The Protective Action of Melatonin in Gastroesophageal Reflux Disease

Karpovich, A. A.; Shyshko, V. I.

doi:10.25298/2616-5546-2019-3-1-61-65

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…It was found that OSAGS negatively affects the course of GERD, as it increases the frequency and duration of reflux from the stomach into the esophagus, aggravates damage to its mucous membrane and increases the risk of developing Barrett's esophagus [5,6].…”

Section: Introductionmentioning

confidence: 99%

The Role of Quality of Life in Melatonin Content as a Regulator of Defense and Aggression Factors in Gastroesophageal Reflux Disease Patients With Sleep Apnea Syndrome

Oparin

Murghuzov

2021

Eureka: HS

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The aim of the study: to study the effect of the quality of life on the melatonin content, and at the same time to assess the state of the factors of aggression and protection of the esophageal mucosa in patients with GERD without comorbidities and with concomitant obstructive sleep apnea/hypopnea syndrome (OSAHS). Methods. 45 patients were taken for the study. 23 of them had GERD concomitant COPD, 22 were with isolated GERD with a non-erosive form. Melatonin levels were determined using the enzyme immunoassay method (ELIZA). Quality of life was assessed using the SF-36 questionnaire. Antioxidant protection of the mucous membrane (protection factor) – was assessed by the activity of superoxide dismutase (SOD). SOD activity in blood serum was determined by calorimetric method. Determination of the DC level was carried out in the blood by the spectrofluorimetric method. Results. The study showed that in patients with GERD with concomitant COPD, there is a significant decrease in the indicators of antioxidant activity and melatonin, both with indicators from the control group and with indicators of patients with GERD without comorbidity. At the same time, in patients with GERD without comorbidities, an increase in the level of DC was observed in comparison with the control group and patients with GERD with concomitant pathology and acidity of gastric juice. When analyzing the indicators of QOL in patients with GERD with concomitant pathology, there is a significantly more pronounced decrease in mental health, role emotional functioning and vitality. Conclusions. It has been established that in patients with GERD in the stage of exacerbation of the disease, there is a statistically significant decrease in QOL indicators with a high degree of reliability, manifesting itself in patients without combined pathology in the spectrum of indicators of the physical component of health, and in patients with GERD with concomitant obstructive sleep syndrome – in the spectrum of the psychological component quality of life. It has been shown that with a decrease in QOL in patients with GERD, the level of melatonin decreases, the decrease in which more clearly increases in patients with concomitant obstructive sleep apnea. Simultaneously with a drop in the level of melatonin in patients with GERD without associated pathology, the aggression factor increases with a high degree of certainty - that is, a decrease in the pH of gastric juice and an increase in the content of DC, while in patients with GERD with concomitant sleep apnea syndrome, the factor decreases with a high degree of certainty. Protection of the esophageal mucosa – (that is, a decrease in SOD activity), which must be taken into account when treating this category of patients.

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Section: Introductionmentioning

confidence: 99%

The Role of Quality of Life in Melatonin Content as a Regulator of Defense and Aggression Factors in Gastroesophageal Reflux Disease Patients With Sleep Apnea Syndrome

Oparin

Murghuzov

2021

Eureka: HS

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The role of melatonin in the complex treatment of patients with gastroesophageal reflux disease with sleep apnea syndrome

Oparin¹,

Murghuzov²

2020

Shidnoevr. z. vnutr. simejnoi med.

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Features of the Expression of Second-Type Melatonin Receptors by Esophagus Epiteliocytes in Gastroesophageal Reflux Disease

Карпович

Штабинская

Шишко

et al. 2020

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. To investigate the specific features of the expression of second-type melatonin receptors (MTNR1B) by epithelial cells of the distal esophagus in gastroesophageal reflux disease (GERD), depending on the severity of endoscopic changes in the mucous membrane.Materials and methods. The study included 48 GERD patients, out of whom 37 and 11 people were suffering from non-erosive reflux disease (NERD) and erosive reflux disease (ERD), respectively. The control group consisted of 18 patients without GERD, comparable with the main groups by gender, age and body mass index. In order to determine the expression of MTNR1B, esophagogastroduodenoscopy with the collection of biopsy material from the mucous membrane of the distal esophagus was performed. The quantification of the MTNR1B expression intensity was carried out using the Aperio ImageScope_v9.1.19.1567 software. The level of melatonin metabolite, 6-sulphatehydroxymelatonin (6-SOMT), was determined in daily urine, as well as separately in daytime and nighttime portions.Results. The intensity of MTNR1B expression by esophageal epithelial cells in patients with NERD demonstrated no difference with the control group (0.436 (0.123, 0.668) and 0.437 (0.202, 0.692), respectively; p> 0.05). A significant decrease in the expression of MTNR1B receptors was noted in patients with ERD compared to NERD patients (0.127 (0.059, 0.156) and 0.436 (0.123, 0.668), respectively; p = 0.017) and patients in the control group (0.437 (0.202, 0.692); p = 0.033). The low intensity of MTNR1B expression was associated with more pronounced endoscopic changes in the mucous membrane of the esophagus (r = –0.40; p = 0.0015). A statistically significant relationship was found between the expression intensity of MTNR1B and the level of melatonin in the daytime (r = 0.42; p = 0.018), as well as the night/day index reflecting the daily rhythm of melatonin synthesis (r = –0.43; p = 0.016).Conclusions. The obtained data indicate that a decrease in the intensity of MTNR1B expression by esophageal epithelial cells can be considered as a prognostically unfavourable sign of the GERD course. The low intensity of MTNR1B expression is associated with a more severe (erosive) form of GERD and more pronounced endoscopic changes in the mucous membrane of the esophagus.

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The Protective Action of Melatonin in Gastroesophageal Reflux Disease

Cited by 3 publications

References 4 publications

The Role of Quality of Life in Melatonin Content as a Regulator of Defense and Aggression Factors in Gastroesophageal Reflux Disease Patients With Sleep Apnea Syndrome

The Role of Quality of Life in Melatonin Content as a Regulator of Defense and Aggression Factors in Gastroesophageal Reflux Disease Patients With Sleep Apnea Syndrome

The role of melatonin in the complex treatment of patients with gastroesophageal reflux disease with sleep apnea syndrome

Features of the Expression of Second-Type Melatonin Receptors by Esophagus Epiteliocytes in Gastroesophageal Reflux Disease

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