The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Deng, Qiu Hong; Jia, Gang; Zhao, Hua; Chen, Zheng Li; Chen, Xiao Ling; Liu, Guang Mang; Wang, Kang Ning

doi:10.1186/s40104-016-0087-7

Cited by 12 publications

(19 citation statements)

References 34 publications

(43 reference statements)

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“…Increased villus height and villus height-to-crypt depth ratio are associated with digestion and absorption of nutritious substances that are related to growth performance. Growth factors, such as the glucagon-like peptide 1 (GLP-1), GLP-2, epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-1), and IGF-1 receptor (IGF-1R) proteins, are also able to increase the proliferation, differentiation, and apoptosis of intestinal epithelial cells ( Deng et al., 2016 ; Shawe-Taylor et al., 2017 ; Wang et al., 2020 ). For example, oral administration of 10-mL GOS in solution (1 g/kg BW) to suckling piglets upregulated the mRNA expression of IGF-1, IGF-1R, EGF , GLP-1 , and GLP-2 .…”

Section: Prebiotics and Intestinal Health Of Monogastric Animalsmentioning

confidence: 99%

Opportunities of prebiotics for the intestinal health of monogastric animals

Azad

Gao

et al. 2020

Animal Nutrition

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The goal of prebiotic applications from different sources is to improve the gut ecosystem where the host and microbiota can benefit from prebiotics. It has already been recognized that prebiotics have potential roles in the gut ecosystem because gut microbiota ferment complex dietary macronutrients and carry out a broad range of functions in the host body, such as the production of nutrients and vitamins, protection against pathogens, and maintenance of immune system balance. The gut ecosystem is very crucial and can be affected by numerous factors consisting of dietary constituents and commensal bacteria. This review focuses on recent scientific evidence, confirming a beneficial effect of prebiotics on animal health, particularly in terms of protection against pathogenic bacteria and increasing the number of beneficial bacteria that may improve epithelial cell barrier functions. It has also been reviewed that modification of the gut ecosystem through the utilization of prebiotics significantly affects the intestinal health of animals. However, the identification and characterization of novel potential prebiotics remain a topical issue and elucidation of the metagenomics relationship between gut microbiota alteration and prebiotic substances is necessary for future prebiotic studies.

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Section: Prebiotics and Intestinal Health Of Monogastric Animalsmentioning

confidence: 99%

Opportunities of prebiotics for the intestinal health of monogastric animals

Azad

Gao

et al. 2020

Animal Nutrition

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“…IAP is strongly inhibited after early weaning in pigs and this is considered as a major factor in post-weaning disorders and enhanced piglet sensitivity to enteric infections [49]. The hormone glucagon-like peptide 2 (GLP-2), known for its intestine-trophic properties has been recently shown to stimulate duodenal and jejunal IAP in weaned pigs injected with exogenous (human) GLP-2 [50]. This was associated with the maturation of intestinal epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Microbiota-host interplay at the gut epithelial level, health and nutrition

Lallès

2016

J Animal Sci Biotechnol

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Growing evidence suggests the implication of the gut microbiota in various facets of health and disease. In this review, the focus is put on microbiota-host molecular cross-talk at the gut epithelial level with special emphasis on two defense systems: intestinal alkaline phosphatase (IAP) and inducible heat shock proteins (iHSPs). Both IAP and iHSPs are induced by various microbial structural components (e.g. lipopolysaccharide, flagellin, CpG DNA motifs), metabolites (e.g. n-butyrate) or secreted signal molecules (e.g., toxins, various peptides, polyphosphate). IAP is produced in the small intestine and secreted into the lumen and in the interior milieu. It detoxifies microbial components by dephosphorylation and, therefore, down-regulates microbe-induced inflammation mainly by inhibiting NF-κB pro-inflammatory pathway in enterocytes. IAP gene expression and enzyme activity are influenced by the gut microbiota. Conversely, IAP controls gut microbiota composition both directly, and indirectly though the detoxification of pro-inflammatory free luminal adenosine triphosphate and inflammation inhibition. Inducible HSPs are expressed by gut epithelial cells in proportion to the microbial load along the gastro-intestinal tract. They are also induced by various microbial components, metabolites and secreted molecules. Whether iHSPs contribute to shape the gut microbiota is presently unknown. Both systems display strong anti-inflammatory and anti-oxidant properties that are protective to the gut and the host. Importantly, epithelial gene expressions and protein concentrations of IAP and iHSPs can be stimulated by probiotics, prebiotics and a large variety of dietary components, including macronutrients (protein and amino acids, especially L-glutamine, fat, fiber), and specific minerals (e.g. calcium) and vitamins (e.g. vitamins K1 and K2). Some food components (e.g. lectins, soybean proteins, various polyphenols) may inhibit or disturb these systems. The general cellular and molecular mechanisms involved in the microbiota-host epithelial crosstalk and subsequent gut protection through IAP and iHSPs are reviewed along with their nutritional modulation. Special emphasis is also given to the pig, an economically important species and valuable biomedical model.

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“…weaned piglets, GLP-2 supplementation improved their growth, and promoted the development of intestinal morphology and the activity of digestive and absorptive enzymes[4,8,19]. Unexpectedly, we did not observe any positive effects of GLP-2 supplementation on fecal bacterial communities and cytokine responses, although it provided for better growth.…”

mentioning

confidence: 48%

Effects of Glucagon-Like Peptide-2-Expressing Saccharomyces cerevisiae Not Different from Empty Vector

Zhong

Liang

Cao

et al. 2019

Journal of Microbiology and Biotechnology

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Saccharomyces cerevisiae (S. cerevisiae) and glucagon-like peptide-2 (GLP-2) have been employed to improve the intestinal development of weaned animals. The goal of this study was to determine whether either exogenous S. cerevisiae or GLP-2 elicits major effects on fecal microbiotas and cytokine responses in weaned piglets. Ninety-six piglets weaned at 26 days were assigned to one of four groups: 1) Basal diet (Control), 2) empty vector-harboring S. cerevisiae (EV-SC), 3) GLP-2-expressing S. cerevisiae (GLP2-SC), and 4) recombinant human GLP-2 (rh-GLP2). At the start of the post-weaning period (day 0), and at day 28, fecal samples were collected to assess the bacterial communities via sequencing the V1-V2 region of the 16S-rRNA gene, and piglets' blood was also sampled to measure cytokine responses (i.e., IL-1β, TNF-α, and IFN-γ). This study revealed that, on the one hand, although S. cerevisiae supplementation did not significantly alter the growth of weaned piglets, it induced increases in the relative abundances of two core genera (Ruminococcaceae_norank and Erysipelotrichaceae_norank) and decreases in the relative abundances of two other core genera (Lachnospiraceae_norank and Clostridiale_norank) and cytokine levels (IL-1β and TNF-α) (p < 0.05, Control vs EV-SC; p < 0.05, rh-GLP2 vs GLP2-SC). On the other hand, GLP-2 supplementation had no significant influence on fecal bacterial communities and cytokine levels, but it produced better body weight and average daily gain (p < 0.05, Control vs EV-SC; p < 0.05, rh-GLP2 vs GLP2-SC). Therefore, altered fecal microbiotas and cytokine response effects in weaned piglets were due to S. cerevisiae rather than GLP-2.

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The prolonged effect of glucagon-like peptide 2 pretreatment on growth performance and intestinal development of weaned piglets

Cited by 12 publications

References 34 publications

Opportunities of prebiotics for the intestinal health of monogastric animals

Opportunities of prebiotics for the intestinal health of monogastric animals

Microbiota-host interplay at the gut epithelial level, health and nutrition

Effects of Glucagon-Like Peptide-2-Expressing Saccharomyces cerevisiae Not Different from Empty Vector

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