The prognostic value of serum and immunohistochemical tumour markers in advanced gastric cancer

Webb, Amy; Scott-Mackie, P.; Cunningham, David; Norman, A.; Andreyev, Jervoise; O’Brien, Michael; Bensted, J.

doi:10.1016/0959-8049(95)00504-8

Cited by 63 publications

(71 citation statements)

References 31 publications

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“…One previous study, including only patients with advanced disease, showed hCG␤ to correlate with unfavourable prognosis in gastric cancer. 13 Overall our results corroborate previous findings. Tumour stage was observed to correlate with elevated marker levels, except with CA 19-9, with which the association between marker positivity and stage was only of borderline significance.…”

Section: Discussionsupporting

confidence: 92%

“…13 Accordingly, including only the advanced disease in analysis in our study (stage III and IV), we confirmed the previous findings. HCG␤, CA 72-4 as well as tumour histology and stage emerged as independent prognostic factors.…”

Section: Discussionsupporting

confidence: 91%

“…Several studies have demonstrated CEA to have independent prognostic value, 5,17-21 but in other studies no significant correlation with survival has been found. 6,7,13,22,23 CA 19-9 has also been shown to be an independent prognostic factor in some 5,19,22 but not in other studies. 6,7,13,21,23 Furthermore, CA 72-4 has been reported to be a stronger prognostic factor than CEA and CA 19-9 in gastric cancer 6 but in other studies CA 72-4 has lacked independent prognostic value.…”

Section: Discussionmentioning

confidence: 78%

“…6,7,13,22,23 CA 19-9 has also been shown to be an independent prognostic factor in some 5,19,22 but not in other studies. 6,7,13,21,23 Furthermore, CA 72-4 has been reported to be a stronger prognostic factor than CEA and CA 19-9 in gastric cancer 6 but in other studies CA 72-4 has lacked independent prognostic value. 5,7 Of the less-established tumour markers in gastric cancer, we have previously shown CA 242 to be an independent prognostic factor in colorectal cancer, 9 but to the best of our knowledge, the association between CA 242 and survival has not been reported in gastric cancer.…”

Section: Discussionmentioning

confidence: 78%

“…12 In a study of advanced gastric cancer, hCG␤ was suggested to be an independent prognostic factor of poor outcome. 13 The aim of our study was to evaluate and compare the prognostic significance of serum tumour markers CEA, CA 19-9, CA 72-4, CA 242, and hCG␤ in patients with gastric cancer.…”

mentioning

confidence: 99%

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Preoperative hCGβ and CA 72‐4 are prognostic factors in gastric cancer

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

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Clinical significance of circulating tumor cells in blood from patients with gastric cancer

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Circulating tumor cells (CTC) have been focused on as a target for detecting occult tumors, predicting therapeutic responses and prognoses, and monitoring postoperative recurrence in the clinical management of patients with various malignancies, including gastric cancer. Recent advances in molecular diagnostic tools have contributed to high sensitivity and specificity for the detection of CTC. A conspicuous disparity exists in the incidence of CTC among studies. However, a close relationship has been reported between positivity for CTC and well‐known prognostic clinicopathological factors including depth of tumor invasion, lymph node metastasis, stage, and lymphatic and venous invasion in patients with gastric cancer. According to most studies published on the clinical impact of CTC, the presence of CTC negatively affects the prognosis of patients with gastric cancer. Moreover, the study of CTC based on a meta‐analysis demonstrated their importance as a poor prognostic indicator. In clinical management, pre‐ and post‐therapeutic monitoring of CTC using liquid biopsy may be useful for early detection of subclinical patients or disease recurrence, prediction of tumor progression, and administrative control of adjuvant chemotherapy. Although their functional properties remain unclear, molecular profiling of CTC may contribute to the development of personalized treatment that effectively inhibits tumor progression in patients with advanced gastric cancer. We herein review the clinical significance of CTC as a promising blood marker and therapeutic target in patients with gastric cancer.

show abstract

The prognostic value of serum and immunohistochemical tumour markers in advanced gastric cancer

Cited by 63 publications

References 31 publications

Preoperative hCGβ and CA 72‐4 are prognostic factors in gastric cancer

Preoperative hCGβ and CA 72‐4 are prognostic factors in gastric cancer

Serum CA 125 level as a predictor of peritoneal dissemination in patients with gastric carcinoma

Clinical significance of circulating tumor cells in blood from patients with gastric cancer

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