The Protective Effect of Inhalation of Oxygen at Two Atmospheres Absolute Pressure in Acute Coronary Arterial Occlusion

Smith, Godfrey L.; Lawson, D. D.

doi:10.1097/00132586-196402000-00009

Cited by 12 publications

(13 citation statements)

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“…The same authors 2 in 1962 substantiated their conclusions by similar results obtained in additional experiments and reported favorable impressions from their initial clinical trial with this form of treatment.…”

supporting

confidence: 58%

Reduction by Hyperbaric Oxygenation of the Mortality from Ventricular Fibrillation Following Coronary Artery Ligation

Chardack

Gage

Federico

et al. 1964

Circulation Research

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The effect of the inhalation of hyperbaric oxygen on the incidence of ventricular fibrillation following ligation of the circumflex coronary artery was studied in 151 dogs weighing 17 kg or more. Fifty-two per cent of the animals in the control group (room air, 1 atm abs) survived the challenge of this ligation. Survival increased to 60.4, 70, and 77.8% in the groups given 100% oxygen at an ambient pressure of 1, 2, and 4 atm abs, respectively. The orderly progression in the proportion of survivals is impressive but only approaches statistical significance. The results of these experiments are less dramatic than those previously reported by others. They do point out the need for cautious clinical trial in rigidly controlled series.

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supporting

confidence: 58%

Reduction by Hyperbaric Oxygenation of the Mortality from Ventricular Fibrillation Following Coronary Artery Ligation

Chardack

Gage

Federico

et al. 1964

Circulation Research

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“…Studies using HBO in the animal model of compartment syndromes demonstrate a preservation of skeletal muscle and adenosine triphosphatase activity [5,6]. In animal stud-ies, HBO also reduces the ischemic effects of coronary artery occlusion [7][8][9][10]. However, prior human trials detected little substantial benefit from HBO without concomitant thrombolysis [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen and Thrombolysis in Myocardial Infarction: The ‘HOT MI’ Randomized Multicenter Study

Stavitsky

Shandling²,

Ellestad³

et al. 1998

Cardiology

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In a previous pilot study, we demonstrated that adjunctive treatment with hyperbaric oxygen (HBO) appears to be feasible and safe in patients with acute myocardial infarction (AMI) and may result in an attenuated rise in creatine phosphokinase (CPK), more rapid resolution of pain and ST changes. This randomized multicenter trial was organized to further assess the safety and feasibility of this treatment in human subjects. Patients with an AMI treated with recombinant tissue plasminogen activator (rTPA) or streptokinase (STK), were randomized to treatment with HBO combined with either rTPA or STK, or rTPA or STK alone. An analysis included 112 patients, 66 of whom had inferior AMIs (p = NS). The remainder of the patients had anterior AMIs. The mean CPK at 12 and 24 h was reduced in the HBO patients by approximately 7.5% (p = NS). Time to pain relief was shorter in the HBO group. There were 2 deaths in the control and 1 in those treated with HBO. The left ventricle ejection fraction (LVEF) on discharge was 51.7% in the HBO group as compared to 48.4% in the controls (p = NS). The LVEF of the controls was 43.4 as compared to 47.6 for those treated, approximately 10% better (no significant difference). Treatment with HBO in combination with thrombolysis appears to be feasible and safe for patients with AMI and may result in an attenuated CPK rise, more rapid resolution of pain and improved ejection fractions. More studies are needed to assess the benefits of this treatment.

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“…These results on the duration of the arrhythmia in the isolated rabbit heart are in general agreement with those of Burn & Hukovic (1967) and suggest that a boundary or trigger zone between normal and anoxic myocardium which occurs with coronary occlusion (Harris, 1948) is not essential for sensitization of the ventricles to electrically-induced fibrillation. However, it would appear that this boundary zone may be of importance in order that ventricular fibrillation may occur spontaneously because the incidence of its occurrence is markedly reduced when the degree of anoxia of the infarcted area is reduced by the administration of hyperbaric oxygen (Smith & Lawson, 1962;Chardack et al, 1964) and spontaneously arising ventricular fibrillation was not seen during 02 lack in the rabbit isolated perfused heart. Such a boundary zone between normal and altered myocardium not only occurs in cardiac infarction but also where cold, drugs etc., are applied to a localized area of the myocardium.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Anoxia on the Ventricular Fibrillation Threshold in the Rabbit Isolated Heart

Murnaghan

1975

British J Pharmacology

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The ventricular fibrillation threshold (VFT) was measured in the isolated heart of the rabbit perfused via the aorta with McEwen's solution at 37° C by applying a single 10 ms pulse of current during the vulnerable period of late systole. The arrhythmia induced was either fibrillation or a rapid tachycardia. Gassing the McEwen's solution with 5% CO2 in N2 (anoxia) instead of with carbogen caused a negative inotropic and chronotropic effect and significantly lowered the VFT. Although anoxia releases noradrenaline from the heart the effect of anoxia on the VFT was not prevented by β‐adrenoceptor blockade with propranolol or pindolol or by previous treatment with reserpine. Perfusion with adenosine (5 μM) which is released from the heart muscle by anoxia, or with dipyridamole (10 μM) which protects the adenosine from binding or destruction by the tissues, or with both combined failed to alter the VFT significantly. Furthermore neither adenosine nor dipyridamole significantly altered the effect of anoxia on the VFT. Anoxia, adenosine and dipyridamole significantly increased the duration of the induced arrhythmia when compared with that of the controls. Anoxia and adenosine significantly shortened the vulnerable time, i.e. the minimal time after the R‐wave of the ECG at which the pulse had to be applied to induce the arrhythmia. Perfusion with the McEwen's solution gassed with 5% CO2 in air (hypoxia) significantly lowered the VFT but the effect was not as great as with anoxia. Isoprenaline when infused lowered the VFT but this effect was not potentiated by hypoxia. The results indicate that (a) anoxia lowers the VFT in the perfused isolated heart of the rabbit and that this effect is not due to adenosine or noradrenaline released by the anoxia and (b) hypoxia does not sensitize the heart to the arrhythmic effect of isoprenaline.

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The Protective Effect of Inhalation of Oxygen at Two Atmospheres Absolute Pressure in Acute Coronary Arterial Occlusion

Cited by 12 publications

References 0 publications

Reduction by Hyperbaric Oxygenation of the Mortality from Ventricular Fibrillation Following Coronary Artery Ligation

Reduction by Hyperbaric Oxygenation of the Mortality from Ventricular Fibrillation Following Coronary Artery Ligation

Hyperbaric Oxygen and Thrombolysis in Myocardial Infarction: The ‘HOT MI’ Randomized Multicenter Study

The Effect of Anoxia on the Ventricular Fibrillation Threshold in the Rabbit Isolated Heart

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