The protective effect of <i>Hypericum connatum</i> on stress-induced escape deficit in rat is related to its flavonoid content

Scheggi, Simona; Marandino, Aurelio; Monte, Donato Del; Martino, Laura De; Pelliccia, Teresa; Fusco, María del Rosario; Petenatti, Elisa M.; Gambarana, Carla; Feo, Vincenzo De

doi:10.3109/13880209.2015.1127979

Cited by 16 publications

(10 citation statements)

References 40 publications

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“…Several studies also demonstrated that various SJW extracts could reduce stress-induced behavioural deficits in the learned helplessness test (Bhattacharya, Chakrabarti, & Chatterjee, 1998;Chatterjee et al, 1998;Gambarana et al, 1999;Scheggi et al, 2016). The effect on cognition ability was tested in Barnes maze or Morris water maze.…”

Section: Behavioural Pharmacology Related To Antidepressant Effectsmentioning

confidence: 99%

Clinical relevance of St. John's wort drug interactions revisited

Nicolussi

Drewe

Butterweck

et al. 2020

British J Pharmacology

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The first clinically relevant reports of preparations of St. John's wort (SJW), a herbal medicine with anti‐depressant effects, interacting with other drugs, altering their bioavailability and efficacy, were published about 20 years ago. In 2000, a pharmacokinetic interaction between SJW and cyclosporine caused acute rejection in two heart transplant patients. Since then, subsequent research has shown that SJW altered the pharmacokinetics of drugs such as digoxin, tacrolimus, indinavir, warfarin, alprazolam, simvastatin, or oral contraceptives. These interactions were caused by pregnane‐X‐receptor (PXR) activation. Preparations of SJW are potent activators of PXR and hence inducers of cytochrome P450 enzymes (most importantly CYP3A4) and P‐glycoprotein. The degree of CYP3A4 induction correlates significantly with the hyperforin content in the preparation. Twenty years after the first occurrence of clinically relevant pharmacokinetic drug interactions with SJW, this review revisits the current knowledge of the mechanisms of action and on how pharmacokinetic drug interactions with SJW could be avoided. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Behavioural Pharmacology Related To Antidepressant Effectsmentioning

confidence: 99%

Clinical relevance of St. John's wort drug interactions revisited

Nicolussi

Drewe

Butterweck

et al. 2020

British J Pharmacology

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“…olympicum , and H . adenotrichum , among others [ 3 – 5 ], mainly studying their biological activity. Phenolic compounds usually account for many of the bio(chemical) properties of plant extracts, so exhaustive investigation of the phytochemical composition of the plant extracts is mandatory.…”

Section: Introductionmentioning

confidence: 99%

Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations

et al. 2018

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The genus Hypericum is one of the most popular genera in both traditional medicine and scientific platform. This study is designed to provide conceptual insights on the biological potential and chemical characterization of H. salsugineum, which is endemic to Turkey. The qualitative and quantitative phenolic content of the extracts was characterized by HPLC-ESI-MSn. Biological efficiency was investigated by enzyme inhibitory assays (cholinesterases, tyrosinase, amylase, and glucosidase) and anti-cancer efficacy tests (anti-proliferative activities with the iCELLigence technology, colony formation and wound healing scratch assays). Phenolic acids (3-O-caffeoylquinic, 5-O-caffeoylquinic, and 4-O-caffeoylquinic acids) were the predominant group in the studied extracts, although several flavonoids were also detected and quantified. The extracts exhibited good inhibitory effects on tyrosinase and glucosidase, while they had weak ability against cholinesterases and amylase. Computational studies were also performed to explain the interactions between the major phenolics and these enzymes. The extracts displayed significant anti-cancer effects on breast carcinoma cell lines. Our findings suggest that Hypericum salsugineum could be valued as a potential source of biologically-active compounds for designing novel products.

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“…The authors concluded that quercetin may be considered as a partially useful supplement for the treatment of diabetic depression, and the antidepressant-like properties of quercetin seem to be independent of the HPA axis. Furthermore, Scheggi et al [ 106 ] reported antidepressant activity of Hypericum perforatum L. (Hypericaceae) related to the flavonoid components of this species including quercetin. Also, Rinwa and Kumar [ 107 ] have shown that quercetin suppresses the microglial neuroinflammatory response and induces the antidepressant-like effect in olfactory bulbectomized rats.…”

Section: Resultsmentioning

confidence: 99%

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Hrițcu

Ionita

Postu

et al. 2017

Oxidative Medicine and Cellular Longevity

106

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Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity, and affects various physiological and biochemical functions in the body. Studies show the clinical potential of antioxidant flavonoids in treating depressive disorders and strongly suggest that these natural products are interesting prototype compounds in the study of new antidepressant drugs. So, this review will summarize the chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity. The mechanisms of action of these compounds are also discussed, including their actions on oxidative stress relating to depression.

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The protective effect of Hypericum connatum on stress-induced escape deficit in rat is related to its flavonoid content

Cited by 16 publications

References 40 publications

Clinical relevance of St. John's wort drug interactions revisited

Clinical relevance of St. John's wort drug interactions revisited

Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

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