The properties of Gd2O3-assembled silica nanocomposite targeted nanoprobes and their application in MRI

Shao, Yuanzhi; Tian, Xiumei; Hu, Wenyong; Zhang, Yongyu; Liu, Huan; He, Hualiang; Shen, Yingying; Xie, Fei; Li, Li

doi:10.1016/j.biomaterials.2012.05.065

Cited by 72 publications

(58 citation statements)

References 41 publications

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“…23,24 On the basis of this mesoporous material preparation technology, we synthesized Gd-doped mesoporous silica MCM-41 (Gd 2 O 3 @MCM-41) nanoparticles, which had better efficacy than Gd-diethylenetriaminepentacetate, and systematically investigated their biocompatibility and biodistribution. 25 The detailed theoretical calculation was consistent with the results of the cytotoxicity and immunotoxicity assays, which showed that Gd 2 O 3 nanoclusters or Gd ions were hardly dissociated from the mesoporous silica structure and that the Gd 2 O 3 @MCM-41 nanocomposite could be developed as a potentially safe and effective MRI contrast agent. 25 In this study, we investigate the effects of Gd 2 O 3 @MCM-41 on the biological characteristics of labeled MSCs and NSCs and assess their tracking potential in murine transplant models.…”

Section: Introductionsupporting

confidence: 76%

“…25 The detailed theoretical calculation was consistent with the results of the cytotoxicity and immunotoxicity assays, which showed that Gd 2 O 3 nanoclusters or Gd ions were hardly dissociated from the mesoporous silica structure and that the Gd 2 O 3 @MCM-41 nanocomposite could be developed as a potentially safe and effective MRI contrast agent. 25 In this study, we investigate the effects of Gd 2 O 3 @MCM-41 on the biological characteristics of labeled MSCs and NSCs and assess their tracking potential in murine transplant models. These particles were found to have fairly low cytotoxicity against cell proliferation and had only a slight effect on the inherent differentiation potential of the labeled stem cells.…”

Section: Introductionsupporting

confidence: 76%

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Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo

Shen¹,

Shao²,

He³

et al. 2013

IJN

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Abstract:We investigated the tracking potential of a magnetic resonance imaging (MRI) probe made of gadolinium-doped mesoporous silica MCM-41 (Gd 2 O 3 @MCM-41) nanoparticles for transplanted bone mesenchymal stem cells (MSCs) and neural stem cells (NSCs) in vivo. The nanoparticles, synthesized using a one-step synthetic method, possess hexagonal mesoporous structures with appropriate assembly of nanoscale Gd 2 O 3 clusters. They show little cytotoxicity against proliferation and have a lower effect on the inherent differentiation potential of these labeled stem cells. The tracking of labeled NSCs in murine brains was dynamically determined with a clinical 3T MRI system for at least 14 days. The migration of labeled NSCs identified by MRI corresponded to the results of immunofluorescence imaging. Our study confirms that Gd 2 O 3 @MCM-41 particles can serve as an ideal vector for long-term MRI tracking of MSCs and NSCs in vivo.

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Section: Introductionsupporting

confidence: 76%

Section: Introductionsupporting

confidence: 76%

Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo

Shen¹,

Shao²,

He³

et al. 2013

IJN

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show abstract

“…nm can be excreted rapidly and efficiently by renal clearance, but those larger than 15 nm accumulate in the liver and spleen; 37,38 and 3) NPs easily accumulate in tumor due to the presence of endothelial gaps, high micro-vessel density, and high tumor blood flow. 36,39 Interestingly, the Gd-NPs accumulate in tumor tissues via capillaries and repeated blood circulation, and indicate a potential use for passive tumortargeting via the enhanced permeation and retention effect.…”

Section: Half-life Biodistribution and Excretion Of Gd-npsmentioning

confidence: 99%

“…Moreover, the dynamic enhancement curve of xenografted tumor and liver demonstrated a "fast-in and fast-out" pattern ( Figure 5B). 40 Based on our previous studies, 30,36,39 the optimized times for MRI imaging are a function of the probe and target tissue. Gd-DTPA quickly drops to baseline due to renal clearance.…”

Section: In Vivo Assessment Of Pharmacodynamics Of Gd-npsmentioning

confidence: 99%

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Toxicity evaluation of Gd2O3@SiO2 nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo

Tian¹,

Yang²,

Yang³

et al. 2014

IJN

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Poor toxicity characterization is one obstacle to the clinical deployment of Gd 2 O 3 @ SiO 2 core-shell nanoparticles (Gd-NPs) for use as magnetic resonance (MR) imaging contrast agents. To date, there is no systematic toxicity data available for Gd-NPs prepared by laser ablation in liquid. In this article, we systematically studied the Gd-NPs’ cytotoxicity, apoptosis in vitro, immunotoxicity, blood circulation half-life, biodistribution and excretion in vivo, as well as pharmacodynamics. The results show the toxicity, and in vivo MR data show that these NPs are a good contrast agent for preclinical applications. No significant differences were found in cell viability, apoptosis , and immunotoxicity between our Gd-NPs and Gd in a DTPA (diethylenetriaminepentaacetic acid) chelator. Biodistribution data reveal a greater accumulation of the Gd-NPs in the liver, spleen, lung, and tumor than in the kidney, heart, and brain. Approximately 50% of the Gd is excreted via the hepatobiliary system within 4 weeks. Furthermore, dynamic contrast-enhanced T1-weighted MR images of xenografted murine tumors were obtained after intravenous administration of the Gd-NPs. Collectively, the single step preparation of Gd-NPs by laser ablation in liquid produces particles with satisfactory cytotoxicity, minimal immunotoxicity, and efficient MR contrast. This may lead to their utility as molecular imaging contrast agents in MR imaging for cancer diagnosis.

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In Vivo Bio‐Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles

2013

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The remarkable progress of nanotechnology and its application in biomedicine have greatly expanded the ranges and types of biomaterials from traditional organic material-based nanoparticles (NPs) to inorganic biomaterials or organic/inorganic hybrid nanocomposites due to the unprecedented advantages of the engineered inorganic material-based NPs. Colloidal mesoporous silica NPs (MSNs), one of the most representative and well-established inorganic materials, have been promoted into biology and medicine, and shifted from extensive in vitro research towards preliminary in vivo assays in small-animal disease models. In this comprehensive review, the recent progresses in chemical design and engineering of MSNs-based biomaterials for in vivo biomedical applications has been detailed and overviewed. Due to the intrinsic structural characteristics of elaborately designed MSNs such as large surface area, high pore volume and easy chemical functionalization, they have been extensively investigated for therapeutic, diagnostic and theranostic (concurrent diagnosis and therapy) purposes, especially in oncology. Systematic in vivo bio-safety evaluations of MSNs have revealed the evidences that the in vivo bio-behaviors of MSNs are strongly related to their preparation prodecures, particle sizes, geometries, surface chemistries, dosing parameters and even administration routes. In vivo pharmacokinetics and pharmacodynamics further demonstrated the effectiveness of MSNs as the passively and/or actively targeted drug delivery systems (DDSs) for cancer chemotherapy. Especially, the advance of nano-synthetic chemistry enables the production of composite MSNs for advanced in vivo therapeutic purposes such as gene delivery, stimuli-responsive drug release, photothermal therapy, photodynamic therapy, ultrasound therapy, or anti-bacteria in tissue engineering, or as the contrast agents for biological and diagnostic imaging. Additionally, the critical issues and potential challenges related to the chemical design/synthesis of MSNs-based "magic bullet" by advanced nano-synthetic chemistry and in vivo evaluation have been discussed to highlight the issues scientists face in promoting the translation of MSNs-based DDSs into clinical trials.

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The properties of Gd2O3-assembled silica nanocomposite targeted nanoprobes and their application in MRI

Cited by 72 publications

References 41 publications

Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo

Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo

Toxicity evaluation of Gd2O3@SiO2 nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo

In Vivo Bio‐Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles

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