The protective effect of Lonicera japonica polysaccharide on mice  with depression by inhibiting NLRP3 inflammasome

Liu, Ping; Bai, Xinyu; Zhang, Tao; Zhou, Limei; Li, Jing; Zhang, Lan

doi:10.21037/atm.2019.12.64

Cited by 31 publications

(15 citation statements)

References 26 publications

(26 reference statements)

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“…IGF1, acts as a ligand for IGF1R, activated the PI3K-AKT [59] and Ras-MAPK [6] pathways. PIK3R1 and AKT1 were the key proteins of the PI3K-AKT [59] pathways which regulate apoptosis and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke

Wang

Chen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Panax notoginseng saponins (PNS) have been deemed effective herb compounds for treating ischaemic stroke (IS) and improving the quality of life of IS patients. This study aimed to investigate the underlying mechanisms of PNS in the treatment of IS based on network pharmacology. Methods. PNS were identified from the Traditional Chinese Medicine System Pharmacology (TCMSP) database, and their possible targets were predicted using the PharmMapper database. IS-related targets were identified from the GeneCards database, OMIM database, and DisGeNET database. A herb-compound-target-disease network was constructed using Cytoscape, and protein-protein interaction (PPI) networks were established with STRING. GO enrichment and KEGG pathway analysis were performed using DAVID. The binding of the compounds and key targets was validated by molecular docking studies using AutoDock Vina. The neuroprotective effect of TFCJ was substantiated in terms of oxidative stress (superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde) and the levels of IGF1/PI3K/Akt pathway proteins. Results. A total of 375 PNS targets and 5111 IS-related targets were identified. Among these targets, 241 were common to PNS, and IS network analysis showed that MAPK1, AKT1, PIK3R1, SRC, MAPK8, EGFR, IGF1, HRAS, RHOA, and HSP90AA1 are key targets of PNS against IS. Furthermore, GO and KEGG enrichment analysis indicated that PNS probably exert therapeutic effects against IS by regulating many pathways, such as the Ras, oestrogen, FoxO, prolactin, Rap1, PI3K-Akt, insulin, PPAR, and thyroid hormone signalling pathways. Molecular docking studies further corroborated the experimental results.The network pharmacology results were further verified by molecular docking and in vivo experiments. Conclusions. The ameliorative effects of PNS against IS were predicted to be associated with the regulation of the IGF1-PI3K-Akt signalling pathway. Ginsenoside Re and ginsenoside Rb1 may play an important role in the treatment of IS.

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Section: Discussionmentioning

confidence: 99%

“…At present, there are no specific drugs for the clinical treatment of IS. Most of the drugs used for treatment are drugs that protect against free radical damage, thrombolytic drugs, antiplatelet aggregation drugs, anti-inflammatory drugs, and anticoagulants [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke

Wang

Chen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Meanwhile, animal models displayed anxiety and depression-like behavior and memory loss symptoms. Suppressing the activation of the NLRP3 inflammasome exerted neuroprotective effects and improved the aforementioned neurological symptoms ( Lu et al, 2014 ; Zhang et al, 2014 ; Xu et al, 2016 ; Liu et al, 2019 ; Fu et al, 2020 ; Li et al, 2020 ). In addition, several recent studies have shown that the NLPR3 inflammasome is involved in the pathogenesis of neuropathic pain, and inhibition of NLPR3 inflammasome can effectively alleviate nociceptive hypersensitivity ( Jia et al, 2017 ; Zhang et al, 2017 ; Grace et al, 2018 ; Khan et al, 2018 ; Pan et al, 2018 ; Chen et al, 2019a , 2019b ).…”

Section: Discussionmentioning

confidence: 99%

Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State by Suppressing the Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury

Liu

Chen

et al. 2020

International Journal of Neuropsychopharmacology

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Background Neuropathic pain (NP) is a multifaceted and ubiquitous disease across the globe. Mood disorders, such as anxiety and depression, are frequently observed in patients suffering from NP. Both NP and comorbid mood disorders seriously impacts the quality of life. Accumulated evidence shows that activation of the NOD-like receptor protein 3 (NLRP3) inflammasome is involved in the neuroinflammatory pathogenesis of NP, anxiety, and depression. However, the role of the NLRP3 inflammasome in the pathological process of anxiety and depression under the NP state has not been fully described. Albiflorin (AF), a monoterpene glycoside, may be a potential regulator of the NLRP3 inflammasome, but it is not clear whether AF relates to NLRP3 inflammasome activation. Methods We used a systematic pharmacological method to confirm whether the activation of the NLRP3 inflammasome in the hippocampus was involved in the development of NP associated with mood disorders, and whether AF could be an effective treatment for these symptoms. Results The NLRP3 inflammasome contributed to the NP and comorbid anxiety and depression-like behaviors induced by chronic constriction injury of the sciatic nerve, and that AF may relieve these symptoms via inhibition of the NLRP3 inflammasome activity. Moreover, AF enhanced the translocation of the nuclear factor erythroid 2-related factor 2 (Nrf2) into the nucleus and suppressed NF-κB activity in the hippocampus. Conclusions AF, as a potential therapeutic agent, might greatly improve the overall symptoms of NP.

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“…Previous studies have found that polysaccharides extracted from plants can relieve oxidative stress through exerting their antioxidation potentials ( Surin et al, 2018 ; Zhou et al, 2020 ). Polysaccharide is one of the main active ingredients of L. japonica , which have been isolated and identified in previous studies ( Zhou et al, 2018a , 2020 ; Liu et al, 2019 ; Zhang T. et al, 2020 ). In vitro study showed that polysaccharide extracts from L. japonica exhibited obvious DPPH-scavenging activity, ABTS + -scavenging activity, hydroxyl radical-scavenging activity, superoxide radical-scavenging activity, and excellent inhibitory activity on erythrocyte hemolysis induced by H 2 O 2 ( Zhang T. et al, 2020 ).…”

Section: Lonicera Japonica (Extracts) and Intestinal Antioxidantmentioning

confidence: 99%

Potential Application of Lonicera japonica Extracts in Animal Production: From the Perspective of Intestinal Health

et al. 2021

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Lonicera japonica (L. japonica) extract is rich in active substances, such as phenolic acids, essential oils, flavones, saponins, and iridoids, which have a broad spectrum of antioxidant, anti-inflammatory, and anti-microbial effect. Previous studies have demonstrated that L. japonica has a good regulatory effect on animal intestinal health, which can be used as a potential antibiotic substitute product. However, previous studies about intestinal health regulation mainly focus on experimental animals or cells, like mice, rats, HMC-1 Cells, and RAW 264.7 cells. In this review, the intestinal health benefits including antioxidant, anti-inflammatory, and antimicrobial activity, and its potential application in animal production were summarized. Through this review, we can see that the effects and mechanism of L. japonica extract on intestinal health regulation of farm and aquatic animals are still rare and unclear. Further studies could focus on the regulatory mechanism of L. japonica extract on intestinal health especially the protective effects of L. japonica extract on oxidative injury, inflammation, and regulation of intestinal flora in farm animals and aquatic animals, thereby providing references for the rational utilization and application of L. japonica and its extracts in animal production.

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The protective effect of Lonicera japonica polysaccharide on mice with depression by inhibiting NLRP3 inflammasome

Cited by 31 publications

References 26 publications

A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke

A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke

Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State by Suppressing the Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury

Potential Application of Lonicera japonica Extracts in Animal Production: From the Perspective of Intestinal Health

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