The Protective Effect of Omega-3 Against Thioacetamide Induced Lipid and Renal Dysfunction in Male Rats

Abstract

Background: Thioacetamide causes lipid and kidney dysfunction.Omega-3 unsaturated fatty acids prevent the progression of renal diseases. Objectives: This study aimed to assess the protective effects of omega-3 fish oil supplement on thioacetamide induced lipid and kidney dysfunction in male rats. Methods: In this experimental study, 42 male rats were divided into 6 groups of 7: control group sham group which received 0.4 mL olive oil as a solvent, Thioacetamide group receiving thioacetamide at a dose of 150 mg/kg once as intraperitoneal injection, Experimental groups of 1, 2 and 3 which received omega-3 fish oil supplement at the doses of 100, 200, 300 mg/kg orally for 3 months respectively and then they received thioacetamide at the dose of 150 mg/kg intraperitoneally for once. The levels of serum creatinine, BUN, total cholesterol, LDL, HDL, FBS, triglyceride, sodium and potassium were measured. The pathological changes of tissue samples of the kidneys were studied after hematoxylin-eosin staining. The data were analyzed by SPSS-18 software and using one way ANOVA and Tukey as post hoc test. Significant level was considered to be P < 0.05.

Synthesis of encapsulated fish oil using whey protein isolate to prevent the oxidative damage and cytotoxicity of titanium dioxide nanoparticles in rats

“…Additionally, the co-administration of EMFO and TiO 2 -NPs resulted in a marked improvement in creatinine, uric acid, and urea. These results were in accordance with other reports which indicated that ω-3 PUFAs protect the kidney against different toxicants ( Hassan and Gronert 2009 ; Moghadamnia et al., 2016 ). Moreover, EMFO also prevented the disturbances in lipid profile in animals that received TiO 2 -NPs.…”

Comparative study of the effect of Omega-3 and the nano-loaded Propylthiouracil on thyroxine-induced hyperthyroidism in male white rats

“…As for the improvement in the totals treated with Omega-3 compared to T1group, it is due to the content of omega-3 unsaturated fatty acids, which are known for their regulatory properties of various body functions, they are classified among the most important anti-inflammatory and powerful oxidants that work to remove free radicals directly or indirectly by activating antioxidants such as GSH, CAT and SOD [24], where (EPA) is one of the most important fatty acids forming Omega-3, which makes up 18% of it, so it affects the level of thyroid hormones in two main directions, the first is the regulation of nerve signalling pathways by affecting the membrane lipids of thyroid cells, which contributes to increasing the sensitivity of TSH receptors as a result of the improvement in phospholipids of cell membranes on the one hand and the rapid and direct modification of the gene transcription process, which effectively contributes to reducing the level of T 3 , T 4 hormones inside and outside the gland thyroiditis [25], and the improvement in the level of (TSH) is attributed to the effect of Omega-3 in enhancing the immune response and reducing inflammation, as it works to increase the stability of cell membranes and thus regulate the function of the immune system and prevent excessive inflammatory reactions, which is reflected positively on the regulation of the functions of the glands and the secretion of hormones, including the TSH hormone. Table (1).…”