The Protective Effect of Lasia spinosa (Linn.) Dissipates Chemical-Induced Cardiotoxicity in an Animal Model

Abstract

Lasia spinosa (L.) Thwaites is a medicinal plant of enormous traditional use with insu cient scienti c evidence. This research screened the antioxidative effect of L. spinosa extracts by measuring the total phenolic content, total avonoid content, DPPH free radical scavenging activity, ABTS scavenging activity, Iron chelating activity, and Ferric reducing power followed by an evaluation of in-vivo cardioprotective effect in doxorubicin-induced Wistar albino rats. Phytochemical characterization was made by Gas-Chromatography Mass Spectroscopic analysis. L. spinosa showed an excellent antioxidative effect while Methanol leaf extract (LSM) was found to be more potent than Ethyl acetate leaf extract (LSE) in scavenging the free radicals. Intraperitoneal injection of doxorubicin caused a signi cant (P < 0.001) increase in lactate dehydrogenase (LDH), creatine kinase (CK-MB), C-reactive protein(CRP), and Cardiac troponin I. Pretreatment with orally administrated (LSM100 and LSM200 mg/kg b.w) daily for 10 days showed a decrease in the cardiac markers, lipid pro les, especially triglyceride (TG), total cholesterol (TC), Low-density lipoprotein (LDL), an increase of High-density lipoprotein (HDL) compared to the disease control group. LSM200 was found to signi cantly (P < 0.05) decrease the levels of CK-MB and LDH. It also restored TC, TG, and LDL levels compared to the doxorubicin-induced cardiac control group. The protective role of LSM was further con rmed by histopathological examination. This study thus demonstrates that L. spinosa methanol extract could be approached as an alternative supplement for cardiotoxicity, especially in the chemical-induced toxicity of cardiac tissues.

Lasia spinosa (L.) thw. attenuates chemically induced behavioral disorders in experimental and computational models

“…The stems and leaves of L. spinosa possessed significant antioxidant potentials and used as prospective functional foods [ 30 ]. It has been demonstrated that L. spinosa exhibits cardioprotective properties against doxorubicin-induced cardiotoxicity by normalizing specific biochemical markers, notably creatinine kinase, lactate dehydrogenase, and troponin I [ 31 ]. Although the herb has many therapeutic benefits for physical ailments, its therapeutic impact on neurological disorders has yet to be empirically assessed.…”