The protective effect of <i>Zataria multiflora Boiss</i> essential oil on CCl<sub>4</sub> induced liver fibrosis in rats

Barghi, Maryam; Ashrafi, Mahboobeh; Aminlari, Mahmoud; Namazi, Fateme; Nazifi, Saeed

doi:10.1080/01480545.2019.1571502

Cited by 8 publications

(2 citation statements)

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“…Although the mechanism by which CCL 4 causes damage in tissues is unclear, studies have reported that it leads to oxidative stress by increasing free oxygen radical production. 7,9,20 Yousefi-Manesh et al reported that CCL 4 increased MDA and reduced SOD levels in hepatic tissue. 9 In contrast, Cosgun et al reported that CCL 4 increased both MDA and SOD levels in small intestine tissue.…”

Section: Discussionmentioning

confidence: 99%

“…[17][18][19] Animal studies have revealed CCL 4induced alterations in animal models of the liver, kidney, lung, and spleen. 4,9,13,[20][21][22][23] Such studies have shown that CCL 4 causes oxidative stress in a variety of organs and exhibits a broad range of toxicity. 12,13,17,23 Its toxic effects are due to its metabolites trichloromethyl free radical and trichloromethyl peroxyl radical, and also trigger the release of tumor necrosis factor-alpha (TNF-a) and interleukin-1 beta.…”

Section: Introductionmentioning

confidence: 99%

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Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis

et al. 2019

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Carbon tetrachloride (CCL4) is often employed in the production of chlorofluorocarbons, petroleum refining, oil and rubber processing, and laboratory applications. Oral, subcutaneous, and inhalation exposure to CCL4 in animal studies have been shown to be capable of leading to various types of cancer (benign and malignant, liver, breast, and adrenal gland tumors). The present study also evaluated the protective role of infliximab (INF) against the deleterious effects of CCL4 on the intestinal system. Twenty-four male Sprague-Dawley rats were randomly assigned into three groups, control ( n = 8), CCL4 ( n = 8), and CCL4 + INF ( n = 8). The control group received 1 mL isotonic saline solution only via intraperitoneal (i.p.) injection. The CCL4 group received a single i.p. dose of 2 mL/kg CCL4. The CCL4 + INF group received a single i.p. dose of 7 mg/kg INF followed 24 h later by a single dose of 2 mL/kg CCL4. All rats were euthanized 2 days following drug administration. CCL4 group samples also exhibited diffuse loss of enterocytes, vascular congestion, neutrophil infiltration, an extension of the subepithelial space and significant epithelial lifting along the length of the villi with a few denuded villous tips. In addition, CCL4 treatment increased intestinal malondialdehyde (MDA) level and caspase-3 positivity. On the other hand, INF decreased MDA levels, caspase-3 positivity, and loss of villous. Our findings suggest that CCL4 appears to exert a highly deleterious effect on the intestinal mucosa. On the other hand, INF is effective in preventing this CCL4-induced intestinal injury by reducing oxidative stress and apoptosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis

et al. 2019

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Therapeutic effects of Chlorella vulgaris on carbon tetrachloride induced liver fibrosis by targeting Hippo signaling pathway and AMPK/FOXO1 axis

et al. 2020

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Natural essential oils efficacious in internal organs fibrosis treatment: Mechanisms of action and application perspectives

Long

et al. 2022

Pharmacological Research

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The protective effect of Zataria multiflora Boiss essential oil on CCl₄ induced liver fibrosis in rats

Cited by 8 publications

References 60 publications

Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis

Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis

Therapeutic effects of Chlorella vulgaris on carbon tetrachloride induced liver fibrosis by targeting Hippo signaling pathway and AMPK/FOXO1 axis

Natural essential oils efficacious in internal organs fibrosis treatment: Mechanisms of action and application perspectives

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The protective effect of Zataria multiflora Boiss essential oil on CCl4 induced liver fibrosis in rats

Cited by 8 publications

References 60 publications

Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis

Effects of infliximab against carbon tetrachloride-induced intestinal injury via lipid peroxidation and apoptosis

Therapeutic effects of Chlorella vulgaris on carbon tetrachloride induced liver fibrosis by targeting Hippo signaling pathway and AMPK/FOXO1 axis

Natural essential oils efficacious in internal organs fibrosis treatment: Mechanisms of action and application perspectives

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The protective effect of Zataria multiflora Boiss essential oil on CCl₄ induced liver fibrosis in rats