The promoter region of human prepro-nociceptin gene and its regulation by cyclic AMP and steroid hormones

Xie, Guoxi; Ito, Emi; Maruyama, Kazuo; Suzuki, Yutaka; Sugano, Sumio; Sharma, Manohar; Pietruck, Christian; Palmer, Pamela Pierce

doi:10.1016/s0378-1119(99)00350-9

Cited by 36 publications

(27 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in agreement with the result of a previous in vitro study, which has shown that estrogen up-regulates the transcription of the N/OFQ precursor (29). Human studies having been made so far have not found any signifi cant difference between male and female patients suffering from cluster headache or from bipolar disorders (10,26).…”

Section: Discussionsupporting

confidence: 92%

Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes

Csobay-Novák

Sótonyi

Krepuska

et al. 2012

Acta Physiologica Hungarica

View full text Add to dashboard Cite

Foregoing researches made on the N/OFQ system brought up a possible role for this system in cardiovascular regulation. In this study we examined how N/OFQ levels of the blood plasma changed in acute cardiovascular diseases. Three cardiac patient groups were created: enzyme positive acute coronary syndrome (EPACS, n = 10), enzyme negative ACS (ENACS, n = 7) and ischemic heart disease (IHD, n = 11). We compared the patients to healthy control subjects (n = 31). We found signifi cantly lower N/OFQ levels in the EPACS [6.86 (6.21-7.38) pg/ ml], ENACS [6.97 (6.87-7.01) pg/ml and IHD groups [7.58 (7.23-8.20) pg/ml] compared to the control group [8.86 (7.27-9.83) pg/ml]. A signifi cant correlation was detected between N/OFQ and white blood cell count (WBC), platelet count (PLT), creatine kinase (CK), glutamate oxaloacetate transaminase (GOT) and cholesterol levels in the EPACS group.Decreased plasma N/OFQ is closely associated with the presence of acute cardiovascular disease, and the severity of symptoms has a signifi cant negative correlation with the N/OFQ levels. We believe that the rate of N/OFQ depression is in association with the level of ischemic stress and the following infl ammatory response. Further investigations are needed to clarify the relevance and elucidate the exact effects of the ischemic stress on the N/OFQ system. Keywords: acute coronary syndrome, angina pectoris, nociceptin/orphanin FQ, ischemic stressMore than a decade now that a new chapter has been opened in the research of the opioid system with Mollereau cloning a new member of the opioid receptor family, which was named opioid receptor like orphan receptor (ORL-1) because it was reminiscent of the opioid receptors on both structural and functional ground (21). A year later the endogenous ligand of the ORL-1 was identifi ed and named nociceptin (for its hyperalgesic effect on mice when administered intracerebroventricularly) and orphanin-FQ, because of the Phe and Gln amino acids on the ends of the peptide chain (21, 22). The ORL-1 receptor was renamed NOP receptor and the nociceptin/orphanin FQ peptide as N/OFQ in the current nomenclature by NC-IUPHAR.

show abstract

Section: Discussionsupporting

confidence: 92%

Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes

Csobay-Novák

Sótonyi

Krepuska

et al. 2012

Acta Physiologica Hungarica

View full text Add to dashboard Cite

show abstract

“…Nociceptin acts as a modulator of spinal release of enkephalin, nociceptin receptors have been located in the superficial laminae (Gupta and Gintzler, 2003), and the prepronociceptin gene contains several ER-binding sites (Xie et al, 1999). Estrogens also affect the third classic endogenous Figure 7.…”

Section: Estrogen Receptor Neurons and The Endogenous Opioid Systemmentioning

confidence: 99%

Estrogenic influences in pain processing

Amandusson

Blomqvist

2013

Frontiers in Neuroendocrinology

111

View full text Add to dashboard Cite

Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.

show abstract

“…In humans, the N/OFQ gene has been mapped to the chromosomal location 8p21 [27] . Transcription of this gene was shown to be enhanced by cytokines, neurotrophic factors [26] , also by estrogen [28] . This cAMP-dependent transcription could be blocked by glucocorticoids [19] .…”

Section: Discussionmentioning

confidence: 99%