The protective effect of ClinOleic against post-surgical adhesions

Altınel, Yüksel; Taşpinar, Ersoy; Özgüç, Halil; Öztürk, Ersin; Akyıldız, Elif Ülker; Bağdaş, Deniz

doi:10.5505/tjtes.2014.12244

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…Additionaly the anti-inflammatory effect of fatty acids, Jiang et al reported that γ-tocopherol inhibits proinflammatory PGE2 and LTB4, decreases TNF-alpha, and γ-tocopherol shows antiinflammatory effect [7][8][9][10][11]22]. Giant cells are seen in granulamatous inflammation that is different patern of chronic inflammatory reaction and generally occurs due to foreign bodies [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Argan oil reduced adhesion formation with its liquid form like as soybean oil, olive oil, omega 3 fatty acids [7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…Barriers, surgical or non invasive strategies, cellular strategies, drugs and agents have been used at clinical or experimental studies [6]. Fatty acids contents such as soybean oil, ClinOleic, canola oil, omega 3 fatty acids and olive oil were studied for prevention of PPA experimentally in literature [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Anti-adhesive effects of argan oil on postoperative peritoneal adhesions

Aydın¹,

Karakaş²,

Hazer³

et al. 2018

Med-Science

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The aim of this study is to reveal effect of Argan oil on postoperative peritoneal adhesion. Twenty-four Wistar albino rats were divided into three groups. After laparotomy was carried out intraperitoneally, 0,9% NaCl and 3 ml Argan Oil applied to saline and Argan oil groups, respectively. Four subjects in each groups were sacrificed at postoperative day 3 and 7. Macroscopic adhesions and microscopic cellular reactions, such as giant cell, lymphocyte/plasmocyte, neutrophil and histiocyte, were assessed and hydroxyproline levels were measured in all three groups. Adhesion and fibrosis scores were lower both 3rd and 7th days in Argan oil, but only lower fibrosis scores were statistically significant (p<0,05). Except giant cell 3th day scores; Argan oil had lowest neutrophil, lymphocyte, plasmocyte, and histiyocyte scores. Both 3rd and 7th days scores of neutrophil, lymphocyte, plasmocyte, but only 7th days scores of histiocyte reaction were statistically significant (p<0,05). However; Argan oil had highest hydroxyproline levels and the difference were not statistically significant both 3rd and 7th days (p>0,05). Argan oil reduced the postoperative peritoneal adhesions initially seperation the damaged tissues, subsequent effects of fatty acids and tocopherols on inflammation, plasminogen activation and matrix metalloproteinase steps of adhesion formation.

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Section: Discussionmentioning

confidence: 99%

“…Argan oil reduced adhesion formation with its liquid form like as soybean oil, olive oil, omega 3 fatty acids [7][8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

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Anti-adhesive effects of argan oil on postoperative peritoneal adhesions

Aydın¹,

Karakaş²,

Hazer³

et al. 2018

Med-Science

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“…Laparoscopy has fewer potential complications than laparotomy [20], such as adhesions, intestinal obstruction, infertility, and chronic pelvic pain [2,9]. CO 2 insufflation for good visualization during surgery causes hypoxic and splenic ischemia and triggers peritoneal adhesion [9,21].…”

Section: Discussionmentioning

confidence: 99%

The effect of laparoscopy on mast cell degranulation and mesothelium thickness in rats

Poerwosusanta

Gunadi²,

Noor

et al. 2020

BMC Surg

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Background: Laparoscopy induces adhesion due to ischemia-reperfusion injury. However, the detail pathomechanism is poorly understood. This study aimed to investigate the impact of laparoscopy on mast cell and mesothelium morphological changes in the rat. Methods: Forty-nine males of Sprague-Dawley Rattus norvegicus were divided into four groups: a) control and b) intervention groups P1, P2, and P3 that underwent 60 min laparoscopic using carbon dioxide (CO 2) insufflation at 8, 10, and 12 mmHg groups, respectively. Serum hydrogen peroxide (H 2 O 2), catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), and oxidative stress index (OSI) levels were determined 24 h after laparoscopy. Histopathological analyses of mast cell infiltration and degranulation and mesothelium thickness in the liver, greater omentum, mesenterium, small intestine, and peritoneum were performed 7 days after the procedure. Results: H 2 O 2 , MDA, and OSI levels were significantly increased in the intervention groups compared with the control (p<0.05), while the SOD and CAT levels were decreased in the intervention groups compared with the control (p<0.05). Mast cell infiltration and degranulation were higher in the intervention groups than in control (p< 0.05), while the mesothelium thickness was significantly lower in the laparoscopic groups than in control (p<0.05). Interestingly, the decrease in mesothelium thickness was strongly associated with the increase in mast cell infiltration and degranulation (p<0.01). Conclusions: Our study shows that laparoscopy in rats increases mast cell infiltration and degranulation, which also results in and correlates with a decrease in mesothelial thickness.

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“…Regarding the mechanism of adhesion formation, fibrinolysis and extracellular matrix remodeling, including cell proliferation, migration, differentiation, angiogenesis, and apoptosis, are critical for the regulation of the adhesive process as controlling inflammation at initial stages (7,13,14).…”

Section: Discussionmentioning

confidence: 99%

A novel coenzyme-Q approach for the prevention of postsurgical adhesion

et al. 2020

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Objective: Postoperative intraperitoneal adhesions are an unsolved and important problem in abdominal surgery. In the present study, the probable preventive role of coenzyme-Q in the development of peritoneal adhesions was investigated. Material and Methods: Sixteen Wistar Hannover male rats weighing 300-350 g were randomly separated into two groups of 8 rats each. The cecum was abraded with a sterile gauze until sub-serosal hemorrhage developed. A patch of peritoneum located opposite to the cecal abrasion was completely dissected. No treatment was given to Group 1. Group 2 received 30 mg/kg coenzyme-Q, which was injected 2 mL intraperitoneally. All the rats were sacrificed on the postoperative 21 st day, and after adhesions were scored macroscopically, tissue specimens of the peritoneum and bowel were subjected to histopathological investigation. Tissue and blood specimens were also taken for biochemical analysis to investigate antioxidant efficiency. Results: Adhesion scores were significantly different between the control group and the coenzyme-Q group (p= 0.001). According to the tissue levels of GSH-Px, MDA, and SOD levels, there was no significant difference between the study groups (p= 0.074, p= 0.208, p= 0.526). According to the plasma GSH-Px and SOD levels, there was significant difference between the groups (p= 0.002, p= 0.001), but the difference was not significant at MDA levels (p= 0.793). The differences between the pathological scores of the control and coenzyme-Q (p= 0.028 for fibrosis; p= 0.025 for inflammation) groups were statistically significant. Conclusion: This study confirms that coenzyme-Q is the potential application in the prevention of early postoperative adhesions.

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The protective effect of ClinOleic against post-surgical adhesions

Abstract: BACKGROUND: Although the English-language literature is full of studies about post-surgical adhesions, no definitive method has yet been identified to prevent them. The goal of this study was to investigate the effect of ClinOleic on reducing post-surgical adhesion formation.

Cited by 6 publications

References 29 publications

Anti-adhesive effects of argan oil on postoperative peritoneal adhesions

Anti-adhesive effects of argan oil on postoperative peritoneal adhesions

The effect of laparoscopy on mast cell degranulation and mesothelium thickness in rats

A novel coenzyme-Q approach for the prevention of postsurgical adhesion

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