The Prognostic Value of Decreased KLF4 in Digestive System Cancers: A Meta-Analysis from 17 Studies

Hu, Jianpei; Li, Huipu; Wu, Chun-Yu; Zhao, Xingyu; Liu, Chaodong

doi:10.1155/2017/3064246

Cited by 8 publications

(6 citation statements)

References 41 publications

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“…A meta-analysis of 17 studies on malignant tumours of the digestive system showed that a decrease in KLF4 was associated with poorer survival outcomes [ 47 ]. The underlying mechanism of KLF4 downregulation in cancer remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of KLF4 in solid tumours: an updated meta-analysis

Luo

Zhang²,

Meng

et al. 2022

BMC Cancer

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Background Kruppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor predominantly expressed in terminally differentiated epithelial tissues. Many studies have shown that KLF4 has various mechanisms in different tumours; however, the prognostic role of KLF4 remains unclear. Methods and results We searched the relevant literature that evaluated the prognostic value of KLF4 in different cancers, and the original survival data were obtained from the text, tables or Kaplan–Meier curves for both comparative groups. Thirty studies were included in this meta-analysis, and a total of 10 malignant tumours were involved. The expression of KLF4 was not associated with the prognosis for overall survival (hazard ratio(HR)0.86, 95% confidence interval (CI): 0.65–1.13, P = 0.28), disease-free survival/recurrence-free survival/metastasis-free survival (HR 0.87, 95% CI: 0.52–1.44, P = 0.58) or disease-specific survival (HR 1.13, 95% CI: 0.44–2.87, P = 0.8). Conclusion This study showed that the expression of KLF4 was not related to the prognosis of the tumours that were included in the study.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of KLF4 in solid tumours: an updated meta-analysis

Luo

Zhang²,

Meng

et al. 2022

BMC Cancer

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“…Tumors of the digestive system are among the most common malignancies worldwide ( 44 ). Indeed, HCC, stomach cancer and CRC are the leading causes of digestive system cancer-related deaths, placing a heavy burden on societies worldwide ( 45 ). HCC alone is the fifth most common cancer worldwide.…”

Section: Mapk/erk Signaling Pathway-related Circrna Molecules and Digestive System Tumorsmentioning

confidence: 99%

Circular RNA regulates the onset and progression of cancer through the mitogen‑activated protein kinase signaling pathway (Review)

Lai

Wang

et al. 2021

Oncol Lett

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The rapid increase in cancer morbidity and mortality worldwide is a major challenge for public health providers. Therefore, there is an urgent need to explore the molecular mechanism of tumorigenesis and identify potential diagnostic biomarkers and therapeutic methods. Circular RNA (circRNA) is characterized by a stable structure and tissue-specific expression; these features are useful in medical research and clinical applications. In recent years, with the development of high-throughput sequencing technology, the potential use of circRNA in cancer prognosis and treatment has been extensively explored. Abnormal circRNA expression interferes with specific signaling pathways such as the MAPK pathway; this phenomenon may provide potential diagnostic biomarkers and new therapeutic targets. The present article discusses the research progress on the regulatory roles of MAPK/ERK pathway-related circRNA molecules in the development and progression of different types of tumors. This review may provide insight into the development of circRNA-based cancer management strategies.

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“…MMP14 expression was associated with advanced tumor stage in colon cancer (21). Loss of KLF4 expression is correlated with a worse outcome (22). CD166 expression indicate advanced T category and N-positive status in colorectal cancer (23).…”

Section: Introductionmentioning

confidence: 98%

A prospective cohort study of TIMP1 as prognostic biomarker in gastric and colon cancer

et al. 2022

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Background: Tissue inhibitor metalloproteinase 1 (TIMP1) inhibits proteins which has proteolytic activity, but in cancer it contributes for tumoral invasion and metastization. The authors investigated the expression of TIMP1 in different digestive cancer types. The aim of this study was to test TIMP1 as a serum marker since in clinical practice there is a lack of biomarkers to monitor the response to treatments or to detect early relapses.Methods: It was performed a prospective study with recent diagnosed patients with gastrointestinal cancers. Patients with esophageal, gastric, colon, rectal, hepatocarcinoma, and cholangiocarcinoma at any stage, that did not perform any type of treatment, were included. Enzyme-linked immunosorbent assays and chemiluminescence were used to quantify levels of TIMP1. The differences of the Kaplan-Meier survival curves were tested for statistical significance with the log rank test, and the 95% confidence intervals were calculated. Multivariate analysis was done using the COX proportional hazard model and a forward stepwise method. Statistical analyses were done using the IBM SPSS Statistics version 26.0. P value inferior to 0.05 was considered significant.Results: A total of 190 patients were recruited: 54.7% males, median age of 68 years old, 57.9% with colorectal cancer followed by esophagogastric disease with 22.6%. TIMP1 level were increased in 29.5%. In colon cancer, patients with higher levels of TIMP1 are associated with worse progression free survival (PFS) (P=0.007) and overall survival (OS) (P=0.036). No relationship was seen with Rat sarcoma virus (RAS), B-raf (BRAF) and Microsatellite instability status (MSI). In gastric cancer, patients with higher levels of TIMP1 are associated with worse OS (P=0.020), with no difference in PFS.Conclusions: Higher TIMP1 levels in gastric and colon cancer patients are associated with worse prognosis. Further studies are needed: higher number of patients and sequential measurements of TIMP1 during patient treatments.

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The Prognostic Value of Decreased KLF4 in Digestive System Cancers: A Meta-Analysis from 17 Studies

Cited by 8 publications

References 41 publications

Prognostic significance of KLF4 in solid tumours: an updated meta-analysis

Prognostic significance of KLF4 in solid tumours: an updated meta-analysis

Circular RNA regulates the onset and progression of cancer through the mitogen‑activated protein kinase signaling pathway (Review)

A prospective cohort study of TIMP1 as prognostic biomarker in gastric and colon cancer

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