The Prognostic Significance of Tumor Response During Radiotherapy in Cervical Carcinoma

RAR-Beta Expression Is Associated with Early Volumetric Changes to Radiation Therapy in Cervical Cancer

“…In the present study, the status of early volumetric changes assessed by MRI correlated with progression-free and overall survival. These results are consistent with earlier studies showing that early regression during or immediately after RT is a predictor of outcome of cervical cancer [4][5][6][7] .…”

“…Marcial et al [4] and Grossman et al [5] reported a correlation between early tumor regression and the probability of permanent control. Hardt et al [6] and Jacobs et al [7] concluded that patients with no residual tumor 1 month after treatment had a marked survival advantage.…”

Metastatic Lymph-node Clearance from Head and Neck Epidermoid Carcinomas Following Radiotherapy

“…Radioresponsiveness, that is, patterns of tumor clearance following radiotherapy (RT), is used as a major criterion in assessing the impact of RT on a tumor and in predicting radiocurability (1)(2)(3). According to this criterion, tumors that are oncologically sterilized but respond slowly or persist long are regarded as radioresistant or radioincurable.…”

Comparison of tumor regression rate of uterine cervical squamous cell carcinoma during external beam and intracavitary radiotherapy

“…For RT of cervical cancer, major predictable prognostic factors include clinical stage, tumor size, and tumor geometry (exophytic or endophytic). 1,2 In addition, the tumor radioresponse, which comprises tumor cell radiosensitivity but cannot be predicted before RT, is also prognostic of local disease control 3,4 and may be the most powerful among the factors. 5 In clinical practice, residual tumor mass assessed by pelvic examination 6,7 and more recently by objective magnetic resonance (MR) imaging 8,9 is often used as a prognostic factor that incorporates all these factors.…”