The Prophylactic Antiemetic Effect of Droperidol

Patton, Clifton M.; Moon, Michael R.; Dannemiller, Francis J.

doi:10.1213/00000539-197405000-00011

Cited by 34 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40,46,50,53,54,59,61,83,84,88,96,98,105,107,109 Some trials reported late incidences of nausea or vomiting with placebo below the 40% or above the 80% boundary, respectively. 38,39,42,70,78,91,93 Data from these trials were excluded from the sensitivity analysis with truncated control event rates (Table IIa). In both adults and children, results on dose-responsiveness were maintained despite restriction of the analysed data to a predefined range of control event rates.…”

Section: Sensitivity Analysesmentioning

confidence: 99%

Efficacy, dose-response, and adverse effects of droperidol for prevention of postoperative nausea and vomiting

Henzi

Sonderegger

Tramèr

2000

Can J Anesth/J Can Anesth

217

View full text Add to dashboard Cite

Purpose: To estimate the efficacy and harm produced by droperidol in the prevention of postoperative nausea and vomiting (PONV). Methods: Systematic search (MEDLINE, EMBASE, Cochrane library, hand-searching, bibliographies, all languages, up to May 1999) for randomised comparisons of droperidol with placebo in surgical patients. Relevant end points were prevention of early PONV (up to six hours postoperatively), and late PONV (24 hr), and adverse effects. Combined data were analysed using relative risk and NNT. Results: In 76 trials, 5,351 patients received 24 different regimens of droperidol. The average incidence of early and late PONV in controls was 34% and 51%, respectively. Droperidol was more efficacious than placebo in preventing PONV. In adults, the anti-nausea effect was short-lived, and there was no dose-responsiveness; with 0.25 to 0.30 mg the number-needed-to-treat (NNT) to prevent early nausea was 5. For both early and late anti-vomiting efficacy there was dose-responsiveness; best efficacy was with 1.5 mg to 2.5 mg (NNT, 7). In children, there was dose-responsiveness; best efficacy was with 75 µg·kg -1 (NNT to prevent early and late vomiting, 4). Two children had extrapyramidal symptoms with droperidol (NNT in children, 91; in any patient, 408). There was dose-responsiveness for sedation and drowsiness (with 2.5 mg the NNT was 7.8). Droperidol prevented postoperative headache (NNT,. Conclusions: Droperidol is anti-emetic in the surgical setting. The effect on nausea is short-lived but more pronounced than the effect on vomiting. Sedation and drowsiness are dose-dependent, extrapyramidal symptoms are rare, and there is a protective effect against headache.Objectif : Évaluer l'efficacité et les effets négatifs du dropéridol utilisé pour la prévention de nausées et de vomissements postopératoires (NVPO). Méthode : Recherche documentaire systématique (MEDLINE, EMBASE, bibliothèque Cochrane, recherche manuelle, bibliographies, dans toutes les langues jusqu'à mai 1999) pour établir des comparaisons randomisées de dropéridol avec un placebo chez des patients de chirurgie. Les paramètres étudiés ont été la prévention des NVPO précoces (jusqu'à six heures après l'opération) et tardifs (24 h) et les effets indésirables. Les données combinées ont été analysées en utilisant le risque relatif et le nombre nécessaire au traitement (NNT). Résultats : Résultats : Pour 76 essais, 5 351 patients ont reçu 24 régimes différents de dropéridol. L'incidence moyenne de NVPO précoces et tardifs chez les témoins a été de 34 % et 51 %, respectivement. Le dropéridol a été plus efficace que le placebo pour prévenir les NVPO. Chez les adultes, l'effet anti-nausée a été de courte durée et il n'y a pas eu de réponse en fonction de la dose; avec 0,25 à 0,30 mg, le NNT pour prévenir les nausées précoces a été de 5. Pour prévenir efficacement les vomissements précoces et tardifs, il y avait une réponse dépendante de la dose; la plus efficace a été de 1,5 mg à 2,5 mg (NNT, 7). Chez les enfants, pas de réponse selon la dose; l'effica...

show abstract

Section: Sensitivity Analysesmentioning

confidence: 99%

Efficacy, dose-response, and adverse effects of droperidol for prevention of postoperative nausea and vomiting

Henzi

Sonderegger

Tramèr

2000

Can J Anesth/J Can Anesth

217

View full text Add to dashboard Cite

show abstract

“…It has been shown to be effective in a range of doses, although the duration of action of a single bolus is limited to several hours. 6 The delivery of opioid.analgesics using patient-controlled analgesia (PCA)systems provides effective pain control with a high degree of patient satisfaction. 7.8 However, this method of administration has not been found to reduce the incidence of nausea compared with fixed interval intramuscular injections.…”

Section: Conclusion: Le Drop~ridol 1 Mg Avant L'induction Diminue Lesmentioning

confidence: 99%

Reduction of post-operative nausea and vomiting with the combination of morphine and dropéridol in patient-controlled analgesia

et al. 1996

View full text Add to dashboard Cite

show abstract

“…Chest wall rigidity has also been re ported with fentanyl use [4]. Droperidol is a neuroleptic agent which has potent sedative, analgesic, and antiemetic properties [2,3]. Adverse symptoms associated with its use include dysphoric reactions and extrapyramidal Parkinsonism-like activity [3].…”

Section: Discussionmentioning

confidence: 99%

Sedation for Stereotactic Headframe Application: A Randomized Comparison of Two Techniques

Lanier

Hool²,

Faust³

et al. 1987

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

A prospective, randomized study was performed in 87 patients to compare the safety, efficacy and dose requirements of two sedation techniques for stereotactic headframe application. Sedation administration and headframe application averaged 30 min. Fifty patients weighing 76 ± 13 kg (mean ± SD) received mean doses of 154 µg fentanyl plus 5.5 mg droperidol i.v. (FD group). An additional 37 patients weighing 76 ± 19 kg received mean doses of 127 µg fentanyl plus 6.7 mg Valium® (diazepam; FV group). Both treatments provided excellent hemodynamic stability and a Iow incidence of adverse side effects while providing adequate analgesia and sedation. The incidence of anesthetist-assessed patient anxiety and discomfort was more favorable in the FD group.

show abstract

The Prophylactic Antiemetic Effect of Droperidol

Cited by 34 publications

References 0 publications

Efficacy, dose-response, and adverse effects of droperidol for prevention of postoperative nausea and vomiting

Efficacy, dose-response, and adverse effects of droperidol for prevention of postoperative nausea and vomiting

Reduction of post-operative nausea and vomiting with the combination of morphine and dropéridol in patient-controlled analgesia

Sedation for Stereotactic Headframe Application: A Randomized Comparison of Two Techniques

Contact Info

Product

Resources

About