The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases

Abstract

Receptor activator of NF-kB (RANK) pathway regulates bone remodeling and is involved in breast cancer (BC) progression. Genetic polymorphisms affecting RANK-ligand (RANKL) and osteoprotegerin (OPG) have been previously associated with BC risk and bone metastasis (BM)-free survival, respectively. In this study we conducted a retrospective analysis of the association of five missense RANK SNPs with clinical characteristics and outcomes in BC patients with BM. SNP rs34945627 had an allelic frequency of 12.5% in BC patients, compared to 1.2% in the control group (P = 0.005). SNP rs34945627 was not associated with any clinicopathological characteristics, but patients presenting SNP rs34945627 had decreased disease-free survival (DFS) (log-rank P = 0.039, adjusted HR 2.29, 95% CI 1.04–5.08, P = 0.041), and overall survival (OS) (log-rank P = 0.019, adjusted HR 4.32, 95% CI 1.55–12.04, P = 0.005). No differences were observed regarding bone disease-free survival (log-rank P = 0.190, adjusted HR 1.68, 95% CI 0.78–3.66, P = 0.187), time to first skeletal-related event (log-rank P = 0.753, adjusted HR 1.28, 95% CI 1.42–3.84; P = 0.665), or time to bone progression (log-rank P = 0.618, adjusted HR 0.511, 95% CI 0.17–1.51; P = 0.233). Our analysis shows that RANK SNP rs34945627 has a high allelic frequency in patients with BC and BM, and is associated with decreased DFS and OS.

Impact of Orthodontic Forces on Plasma Levels of Markers of Bone Turnover and Inflammation in a Rat Model of Buccal Expansion

“…Possible explanations of the source of increased sRANKL would be from necrotic tissue and resulting proteolysis of transmembrane receptors or upregulation of primary secretion ( Rogers, 2005 ). In this study, we used the sRANKL and OPG as indicators for bone resorption and turnover in line with a previous publication ( Ferreira et al, 2016 ). Further studies are needed to identify the source of sRANKL.…”

First experience of radiofrequency ablation of breast cancer metastases in the vertebra followed by vertebroplasty. A case from practice

“…жінок віком від 13 до 90 років. Ураження кісткової системи зустрічається у 13,6 % хворих на цей тип злоякісних новоутворень [1], а солітарне ураження кісткового апарату -у 41 % з них [2].…”

“…According to the WHO statistics, up to 100 cases of this disease are diagnosed annually per 100 thousand women aged 13 to 90 years. The skeletal system lesions occur in 13.6 % of patients affected by this type of malignancy [1], while solitary lesions of the skeletal system -in 41 % of those ones [2].…”

Development and Validation of Prognostic Nomogram for Elderly Breast Cancer: A Large-Cohort Retrospective Study

“…6,7 Recently, several studies were conducted to study the prognostic factors for BCBM patients. Clinicopathological data, laboratory tests, and genomic data were confirmed as prognostic predictors for BCBM patients, [8][9][10][11][12][13][14][15][16] and several studies aimed to develop prognostic nomograms for BCBM patients. 6,[16][17][18][19] However, elderly BC patients have their own unique characteristics, which suggested that we need to conduct a specific study for this special population.…”