2019
DOI: 10.1007/s00262-019-02407-8
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The prognostic significance of peritumoral tertiary lymphoid structures in breast cancer

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Cited by 97 publications
(78 citation statements)
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“…In a study conducted by Liu and colleagues, TLSs were significantly associated with favorable DFS in patients with HER2+ breast cancer, independent of TIL status (76). In contrast, a recent analysis of all breast cancer subtypes reported that the presence and density of peritumoral TLSs were not independently associated with DFS and OS (80). Interestingly, TLSs have been demonstrated to be significant predictors of pCR in TNBC patients treated with NAC (78).…”
Section: Tumor-associated Tertiary Lymphoid Structures (Tls)mentioning
confidence: 96%
“…In a study conducted by Liu and colleagues, TLSs were significantly associated with favorable DFS in patients with HER2+ breast cancer, independent of TIL status (76). In contrast, a recent analysis of all breast cancer subtypes reported that the presence and density of peritumoral TLSs were not independently associated with DFS and OS (80). Interestingly, TLSs have been demonstrated to be significant predictors of pCR in TNBC patients treated with NAC (78).…”
Section: Tumor-associated Tertiary Lymphoid Structures (Tls)mentioning
confidence: 96%
“…Further studies found that TLSs are associated with increased lymphocyte infiltration into tumors with extended DFS in breast cancer and colorectal cancer ( 191 ). However, the role of TLSs in predicting the prognosis is still under debate because another study of breast cancer showed that patients with abundant TLSs exhibited worse DFS and OS than those lacking TLSs ( 192 ). The cellular component in TLSs has also aroused the interest of scientists.…”
Section: Spatial Architecture Of the Time In Clinical Applicationmentioning
confidence: 99%
“…A favorable impact of TLS density on overall survival (OS) and disease-free survival (DFS) of patients has been observed. 62,63,[66][67][68][69][70][71] An important component of TLS are HEV. These are specialized postcapillary venules found in lymphoid tissues that support high levels of lymphocyte extravasation from the blood.…”
Section: Nature Of Immune Cells In Tertiary Lymph Structures In Breastmentioning
confidence: 99%