2016
DOI: 10.1177/1076029616669785
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The Protective Effect of Poloxamer-188 on Platelet Functions

Abstract: The protective effects of MST-188 on ADP- and collagen-induced platelet aggregation may contribute to the preservation of platelet functionality upon storage in blood banks.

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Cited by 3 publications
(2 citation statements)
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“…P188 is safely and wildly used in the pharmaceutical industry as an excipient of formulations and an agent of drug delivery. Based on stable packaged drug, protein, or nucleotide delivery, affinity with cell membrane, and inducible cytoprotecting of P188, a recent study focuses on medicine industrial application including being sublingual permeation enhancers [ 31 ], stabilizer of anti-tumor drug [ 32 ], agent of promising blood cell viability [ 33 ], and transfection reagent of short nucleotide chains [ 34 ]. Furthermore, our study first suggests P188 not only has the potential as an adjuvant of subunit vaccines, but also as immune modulator and drug through affecting the p38MPAK pathway.…”
Section: Discussionmentioning
confidence: 99%
“…P188 is safely and wildly used in the pharmaceutical industry as an excipient of formulations and an agent of drug delivery. Based on stable packaged drug, protein, or nucleotide delivery, affinity with cell membrane, and inducible cytoprotecting of P188, a recent study focuses on medicine industrial application including being sublingual permeation enhancers [ 31 ], stabilizer of anti-tumor drug [ 32 ], agent of promising blood cell viability [ 33 ], and transfection reagent of short nucleotide chains [ 34 ]. Furthermore, our study first suggests P188 not only has the potential as an adjuvant of subunit vaccines, but also as immune modulator and drug through affecting the p38MPAK pathway.…”
Section: Discussionmentioning
confidence: 99%
“…The poloxamer family of block copolymers has been in wide use for drug delivery and other biomedical applications (78). P188 has been safely used in animals and humans, including advanced clinical trials for limiting vaso-occlusive crisis in sickle cell anemia 79, 80, 81. As reviewed in detail below, synthetic membrane stabilizers are amphiphilic long-chain macromolecular block copolymers that interact with and protect the muscle sarcolemma during stress (Central Illustration, Figure 2).…”
Section: The Cardiac Membrane As a Direct Therapeutic Target In Myocamentioning
confidence: 99%