The prognostic significance of non-lymphoid immune cells of the tumor microenvironment, including neutrophils, eosinophils, and mast cells in breast carcinomas

Okçu, Oğuzhan; Öztürk, Çiğdem; Şen, Bayram; Ayazoğlu, Safa; Güvendi, Gülname Fındık; Öztürk, Seda Duman; Aşkan, Gökçe; Bedir, Recep

doi:10.1016/j.anndiagpath.2023.152151

Cited by 4 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[77] The presence and characteristics of tumor-infiltrating neutrophils or TANs within breast cancer tissues have been associated with patient prognosis. [78] High levels of neutrophil infiltration may be correlated with poorer outcomes in certain breast cancer subtypes, as they can contribute to an immunosuppressive and pro-tumorigenic microenvironment. [79] Neutrophil presence and activity can serve as predictive biomarkers for therapeutic responses in breast cancer.…”

Section: Clinical Implications Of Neutrophils In Breast Cancermentioning

confidence: 99%

Exploring neutrophil functionality in breast cancer progression: A review

Obeagu,

Obeagu

2024

Medicine

View full text Add to dashboard Cite

Breast cancer remains a pressing global health concern, with a myriad of intricate factors contributing to its development, progression, and heterogeneity. Among these multifaceted elements, the role of immune cells within the tumor microenvironment is gaining increasing attention. In this context, neutrophils, traditionally regarded as the first responders to infections, are emerging as noteworthy participants in the complex landscape of breast cancer. This paper seeks to unravel the intricate and multifaceted role of neutrophils in breast cancer. Neutrophils, classically known for their phagocytic and pro-inflammatory functions, are now recognized for their involvement in promoting or restraining tumor growth. While their presence within the tumor microenvironment may exert antitumor effects through immune surveillance and cytotoxic activities, these innate immune cells can also facilitate tumor progression by fostering an immunosuppressive milieu, promoting angiogenesis, and aiding metastatic dissemination. The intricacies of neutrophil-tumor cell interactions, signaling pathways, and mechanisms governing their recruitment to the tumor site are explored in detail. Challenges and gaps in current knowledge are acknowledged, and future directions for research are outlined. This review underscores the dynamic and context-dependent role of neutrophils in breast cancer and emphasizes the significance of unraveling their multifaceted contributions. As we delve into the complexities of the immune landscape in breast cancer, a deeper understanding of the warriors within, the neutrophils, presents exciting prospects for the development of novel therapeutic strategies and a more comprehensive approach to breast cancer management.

show abstract

Section: Clinical Implications Of Neutrophils In Breast Cancermentioning

confidence: 99%