostic role of indicators of systemic inflammatory response in patients with glioblastoma

Cited by 16 publications

References 0 publications

Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta‐Analysis

Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta‐Analysis

Immuno markers in newly diagnosed glioblastoma patients underwent Stupp protocol after neurosurgery: a retrospective series

Neutrophil-to-lymphocyte ratio, factor VIII and antithrombin III: Inflammatory-clotting biomarkers in glioma

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