The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice

Wang, Jinchun; Wang, Lei; Zhou, Jie; Qin, Aiping; Chen, Zhujing

doi:10.1016/j.biopha.2018.07.063

Cited by 60 publications

(42 citation statements)

References 28 publications

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“…A Chinese herb‐derived compound known as chrysophenol proved to be beneficial by ameliorating cognitive deficits in diabetic mice (Chu et al, ). Recently, a phytoestrogen named formononetin showed improvement in memory when assessed by behavioral studies and also reduced inflammation and oxidative stress, which suggests its neuroprotective action in the animal model of diabetes (Wang, Wang, et al, ). Vanadium is a nutritional element found in nature and is well reported for its potential in treatment of diabetes.…”

Section: Curing Diabetes Associated Alzheimer's Disease: a Long Way Tmentioning

confidence: 99%

“…It was observed in one study that the impairment in crosstalk between Schwann cells and axons could be involved in complicating diabetic neuropathy (Feldman, Nave, Jensen, & Bennett, ). In a study carried out on the neurons of db/db mice, it was observed that the pain caused in this condition involves AMP‐activated protein kinase enzyme which upon high glucose increases the expression of transient receptor potential ankyrin 1 (TRPA1), which ultimately mediates pain transduction in diabetic neuropathy (Wang, Wang, Zhou, Qin, & Chen, ). To develop therapeutics, compounds like rutin, curcumin derivative J147, berberine, deguelin, and secretoneurin have been recently tested in animals in which they showed amelioration of diabetic neuropathy (Chen et al, ; Lv, Cao, Zhang, Bai, & Wei, ; Theurl et al, ; Tian et al, ; Zan, Kuai, Qiu, & Huang, ).…”

Section: Introductionmentioning

confidence: 99%

“…Alzheimer's disease is the major reason behind dementia which not only affects the quality of life of the individual suffering from AD but also of the family members and becomes difficult to manage on its progression. If early stage of AD is considered, then there is a study which suggests protective role of frontal regions of brain in response to the pathology (Lin et al, 2017, Wang, Wang, Zhou, Qin, & Chen, 2018.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease

Jash

Gondaliya

Kirave

et al. 2019

Drug Development Research

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Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting millions of people worldwide. Diabetes is associated with various complications like nephropathy, neuropathy, retinopathy, diabetic foot, cognitive impairment, and many more. Evidence suggests that cognitive dysfunction is a rising complication of diabetes which adversely affects the brain of patients suffering from diabetes. Age‐related memory impairment is a complication having its major effect on people suffering from diabetes and Alzheimer's. Patients suffering from diabetes are at two times higher risk of developing cognitive dysfunction as compared with normal individuals. Multiple factors which are involved in diabetes related complications are found to play a role in the development of neurodegeneration in Alzheimer's. The problem of insulin deficiency and insulin resistance is well reported in diabetes but there are many studies which suggest dysregulation of insulin levels as a reason behind the development of Alzheimer's. As the link between diabetes and Alzheimer disease (AD) is deepening, there is a need to understand the plausible tie‐ins between the two. Emerging role of major factors like insulin imbalance, advanced glycation end products and micro‐RNA's involved in diabetes and Alzheimer's have been discussed here. This review helps in understanding the plausible mechanism underlying the pathophysiology of amyloid beta (Aβ) plaque formation and tau hyperphosphorylation as well provides information about studies carried out in this area of research. The final thought is to enhance the scientific knowledge on this correlation and develop future therapeutics to treat the same.

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Section: Curing Diabetes Associated Alzheimer's Disease: a Long Way Tmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease

Jash

Gondaliya

Kirave

et al. 2019

Drug Development Research

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show abstract

“…5 TCM in the treatment of bone cancer pain is used in China before the TCM-rich component is isolated for anti-cancer therapy. 7 In another pharmacological activity, FN can prevent cancers through regulating oestrogen-dependent signalling pathway, including breast, prostate and colon cancers. 7 In another pharmacological activity, FN can prevent cancers through regulating oestrogen-dependent signalling pathway, including breast, prostate and colon cancers.…”

Section: Introductionmentioning

confidence: 99%

“…6 Formononetin (FN), a bioactive chemical from Astragalus root, is found to play many benefits, such as anti-neuropathy, anti-hyperlipaemia and anti-cardiopathy effects. 7 In another pharmacological activity, FN can prevent cancers through regulating oestrogen-dependent signalling pathway, including breast, prostate and colon cancers. 8 Additionally, our previous data showed that FN promotes cell apoptosis of human bone cancer in vitro and in vivo through the molecular mechanism of regulating intracellular Bcl-2, Bax and MiR-375 expressions.…”

Section: Introductionmentioning

confidence: 99%

Anti‐cancer targets of formononetin and molecular mechanisms in osteosarcoma: Findings of bioinformatic and experimental assays

Zhao³

et al. 2019

J Cellular Molecular Medi

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In current study, a bioinformatic‐based network pharmacology was used to identify the osteosarcoma ( OGS )‐pathological targets and formononetin ( FN )‐treated targets before the main core predictive biotargets were screened. In addition, all core targets were selected through a number of bioinformatic databases, followed by identification of predominant biological processes and signalling pathways of FN anti‐ OGS . Further, top three core targets of FN anti‐ OGS were determined as oestrogen receptor 1 ( ESR 1), tumour protein p53 ( TP 53), receptor tyrosine‐protein kinase erbB‐2 ( ERBB 2) respectively. In clinical biochemical data, the plasma samples of OGS showed the increased trends of alkaline phosphatase, triglyceride, blood glucose, lactate dehydrogenase, high‐sensitive C‐reactive protein and some immune cell counts when referenced to medical criteria. In clinicopathological examination, histological OGS sections resulted in increased positive cell counts of neoplastic ESR 1, TP 53, ERBB 2. To further validate these corn proteins in experimental study in vivo, FN ‐treated tumour‐bearing nude mice showed intracellular reductions of ESR 1, TP 53, ERBB 2 positive expressions, accompanied with visibly reduced tumour weights. Collectively, our bioinformatic and experimental findings disclosed main core targets, biological processes and signalling pathways of FN anti‐ OGS . Interestingly, the top core targets were representatively validated following FN treatment in vivo. Therefore, we reasoned that these predictive targets might be the potential biomarkers for screening and treating osteosarcoma.

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Research Progress on the Antifibrotic Activity of Traditional Chinese Medicine Polysaccharides

Zhao,

Li,

Cai

et al. 2024

Chemistry & Biodiversity

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Fibrosis is a pathological process characterized by excessive extracellular matrix (ECM) deposition and proliferation fibrous tissue, a condition associated with various chronic diseases, such as liver cirrhosis, inflammation of the lungs, and myocarditis. Clinical treatment options for fibrotic diseases are currently limited and have poor efficacy. However, recent studies have increasingly demonstrated that polysaccharides exhibit significant antifibrotic activity by modulating cell proliferation and migration, inhibiting inflammation and oxidative stress associated fibrosis, and regulating gut microbiota. This review provides an overview of recent advances in polysaccharide research for antifibrosis and offers new perspectives on the treatment of fibrotic diseases.

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The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice

Cited by 60 publications

References 28 publications

Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease

Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease

Anti‐cancer targets of formononetin and molecular mechanisms in osteosarcoma: Findings of bioinformatic and experimental assays

Research Progress on the Antifibrotic Activity of Traditional Chinese Medicine Polysaccharides

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