The Prognostic Role of Serum Uric Acid (SUA) in Coronary Artery Disease: PerSUAsive Data Plea for a Large Morbidity-Mortality Trial

Lueder, Thomas G. von; Girerd, Nicolas

doi:10.1159/000444744

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…The incidence of hyperuricemia is increasing gradually worldwide with the improvement in human living standard and dietary structure changes, as well as genetic and environmental factors. [1,2] Epidemiological studies [3–5] at present showed that hyperuricemia, an independent risk factor for the morbidity and mortality of chronic diseases, may be related to obesity, hypertension, diabetes, and metabolic syndrome. Ogura et al [6] studied the relationship between obesity and serum UA and demonstrated a 30% increase in fat as serum UA levels increased 59.5 mol/L.…”

Section: Introductionmentioning

confidence: 99%

Relationship between oxidative stress and inflammation in hyperuricemia

Zhou

Zhao²,

Pu³

et al. 2018

Medicine

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The average age of hyperuricemia patients has gradually decreased, but young patients with primary hyperuricemia often do not exhibit clinical symptoms and have not received sufficient attention. However, a lack of symptoms with primary hyperuricemia does not mean that high serum uric acid (UA) levels cannot lead to pathological effects, such as oxidative stress and inflammation, and the specific damage is still unclear. We aimed to determine the relationship between oxidative stress and inflammation to explore the possible role of pathological damage in asymptomatic young patients with primary hyperuricemia.A total of 333 participants were enrolled in our study: 158 asymptomatic young patients with primary hyperuricemia and 175 healthy persons from a health check-up population. Malondialdehyde (MDA), superoxide dismutase (SOD), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and general biochemical markers were measured.We found no differences in biochemical markers (fasting glucose, TG, TC, LDL-C, HDL-C, SCr, BUN, AST, and ALT) between the patients and healthy persons. Subsequent analyses of oxidative stress and inflammation revealed that the serum levels of MDA, IL-6, and TNF-α in the patients were significantly higher than those in the healthy control group (P < .001), and the SOD activity was significantly lower (P < .001). As the UA levels increased, MDA increased significantly and SOD decreased significantly; likewise, IL-6 and TNF-α increased significantly as the UA level increased. MDA showed a significant positive correlation with IL-6 (r = 0.367, P < .001) and TNF-α (r = 0.319, P < .001), and SOD was negatively correlated with IL-6 (r = −0.241, P < .01) and TNF-α (r = −0.308, P < .001). Multivariable logistic regression analysis showed that UA (OR: 2.379, 95% CI: 1.698–3.286, P < .001; OR: 3.261, 95% CI: 1.729–3.857, P < .001; for IL-6 and TNF-α, respectively) and MDA (OR: 1.836, 95% CI: 1.283–2.517, P < .01; OR: 2.532, 95% CI: 1.693–3.102, P < .001; for IL-6 and TNF-α, respectively) were risk factors for high IL-6 and TNF-α and that SOD (OR: 0.517, 95% CI: 0.428–0.763, P < .01; OR: 0.603, 95% CI: 0.415–0.699, P < .001; for IL-6 and TNF-α, respectively) was a protective factor.In our study, some abnormal pathological effects were found in asymptomatic young patients with hyperuricemia, suggesting that in young hyperuricemia patients, oxidative stress, inflammation and the inflammatory response may be related to the oxidative stress induced by UA. Therefore, we should pay more attention to the pathological damage caused by these alterations.

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Section: Introductionmentioning

confidence: 99%

Relationship between oxidative stress and inflammation in hyperuricemia

Zhou

Zhao²,

Pu³

et al. 2018

Medicine

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“…The purine catabolic metabolic process in the human body produces uric acid as a byproduct. Due to changes in consumption patterns of purine-rich foods, genetic, and environmental variables, the prevalence of hyperuricemia is gradually increasing over the world (Chatzipavlou et al, 2014;von Lueder & Girerd, 2016) Hyperuricemia is a metabolic illness that is linked to age, sex, lifestyle behaviors, and genetic factors. Hyperuricemia has been linked to high blood pressure, diabetes, dyslipidemia, kidney failure, obesity, and liver disease.…”

Section: Introductionmentioning

confidence: 99%

Beetroot Powder (Beta vulgaris L.) Decrease Oxidative Stress by Reducing of Malondialdehyde (MDA) Levels in Hyperuricemia

Wulandari

Dirgahayu

Wiboworini

2021

JICP

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Introduction: Hyperuricemia is a metabolic disease associated with lifestyle habits, age, sex, and inherited factors. High uric acid levels in a hyperuricemia state cause oxidative stress that can lead to increased malondialdehyde (MDA) levels. Beetroot powder has the potential as a functional food rich in antioxidants that can reduce MDA levels. This study aims to determine the beetroot powder effect on MDA level reduction in hyperuricemia rat models. Methods: This research was an experimental study with fifteen hyperuricemia rats were divided into three groups by randomized pre-post control group design. They were divided into three groups: P1 were healthy rats + standard feed (comfeed), P2 were hyperuricemia rat models + standard feed (comfeed) and P3 were hyperuricemia rat models + beetroot powder 3,12 g/kg/bw for 14 days. The MDA level examinations were conducted on day 0 and day 14. Results: After 14 days of treatment, the P3 group has a significant decrease in MDA levels compared to day 0 (p = 0.042). Groups P1 and P2 have a significant increase in MDA levels (p = 0.043). MDA levels between groups were significantly different (p = 0.002) on day 14. Conclusion: Giving beetroot powder for 14 days with dose 3,12 g/kg/bw for 14 days significantly reduced MDA levels in hyperuricemia.

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The Prognostic Role of Serum Uric Acid (SUA) in Coronary Artery Disease: PerSUAsive Data Plea for a Large Morbidity-Mortality Trial

Cited by 2 publications

References 15 publications

Relationship between oxidative stress and inflammation in hyperuricemia

Relationship between oxidative stress and inflammation in hyperuricemia

Beetroot Powder (Beta vulgaris L.) Decrease Oxidative Stress by Reducing of Malondialdehyde (MDA) Levels in Hyperuricemia

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