The protective effect of Boswellic acid and Ellagic acid loaded, colon targeted, and pH-sensitive N-succinyl chitosan in ulcerative colitis rat model

Yi̇pel, Mustafa; Tekeli, İbrahim Ozan; Altınok-Yipel, Fulya; Coşkun, Pınar; Aslan, Abdullah Nabi; Güvenç, Mehmet; Beyazit, Neslihan; Özsoy, Şule Yurdagül

doi:10.1016/j.jddst.2021.103023

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…In this context, EA-enriched pomegranate extract markedly decreased COX-2 and iNOS overexpression, reduced MAPKs phosphorylation, and prevented nuclear NF-κB translocation, thereby attenuated chronic colonic inflammation [84]. In an ulcerative colitis model induced by acetic acid in rats, EA administration decreased the protein levels of TNF-α, COX-2, and NF-κB, and thereby exerted protective effects on colonic inflammation [82]. In the acute DSS-induced mice colitis model, EA attenuated colitis severity slightly through the reduction of inflammatory mediators (IL-6, TNF-α, and IFN-γ) [83].…”

Section: Ellagic Acid (Ea)mentioning

confidence: 97%

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

Wang

Yang

2022

IJMS

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TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 (TLR4), the first mammalian TLR to be characterized, is the innate immune receptor that plays a key role in inflammatory signal transductions. Nuclear factor kappa B (NF-κB), the TLR4 downstream, is the key to accounting for the expression of multiple genes involved in inflammatory responses, such as pro-inflammatory cytokines. Inflammatory bowel disease (IBD) in humans is a chronic inflammatory disease with high incidence and prevalence worldwide. Targeting the TLR4/NF-κB signaling pathway might be an effective strategy to alleviate intestinal inflammation. Polyphenol phytochemicals have shown noticeable alleviative effects by acting on the TLR4/NF-κB signaling pathway in intestinal inflammation. This review summarizes the pharmacological effects of more than 20 kinds of polyphenols on intestinal inflammation via targeting the TLR4/NF-κB signaling pathway. We expected that polyphenol phytochemicals targeting the TLR4/NF-κB signaling pathway might be an effective approach to treat IBD in future clinical research applications.

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Section: Ellagic Acid (Ea)mentioning

confidence: 97%

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

Wang

Yang

2022

IJMS

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Phenolic acids as potent antioxidant agents

Tutun,

Yipel

2024

Advancement of Phenolic Acids in Drug Discovery

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Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions

Quiroga,

Coy-Barrera

2024

MRMC

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Abstract:: Chitosan (CS) is a polymer made up of mainly deacetylated β-1,4 D-glucosamine units, which is part of a large group of D-glucosamine oligomers known as chitooligosaccharides, which can be obtained from chitin, most abundant natural polymer after cellulose and central component of the shrimp exoskeleton. It is known that it can be used for the development of materials, among which its use stands out in wastewater treatment (removal of metal ions, dyes, and as a membrane in purification processes), food industry (anti-cholesterol and fat, packaging material, preservative, and food additive), agriculture (seed and fertilizer coating, controlled release agrochemicals), pulp and paper industry (surface treatment, adhesive paper), cosmetics (body creams, lotions, etc.), in the engineering of tissues, wound healing, as excipients for drug administration, gels, membranes, nanofibers, beads, microparticles, nanoparticles, scaffolds, sponges, and diverse biological ones, specifically antibacterial and antifungal activities. This article reviews the main contributions published in the last ten years regarding the use and application of CS in medical chemistry. The applications exposed here involve regenerative medicine in the design of bioprocesses and tissue engineering, Pharmaceutical sciences to obtain biomaterials, polymers, biomedicine, and the use of nanomaterials and nanotechnology, toxicology, and Clinical Pharmaceuticals, emphasizing the perspectives and the direction that can take research in this area.

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The protective effect of Boswellic acid and Ellagic acid loaded, colon targeted, and pH-sensitive N-succinyl chitosan in ulcerative colitis rat model

Cited by 3 publications

References 47 publications

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

Phenolic acids as potent antioxidant agents

Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions

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