The Prognostic Value of Left Bundle Branch Block and Biochemical Parameters in Alcoholic Dilated Cardiomyopathy

Colorectal cancer is a malignant disease with high morbidity and mortality. Ki-67 is a marker of cell proliferation associated with a low survival in colorectal cancer patients. Its expression is increased in patients with Dukes C or D colorectal cancer versus those in stage A or B. The purpose of the study is to evaluate the immunohistochemical expression of the Ki-67 marker in colorectal adenocarcinomas. The study was performed on a group of 28 patients diagnosed with rectal cancer. We made the histopathological and immunohistochemical evaluation of patients in the study group. The evaluation was performed on the sections stained with hematoxylin-eosin, and for mucinous forms, on sections stained with alcian blue. The topography of the Ki-67 reaction is strictly nuclear, evident in areas with intense proliferative activity. In cases with a strong positive response to Ki-67, the prognosis is worse, with invasion of the perirectal tissues and metastases. The lack of Ki-67 expression in nearby neoplastic tissues suggests that cancerous tissue proliferates in a pathway that it is not correlated with adjacent tissues. The Ki-67 could be useful in the prognosis of patients with colorectal cancer.

Section: Resultsmentioning

confidence: 93%

Anatomical and Immunohistochemical Evaluation of Colorectal Cancer

Hînganu¹,

Stan²,

Ciupilan³

et al. 2019

“…Assessing the long term arrhythmic risk in patients with acute myocardial infarction and left bundle branch block, we observed a higher risk of ventricular premature beats in patients with left bundle branch block (18 vs. 5, p = 0.003), both on the initial hospitalization and control assessment, with statistically significant differences compared with patients without left bundle branch block ( fig.3). The combination of the left bundle branch block in patients with heart failure leads to a reserved prognosis, the prolonged duration of the QRS complex being considered an independent negative predictor [8][9][10][11][12]. Most patients with left ventricular systolic dysfunction and prolonged QRS complex duration have also left bundle branch block [13][14][15].…”

Section: Resultsmentioning

confidence: 99%

The Significance of New Left Bundle Branch Block Complicating Acute Myocardial Infarction

Georgescu¹,

Anghel²

2018

The aim of our study was to evaluate the impact of new LBBB on left ventricular systolic function and arrhythmic risk in patients with acute myocardial infarction and unicoronarian lesion. We prospectively studied the patients with acute myocardial infarction with and without LBBB and unicoronarian lesion after a mean of 16.51 � 2.41 months from the onset of acute coronary event. We observed a higher risk of ventricular premature beats and left ventricular systolic disfunction in patients with left bundle branch block. Also, the presence of left bundle branch block (F = 3.64; p [ 0.005; partly h2= 0.33) and the duration of the QRS complex (F = 4.17; p [ 0.005; partly h2= 0.36) was statistically significantly correlated with the value of left ventricular ejection fraction. Almost a double number of patients with left bundle branch block had an ejection fraction below 30%, despite an early revascularization. Patients with acute myocardial infarction and left bundle branch block represent a relatively small group but with an increased risk of malignant ventricular arrhythmias and left ventricular systolic dysfunction, and they should therefore benefit from a promptly and appropriately treatment in order to improve long term outcome.

“…CABG proved to be effective in reducing the value of different parameters reflecting cardiac ischemia, and also in ameliorating the cardiovascular risk scores [14,15].…”

Section: Discussionmentioning

confidence: 99%

QRISK2 Score in CABG Patients Correlated with Risk Factors

Bazyani¹,

Namat²,

Felea³

et al. 2019

Self Cite

Guidelines for primary prevention suggested using any risk score, among those QRISK2, identifying the high-risk populations. The purpose of this study was to determine whether the QRISK2 Score would register changes in patients with coronary artery disease demanding acute or postponed CABG intervention. The QRISK2 Score was performed the day of admission after the clinical examination and blood test results, and immediately after CABG surgery (in the first week post-CABG, in an interval of 24 hours to 7 days) having another blood test evaluation. The 120 patients admitted in the Clinic of Cardiovascular Surgery of the Institute of Cardiovascular Disease met the inclusion criteria: CABG patients (less than 1 week), aged 40-85 years old, BMI ] 25 kg/m�, and mixed dyslipidemia. In both phases, for every patient, it was performed a clinical examination, a set of hematological, biochemical, lipid, coagulation and inflammatory profile, and ECG and echocardiography. Our research on hospitalized patients undergoing CABG, by comparing the Phase I and Phase III results, revealed that the median 10-year QRISK2 cardiovascular risk score was approximately 47.88 % lower (p=0.000) in the first week after cardiac surgery. QRISK2 score gives a more appropriate risk estimation based on the social component, thus identifying high risk patients associating social deprivation. Comparative to Framingham risk score, QRISK2 score, by including additional variables, proves the efficacy of lifestyle changes and management decisions, and sustaines the treatment directed towards modifying variables or risk factors.