The Prognostic Significance of Multiple Pelvic Node Metastases in Cervical Cancer Patients Treated With Radical Hysterectomy Plus Adjuvant Chemoradiotherapy

Abstract

The presence of multiple pelvic node metastases was not an independent predictor of shorter PFS in the CCRT group.

The Prognosis and Risk Stratification Based on Pelvic Lymph Node Characteristics in Patients With Locally Advanced Cervical Squamous Cell Carcinoma Treated With Concurrent Chemoradiotherapy

“…Other studies 14,15,22 have reported that the number of metastatic LNs is an independent predictive factor for overall survival. Okazawa et al 15 investigated the prognostic significance of multiple PLN metastases in cervical cancer patients who were treated with radical hysterectomy plus adjuvant chemoradiotherapy.…”

“…Recent studies have reported that the number of LN metastases is an independent risk factor for worse survival in patients with early stage cervical cancer. 14,15 Other studies have found the relationship between the size of the positive LNs and the prognosis of patients with cervical cancer. 16,17 However, in the era of modern therapy, the influence of LN characteristics on the prognosis of cervical cancer has not yet been systematically evaluated.…”

Incorporation of the number of positive lymph nodes leads to better prognostic discrimination of node-positive early stage cervical cancer

“…However, it is unknown whether postoperative CCRT could influence the prognostic value of the number of positive LNs. Okazawa et al studied 119 patients with FIGO IB1-IIB cervical cancer and found that the number of positive LNs (> 2 vs. 1–2 positive LNs) only had clinical value in patients who received postoperative RT ( n = 67), but not in adjuvant CCRT ( n = 70) [19]. We were unable to extract information from the study by Okazawa et al on how treatment decisions were made, such as the combination of postoperative RT with CCRT [19].…”

“…Okazawa et al studied 119 patients with FIGO IB1-IIB cervical cancer and found that the number of positive LNs (> 2 vs. 1–2 positive LNs) only had clinical value in patients who received postoperative RT ( n = 67), but not in adjuvant CCRT ( n = 70) [19]. We were unable to extract information from the study by Okazawa et al on how treatment decisions were made, such as the combination of postoperative RT with CCRT [19]. Previous studies indicated that adjuvant CCRT with cisplatin is superior to RT alone in terms of both OS and progression-free survival in node-positive cervical cancer [13, 20].…”

Impact of histological subtype on survival of patients with surgically-treated stage IA2–IIB cervical cancer: Adenocarcinoma versus squamous cell carcinoma

“…Of a total of 520 patients, 295 were treated within the context of previous clinical studies [20][21][22][23].…”