The prognostic value of antibodies to gp210 among patients with primary biliary cholangitis in Northeast China

Correlation between individual autoantibodies and clinical features in primary biliary cholangitis: results of a retrospective longitudinal study

“…Our longitudinal retrospective study goes in line with the current notion that PBC is more frequently diagnosed in middle-aged females [29], with an almost 9 : 1 female to male ratio, and with AMA positivity in up to 90% of the patients [13]. Also, our epidemiological results do not differ from those recently published by Helena Cortez-Pinto et al in the largest Portuguese nationwide PBC published study, probably reflecting the same genetic and environmental background [30].…”

“…This is consistent with other studies who have checked that, as a biomarker, anti-gp210 antibody was associated with a more severe cholestatic manifestation and a worse long-term prognosis 40,41 . Furthermore, in a recent study, positivity for anti-gp210 antibody was independently associated with a higher risk of liverrelated death or transplantation 13 . Nakamura et al hypothesized that the presence of anti-gp210 is associated with liver failure type progression 16,43 and that it's serial quantitation is useful for monitoring the effect of UDCA and for the early identification of patients at high risk for end-stage hepatic failure 39 .…”

“…Thus far, the role of the immunological profile in PBC patients and outcome has not been extensively studied, with the reported series commonly small-sized. To the best of our knowledge, only eight studies have addressed this issue, with the majority of them concerning populations in Asia and with a retrospective character [12][13][14][38][39][40][41][42] (Table 5). The proportion of patients with positive anti-gp210 and anti-Sp100 antibodies in our study is similar to that found in other studies (approximately 20%) [9,14,42,43], even though probably underestimated, as not all patients underwent the complete immunological liver profile.…”

“…Granito et al showed that the concomitant positivity for both anti-Sp100 and anti-gp210 antibodies showed a 100% positive predictive value for PBC, irrespective of the AMA status [10]. The presence of these autoantibodies seems to be associated with an unfavorable course of the disease, regardless of the bilirubin value (which has, per se, an impact on prognosis) [7,[11][12][13], as well as the presence of anticentromere antibodies that have been associated to a phenotype of greater expression of portal hypertension [14][15][16]. Anti-hexokinase 1 and antikelch-like 12 antibodies, besides being very specific and prevalent [17], seem to be related to shorter survival and reduced time to liver decompensation and transplantation [18].…”

The Albumin-Bilirubin Score as a Predictor of Liver-Related Mortality in Primary Biliary Cholangitis with Compensated Cirrhosis

“…It is well known that serum TBIL and ALB are part of a group of tests widely known as liver function tests. We demonstrated that higher TBIL and lower ALB levels were independently associated with an increase in liver-related mortality or LT. Our findings share many similarities with previous findings [4, 22–26]. In their study, multivariate regression analysis showed that serum ALB and TBIL were independent prognostic factors for adverse outcomes.…”