The promise of music therapy for Alzheimer's disease: A review

Matziorinis, Anna Maria; Koelsch, Stefan

doi:10.1111/nyas.14864

Cited by 62 publications

(48 citation statements)

References 86 publications

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“…Music therapy is an inexpensive and non-invasive therapy, the main advantage of which is the absence of the side-effects of pharmacological therapy [ 156 ]. This type of treatment has been shown to be effective in a variety of neurodegenerative pathologies such as AD, Huntington’s disease, and PD [ 157 ]. In relation to the latter, music therapy has been shown to be an effective intervention in the therapeutic approach to this pathology by improving the motor function, balance, freezing of gait, gait speed, and mental health of affected patients [ 158 ].…”

Section: Resultsmentioning

confidence: 99%

Current Treatments and New, Tentative Therapies for Parkinson’s Disease

Pardo-Moreno¹,

García‐Morales

Suleiman‐Martos

et al. 2023

Pharmaceutics

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Parkinson’s disease (PD) is a neurodegenerative pathology, the origin of which is associated with the death of neuronal cells involved in the production of dopamine. The prevalence of PD has increased exponentially. The aim of this review was to describe the novel treatments for PD that are currently under investigation and study and the possible therapeutic targets. The pathophysiology of this disease is based on the formation of alpha-synuclein folds that generate Lewy bodies, which are cytotoxic and reduce dopamine levels. Most pharmacological treatments for PD target alpha-synuclein to reduce the symptoms. These include treatments aimed at reducing the accumulation of alpha-synuclein (epigallocatechin), reducing its clearance via immunotherapy, inhibiting LRRK2, and upregulating cerebrosidase (ambroxol). Parkinson’s disease continues to be a pathology of unknown origin that generates a significant social cost for the patients who suffer from it. Although there is still no definitive cure for this disease at present, there are numerous treatments available aimed at reducing the symptomatology of PD in addition to other therapeutic alternatives that are still under investigation. However, the therapeutic approach to this pathology should include a combination of pharmacological and non-pharmacological strategies to maximise outcomes and improve symptomatological control in these patients. It is therefore necessary to delve deeper into the pathophysiology of the disease in order to improve these treatments and therefore the quality of life of the patients.

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Section: Resultsmentioning

confidence: 99%

Current Treatments and New, Tentative Therapies for Parkinson’s Disease

Pardo-Moreno¹,

García‐Morales

Suleiman‐Martos

et al. 2023

Pharmaceutics

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“…Clements-Cortes et al (2016), in the context of music therapy, studied the potential of 40 Hz sensory brain stimulation in AD and Parkinson's Disease patients. More than 100 reviewed studies as well as the most recent reviews (Leggieri et al, 2019;Matziorinis and Koelsch, 2022) highlight the beneficial effect of music therapy for AD management and the slowdown of neurodegeneration (Matziorinis and Koelsch, 2022). In the same line, a recent meta-analysis (Lai et al, 2020) proposes music therapy as the best treatment for Mild Cognitive Impairment (MCI).…”

Section: Music As a Therapy In Alzheimer's Diseasementioning

confidence: 99%

Sensogenomics of music and Alzheimer’s disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics

Navarro

Gómez-Carballa

Pischedda

et al. 2023

Front. Aging Neurosci.

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IntroductionThe relationship between music and Alzheimer’s disease (AD) has been approached by different disciplines, but most of our outstanding comes from neuroscience.MethodsFirst, we systematically reviewed the state-of-the-art of neuroscience and cognitive sciences research on music and AD (>100 studies), and the progress made on the therapeutic impact of music stimuli in memory. Next, we meta-analyzed transcriptomic and epigenomic data of AD patients to search for commonalities with genes and pathways previously connected to music in genome association, epigenetic, and gene expression studies.ResultsOur findings indicate that >93% of the neuroscience/ cognitive sciences studies indicate at least one beneficial effect of music on patients with neurodegenerative diseases, being improvements on memory and cognition the most frequent outcomes; other common benefits were on social behavior, mood and emotion, anxiety and agitation, quality of life, and depression. Out of the 334 music-related genes, 127 (38%) were found to be linked to epigenome/transcriptome analysis in AD (vs. healthy controls); some of them (SNCA, SLC6A4, ASCC2, FTH1, PLAUR and ARHGAP26) have been reported to be associated e.g. with musical aptitude and music effect on the transcriptome. Other music-related genes (GMPR, SELENBP1 and ADIPOR1) associated to neuropsychiatric, neurodegenerative diseases and music performance, emerged as hub genes in consensus co-expression modules detected between AD and music estimulated transcriptomes. In addition, we found connections between music, AD and dopamine related genes, with SCNA being the most remarkable – a gene previously associated with learning and memory, and neurodegenerative disorders (e.g., Parkinson’s disease and AD).DiscussionThe present study indicate that the vast majority of neuroscientific studies unambiguously show that music has a beneficial effect on health, being the most common benefits relevant to Alzheimer’s disease. These findings illuminate a new roadmap for genetic research in neurosciences, and musical interventions in AD and other neurodegenerative conditions.

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“…Because cognitive dysfunction is associated with susceptibility to NPS, medications such as antipsychotics, antidepressants, hypnotics, and mood stabilizers are clinically used in patients with AD [86]. Non-drug therapies such as music therapy [87],…”

Section: Nps In Patients With Admentioning

confidence: 99%

The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy

Murayama

2023

Exp. Anim.

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Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Various hypotheses have been proposed to explain the development of AD. Some therapeutic agents have shown clinical benefits in patients with AD; however, many of these agents have failed.The degree of neural cell loss is associated with the severity of AD. Adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in AD model mice. Based on these clinical findings, stem cell therapy for patients with AD has recently attracted attention.This review provides past and present therapeutic strategies for the management and treatment of AD.

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The promise of music therapy for Alzheimer's disease: A review

Cited by 62 publications

References 86 publications

Current Treatments and New, Tentative Therapies for Parkinson’s Disease

Current Treatments and New, Tentative Therapies for Parkinson’s Disease

Sensogenomics of music and Alzheimer’s disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics

The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy

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