The Protective Effect of Royal Jelly on Testicular 
Histomorphometry and Spermatogenesis
 in Heat-Stress Exposed Male Rats

Mahdivand, Noushin; Nejati, Vahid; Najafi, Gholamreza; Jalali, Ali Shalizar; Rahmani, Fatemeh

doi:10.29252/sjimu.26.6.69

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…PAS-stained sections showed almost regular basement membrane with few areas of thickening, similar to previous studies[ 44 ] which used RJ in different doses and found alleviation of testicular toxicity caused by aluminum chloride-induced oxidative stress, in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 89%

The Effect of Selenium Nanoparticles versus Royal Jelly against Cisplatin-Induced Testicular Toxicity in Adult Male Albino Rats

Mohammed

Eisa²,

El-Aziz³

et al. 2022

Journal of Microscopy and Ultrastructure

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Background and Aim: Cisplatin (Cis) is a highly effective chemotherapeutic agent. However, it produces severe testicular toxicity. It was reported that some antioxidants could overcome this toxicity. Selenium nanoparticles and royal jelly (RJ) were among these reported antioxidants. Therefore, this study was designed to compare these two antioxidants in protecting the testes against Cis-induced toxicity. Materials and Methods: This study was conducted on sixty healthy adult male albino rats (weight: 200–220 g) randomized into six groups, ten animals each. Group I (control), Group II (animals received intragastric Nano Selenium), Group III (animals received intragastric RJ), Group IV (animals received an IP injection of Cis 7 mg/kg), Group V (animals received intragastric Nano Selenium, and Cis injection), and Group VI (animals received intragastric RJ and Cis injection). After 10 days, the animals were sacrificed by cervical decapitation. The testes were weighted, and specimens from the left testis were processed for histological and immunohistochemical techniques, whereas specimens from the right testes were prepared for transmission electron microscopic examination. Results: Cis-treated animals had significantly reduced weight of their testes. Light microscopic examination revealed severe histopathological changes in the germinal epithelium and Leydig cells, confirmed with electron microscopic examination. There was a significant increase in the color area percentage of Caspase-3 immunostaining of the germinal epithelium and Leydig cells, compared to that of the control group. Group II and III were similar to control group. Both Groups V and VI revealed significant preservation compared to the Cis group. Conclusion: Selenium nanoparticles and RJ partially improved testis from Cis-induced toxicity, However, there was no significant difference between both groups.

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Section: Discussionsupporting

confidence: 89%

The Effect of Selenium Nanoparticles versus Royal Jelly against Cisplatin-Induced Testicular Toxicity in Adult Male Albino Rats

Mohammed

Eisa²,

El-Aziz³

et al. 2022

Journal of Microscopy and Ultrastructure

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“…It has been shown that RJ improved reproductive parameters in diabetic rats (Ghanbari, Nejati, & Khazaei, 2016; Ghanbari, Nejati, Najafi, Khazaei, & Babaei, 2015). Mahdivand et al reported that under testicular heat stress conditions, RJ could protect changes in testicular tissue and avoid decreases in sperm counts (Mahdivand, Nejati, Najafi, & Rahmani, 2019). RJ contains vitamins E and C (Nagai & Inoue, 2004).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of royal jelly on testicular torsion induced ischaemia reperfusion injury in rats

et al. 2020

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This study was performed to investigate the protective effects of royal jelly (RJ) on a testicular torsion-induced ischaemia/reperfusion (I/R) injury in adult rats. A total of 40 male Wistar rats were divided into four groups, including 10 rats in each group: Group 1 (sham), Group 2 (Control), group 3 (I/R rats treated with 100 mg/kg RJ for 50 days after torsion) and group 4(I/R rats treated with 20 mg/kg vitamin C for 50 days after torsion). Testicular torsion was created by rotating the right testes 720° a clockwise direction for 90 min. The levels of testosterone were measured by ELISA. Pathological evaluation, mean maturity and quality of the seminiferous tubules were used. Results showed that the testicular histopathology standards and testosterone levels changes were statistically significant in groups 3 and 4. The results obtained in this study may suggest that RJ like vitamin C had protective effects on a testicular ischaemia/reperfusion-induced injury in rats.

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“…RJ is made up of varied carbohydrates, proteins, lipids, vitamins, free amino acids, peptides, adenosine monophosphate N1-oxide, acetylcholine, fatty acids, as well as trace minerals and enzymes, and is released by the worker honeybees' hypopharyngeal and mandibular glands (Abd-Allah, 2012;Elnagar, 2010). RJ has a variety of biological activities including the cure of sexual impairment (Azad et al, 2018). Testosterone, estradiol, prolactin, progesterone, and insulin-like growth factor-1 have been found in RJ (Moghaddam et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The influence of various rates of royal jelly enriched extenders on frozen/thawed sperm quality and fertility in goats

Coskun Cetin,

Karaca

2023

J Hellenic Vet Med Soc

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The goal of this study was to detect the influence of royal jelly which has a strong antioxidant capacity supplementation in TRIS egg yolk and TRIS soybean lecithin extenders on quality and fertility. Sperm was collected from 5 Damascus bucks via an electro ejaculator during the breeding season. After dilution and cooling, the lowest motility and membrane integrity were detected in TEY-1RJ, in terms of abnormal spermatozoon rate, the TEY-1RJ group was the highest in cooled semen (P<0.05). After dilution and cooling, osmolality decreased significantly when the RJ ratio increased (P<0.05). After freezing-thawing, in both TEY and TSL extenders, the lowest sperm quality was detected in the 1% RJ groups. In terms of intact acrosome ratio, the highest value was recorded in the 0.50% RJ group in TEY and TSL diluents (P<0.05). Fertility assessments were conducted with 150 goats synchronized with intravaginal sponges and goats were inseminated transcervical. There was no difference between pregnancy rates between TEY and TSL-control and RJ groups (P>0.05). As a result, it was deduced that RJ additions to TEY and TSL extenders did not produce any alternative to freezing on sperm quality in Damascus goat semen except for the intact acrosome ratio and had no positive effect on fertility.

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The Protective Effect of Royal Jelly on Testicular Histomorphometry and Spermatogenesis in Heat-Stress Exposed Male Rats

Cited by 3 publications

References 2 publications

The Effect of Selenium Nanoparticles versus Royal Jelly against Cisplatin-Induced Testicular Toxicity in Adult Male Albino Rats

The Effect of Selenium Nanoparticles versus Royal Jelly against Cisplatin-Induced Testicular Toxicity in Adult Male Albino Rats

Protective effects of royal jelly on testicular torsion induced ischaemia reperfusion injury in rats

The influence of various rates of royal jelly enriched extenders on frozen/thawed sperm quality and fertility in goats

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