The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

Koyuncu, İsmail; Koçyiğit, Abdürrahim; Gönel, Ataman; Arslan, Erkan; Durgun, Mustafa

doi:10.1155/2017/9478958

Cited by 62 publications

(55 citation statements)

References 56 publications

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“…In addition, no biochemical toxicity was observed in treated rats, as shown in Table , thus providing evidence that Cℓ‐HIN is not hepato‐ or nephrotoxic. These results are in agreement with Koyuncu et al which showed that oxime treatment is non‐toxic to rodents . Collectively, these data suggest that a single dose of 300 mg/kg of Cℓ‐HIN is safe in rodents, which is in agreement with studies that reported similar LD 50 values for other classical oximes (pralidoxime and obidoxime)…”

Section: Discussionsupporting

confidence: 92%

“…These results are in agreement with Koyuncu et al which showed that oxime treatment is non-toxic to rodents. 51 Collectively, these data suggest that a single dose of 300 mg/kg of Cℓ-HIN is safe in rodents, which is in agreement with studies that reported similar LD 50 values for other classical oximes (pralidoxime and obidoxime). 52 Isatin is an endogenous compound present in plants and human beings.…”

Section: Discussionsupporting

confidence: 89%

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Pre‐clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion‐induced toxicity

Savall

Fidélis

Gutierrez

et al. 2019

Basic Clin Pharma Tox

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The inhibition of acetylcholinesterase (AChE) is a common outcome caused by organophosphorus (OPs) intoxication. Although inconsistent, the standard treatment consists of a muscarinic receptor antagonist (atropine) and AChE‐reactivating molecules such as oximes. This study proposes to test unpublished compounds which contain the moieties of isatin and/or oxime have protective effects against the toxicity induced by malathion in two animal models: Artemia salina and Rattus norvegicus (Wistar rats). The lethality was assessed in A salina, and the calculated LD50 to (3Z)‐5‐chloro‐3‐(hydroxyimino) indolin‐2‐one oxime (Cℓ‐HIN) and 2‐(5‐chloro‐2‐oxoindolin‐3‐ylidene)‐hydrazinecarbothioamide (Cℓ‐OXHS) was higher than 1000 µM while to 3‐(phenylhydrazono) butan‐2‐one oxime (PHBO) was 38 µM. Our screening showed that Cℓ‐HIN seems to be the most promising molecule, with low toxicity to A salina, protection against mortality (with or without atropine) and AChE inhibition induced by malathion. Similarly, the oral administration of 300 mg/kg of Cℓ‐HIN induced low or no toxicity in rats. The plasma butyrylcholinesterase (BChE) and cortical AChE activities were reactivated by Cℓ‐HIN (50 mg/kg, p.o.) in rats exposed to malathion (250 mg/kg, i.p). No difference was observed in paraoxonase‐1 (PON‐1) activity among groups treated. In conclusion, Cℓ‐HIN restored the cholinesterase activities inhibited by malathion in A salina and rats with low toxicity in both. Thus, the data provide evidence that Cℓ‐HIN, a compound that combines isatin and oxime functional groups, is safe and has important properties to reactivate the cholinesterases inhibited by malathion. In addition, we demonstrate the importance of a preliminary assessment in an alternative model in order to reduce the use of mammalians in drug discovery.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Pre‐clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion‐induced toxicity

Savall

Fidélis

Gutierrez

et al. 2019

Basic Clin Pharma Tox

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“…PmEO100CP and BCP pre-treated rats significantly restored protein carbonyl content in the liver similar to the role of natural product on protein carbonylation previously shown by Mohamed et al (2013). 8-OHdG is the most significant indicator of DNA damage (Koyuncu et al 2017). According to Cadet (2014), hydrogen from nucleic acids being eliminated by hydroxyl radicals or reacted with double bonds may lead to production of 8-OHdG.…”

Section: Discussionsupporting

confidence: 79%

“…Our results demonstrated that 8-OHdG is significantly increased in cisplatin-treated rats as compared to the control group. Previous studies showed that DNA damage was significantly inhibited by pre-treatment with natural compounds (Ince et al 2014;Koyuncu et al 2017). PmEO100CP and BCP likely used its antioxidant activity and decreased ROS-mediated 8-OHdG production.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Polygonum minus Essential Oil on Cisplatin-Induced Hepatotoxicity in Sprague Dawley Rats

Rashid

Hussan

Hamid³

et al. 2019

JSM

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Cisplatin is a chemotherapeutic agent widely used in treating various types of cancer. However, its usage is restricted due to the adverse hepatoxicity, as seen in approximately 36% of cancer patients receiving cisplatin treatment. Polygonum minus essential oil has high antioxidant capacity, and is enriched with terpenoids and phenolic compounds. The objective of this study was to investigate effects of P. minus essential oil (PmEO) supplementation on cisplatininduced hepatotoxicity in rats. Male rats were divided into seven different groups, namely: control (C), cisplatininduced (CP), positive control with β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg (PmEO100CP), PmEO 200 mg/kg (PmEO200CP), PmEO 400 mg/kg (PmEO400CP) and PmEO 400 mg/kg alone (PmEO400). PmEO and BCP was given orally for 14 days prior to a single dose cisplatin (10 mg/kg) injection on day 15 and rats were sacrificed on day 18. Liver enzymes, histology, ultrastructural morphology and oxidative stress markers such as glutathione, glutathione peroxidase, catalase, superoxide dismutase and malondialdehyde were assayed. Compared to controls, levels of transaminase enzymes, serum bilirubin and oxidative stress were all increased in CP, PmEO200CP and PmEO400CP groups. However, only PmEO100CP and BCP groups reduced these increases in level of transaminase enzymes and oxidative stress compared to CP group. On both light microscopic and ultrastructural examination, CP and PmEO400CP groups showed hepatotoxicity, exhibited by cytoplasmic vacuolation, congested blood sinusoids and increased number of Kupffer cells. However, these changes were minimized in the PmEO100CP group. Therefore, we concluded that PmEO given at 100 mg/kg has preventive effect against cisplatin-induced hepatotoxicity in rats. ABSTRAKCisplatin adalah agen kemoterapi yang digunakan secara meluas untuk merawat pelbagai jenis kanser. Walau bagaimanapun, penggunaannya adalah sangat terhad disebabkan oleh berlakunya kehepatoksikan dalam kalangan kira-kira 36% pesakit kanser yang menerima rawatan cisplatin. Minyak pati Polygonum minus mempunyai keupayaan antioksidan yang tinggi dan diperkaya dengan terpenoid dan sebatian fenolik. Objektif kajian ini adalah untuk mengkaji kesan suplemen minyak pati P. minus (PmEO) ke atas cisplatin-aruhan kehepatoksikan di dalam tikus. Tikus jantan dibahagikan kepada tujuh kumpulan yang berbeza iaitu: kawalan (C), cisplatin-aruhan (CP), kawalan positif dengan β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg (PmEO100CP), PmEO 200 mg/kg (PmEO200CP), PmEO 400 mg/kg (PmEO400CP) dan PmEO 400 mg/kg sahaja (PmEO400). PmEO dan BCP diberikan secara oral selama 14 hari sebelum dos tunggal cisplatin (10 mg/kg) disuntik pada hari ke 15 dan tikus dikorbankan pada hari ke 18. Enzim hati, histologi, morfologi ultrastruktur dan penunjuk tekanan oksidatif seperti glutation, glutation peroksida, katalase, superoksida dismutase dan malondialdehid diasai. Berbanding dengan kawalan, tahap enzim transaminase, serum bilirubin dan tekanan oksidatif semuanya meningkat dalam kumpulan ...

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“…The drug, cisplatin (CP), used in the treatment of cancer, has toxic effects on liver, kidney and genes. In a study conducted on rats, it was shown that when rats were first treated with naringenin-oxime (NOX) which is produced from naringenin and then CP was injected to rats, NOX showed an antioxidant effect and reduced the oxidative stress and DNA damage (21).…”

Section: Anti-oxidant Activitymentioning

confidence: 99%

The Importance of Polyphenols as Functional Food in Health

Bayır¹,

Aksoy²,

Koçyiğit³

2019

Bezmialem Science

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Polyphenols which are produced by plants are very important functional foods in our nutrition. Because of their diverse chemical structures, they are subject to main classification among them. The main groups of polyphenols are; flavanoids, lignans, stilbenes and phenolic acids. At the present time, the health effects of them have been investigated in several in vivo and in vitro studies. In addition to their antioxidant effects, they are known to have a pro-oxidant character. Polyphenols have important effects in protecting the body against external factors and the cleansing of reactive oxygen species which occur as a consequence of some diseases. Furthermore, polyphenols have effects on protection from specific diseases and stop their progression with certain mechanisms. In this review, various effects of polyphenols including antioxidant, pro-oxidant, cytotoxic, anti-inflammatory, antihypertensive, anti-diabetic are discussed which obtained from in vitro, in vivo experimental animal and clinical investigations.

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The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

Cited by 62 publications

References 56 publications

Pre‐clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion‐induced toxicity

Pre‐clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion‐induced toxicity

Preventive Effects of Polygonum minus Essential Oil on Cisplatin-Induced Hepatotoxicity in Sprague Dawley Rats

The Importance of Polyphenols as Functional Food in Health

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