The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats

Fan, Zhexin; Yang, Bo; Ross, R. Paul; Stanton, Catherine; Zhao, Jianxin; Zhang, Hao

doi:10.1039/c9fo02556a

Cited by 27 publications

(20 citation statements)

References 61 publications

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“…Several Lactobacillus spp., especially L. casei, L. reuteri, L. fermentum and L. rhamnosus reduced collagen-induced-arthritis (CIA) in female Wistar rats by modifying gut microbial population (increasing Lactobacillus spp. ), preventing proinflammatory cytokines, releasing antibodies, antibiotic substances and short-chain fatty acids, or modulating Th1/Th17 responses [ 90 ]. Noticeably, these effects are species dependent.…”

Section: Roles Of Lactobacillus Probiotics Against Ra In Preclinical Studiesmentioning

confidence: 99%

Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus

Paul

Jahan

et al. 2021

Microorganisms

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Rheumatoid arthritis is a chronic autoimmune disorder that can lead to disability conditions with swollen joints, pain, stiffness, cartilage degradation, and osteoporosis. Genetic, epigenetic, sex-specific factors, smoking, air pollution, food, oral hygiene, periodontitis, Prevotella, and imbalance in the gastrointestinal microbiota are possible sources of the initiation or progression of rheumatoid arthritis, although the detailed mechanisms still need to be elucidated. Probiotics containing Lactobacillus spp. are commonly used as alleviating agents or food supplements to manage diarrhea, dysentery, develop immunity, and maintain general health. The mechanism of action of Lactobacillus spp. against rheumatoid arthritis is still not clearly known to date. In this narrative review, we recapitulate the findings of recent studies to understand the overall pathogenesis of rheumatoid arthritis and the roles of probiotics, particularly L. casei or L. acidophilus, in the management of rheumatoid arthritis in clinical and preclinical studies.

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Section: Roles Of Lactobacillus Probiotics Against Ra In Preclinical Studiesmentioning

confidence: 99%

Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus

Paul

Jahan

et al. 2021

Microorganisms

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“…To regulate gut microbial balance, many approaches, such as prebiotic supplement and probiotic treatment, have been applied to both animal experiments and clinical trials [11,12]. Particularly, probiotics, severing as a common gut microbial regulator, affect the gut microbial diversity, structure, and composition.…”

Section: Introductionmentioning

confidence: 99%

The Potential Role of Probiotics in Protection against Influenza a Virus Infection in Mice

Liu

Fang

Liu

et al. 2021

Foods

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Influenza A virus induces severe respiratory tract infection and results in a serious global health problem. Influenza infection disturbs the cross-talk connection between lung and gut. Probiotic treatment can inhibit influenza virus infection; however, the mechanism remains to be explored. The mice received Lactobacillus mucosae 1025, Bifidobacterium breve CCFM1026, and their mixture MIX for 19 days. Effects of probiotics on clinical symptoms, immune responses, and gut microbial alteration were evaluated. L. mucosae 1025 and MIX significantly reduced the loss of body weight, pathological symptoms, and viral loading. B. breve CCFM1026 significantly reduced the proportion of neutrophils and increased lymphocytes, the expressions of TLR7, MyD88, TRAF6, and TNF-α to restore the immune disorders. MIX increased the antiviral protein MxA expression, the relative abundances of Lactobacillus, Mucispirillum, Adlercreutzia, Bifidobacterium, and further regulated SCFA metabolism resulting in an enhancement of butyrate. The correlation analysis revealed that the butyrate was positively related to MxA expression (p < 0.001) but was negatively related to viral loading (p < 0.05). The results implied the possible antiviral mechanisms that MIX decreased viral loading and increased the antiviral protein MxA expression, which was closely associated with the increased butyrate production resulting from gut microbial alteration.

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“…The collagen-induced arthritis (CIA) model is the most typical in vivo model of arthritis in which CIA susceptible DBA/1 mouse is used [50,51]. L. salivarius delays the onset of CIA, while it shows no relief from the severity of CIA [37]. Interestingly, in this study, although it was not effective in the reduction of arthritis incidence, oral administration of P. freudenreichii MJ2 alleviated arthritic scores such as swelling of paw and degree of redness.…”

Section: Discussionmentioning

confidence: 62%

“…Among them, Lactobacillus and Bifidobacterium species are the main probiotics that have been extensively studied [34][35][36]. Lactobacilli show a protective effect against CIA and interestingly, their ability to alleviate RA are different according to the species [37]. L. casei, L. rhamnosus, and L. fermentum protect RA through modulating immune response and rebalancing gut microbiota, while L. salivarius delays the development of RA without affecting immune response.…”

Section: Discussionmentioning

confidence: 99%

Propionibacterium freudenreichii Inhibits RANKL-Induced Osteoclast Differentiation and Ameliorates Rheumatoid Arthritis in Collagen-Induced Arthritis Mice

Yeom

Yim

et al. 2021

Microorganisms

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Osteoclast differentiation is crucial for bone absorption, and osteoclasts are involved in bone destruction in rheumatoid arthritis (RA). Dairy Propionibacterium freudenreichii is used as a cheese starter and possesses prebiotic and postbiotic properties. It is known to stimulate the growth of bifidobacteria and produces valuable metabolites, such as vitamin B12 and propionic acid. However, limited information is available on the beneficial effects of P. freudenreichii on human disease. Herein, we aimed to investigate the inhibitory effect of P. freudenreichii MJ2 (MJ2) isolated from raw milk on osteoclast differentiation and evaluate the improvement in RA. The murine macrophage cell line, RAW 264.7, and a collagen-induced arthritis (CIA) mouse model were used to perform in vitro and in vivo studies, respectively. Heat-killed P. freudenreichii MJ2 (hkMJ2)-treated cells significantly inhibited RANKL-induced osteoclast differentiation and TRAP activity. HkMJ2-treated cells exhibited significantly decreased expression of genes and proteins related to RANKL-induced osteoclast differentiation. MJ2 administration decreased the arthritic score in the CIA mouse model. Live and dead MJ2 inhibited bone loss and afforded protection against bone erosion and joint damage in CIA mice. MJ2 decreased the levels of collagen-specific antibodies and inflammatory cytokines and the expression of osteoclast differentiation-related genes and proteins in CIA mice. Interestingly, live and dead MJ2 showed similar RA improvement effects in CIA mice. In conclusion, P. freudenreichii MJ2 inhibited osteoclast differentiation by inhibiting the NF-κB signaling pathway and ameliorated CIA.

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The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats

Abstract: The current study evaluated the prophylactic effects of different Lactobacillus species on arthritis induced by collagen.

Cited by 27 publications

References 61 publications

Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus

Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus

The Potential Role of Probiotics in Protection against Influenza a Virus Infection in Mice

Propionibacterium freudenreichii Inhibits RANKL-Induced Osteoclast Differentiation and Ameliorates Rheumatoid Arthritis in Collagen-Induced Arthritis Mice

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