Background: COVID-19 pandemic has caused a tidal wave of anxiety and stress among Iranians, especially pregnant women. In order to control this unpleasant situation, it is indispensable to examine such issues as the level of Knowledge, emotions, and health behaviors. This study aimed to assess the association between knowledge, perceived severity, and perceived controllability of covid-19 with emotional and behavioral reactions in pregnant women.Methods: This cross-sectional study was performed on 440 pregnant women who were selected via the multistage sampling method from four different cities of Sistan-Baluchestan province, Iran. Data were collected using demographic-obstetrics characteristics form, as well as the questionnaires of knowledge, perceived severity, and perceived controllability of the COVID-19, health anxiety, and self-care. Results: Based on the results, self-care was positively correlated with knowledge, perceived severity, and perceived controllability of the COVID-19. Nonetheless, health anxiety had a significant and inverse association with knowledge and perceived controllability, while there was a positive and significant correlation between perceived severity and health anxiety. Based on linear regression, three variables of knowledge, perceived severity, and perceived controllability of the COVID-19 could explain 46.3 and 17.5 % of variations in self-care and health anxiety, respectively. Finally, people with higher education and knowledge obtained higher scores on self-care and lower scores on health anxiety.Conclusion: As evidenced by the obtained results, it is suggested that due to the critical importance of prenatal care, managers, and health officials promote the use of such methods as telehealth and home-based caregivers, especially in areas with inadequate access to health care. In so doing, the pregnant women can be followed up and receive medical care devoid of any stress and anxiety and without a physical presence in healthcare centers.