The protective effect of schisandra lignans on stress-evoked hepatic metastases of P815 tumor cells in restraint mice

Tang, Shu-Hong; He, Rong‐Rong; Huang, Ting; Wang, Congzhi; Cao, Yun‐Feng; Zhang, Yang; Kojima, Hiroshi

doi:10.1016/j.jep.2010.11.070

Cited by 22 publications

(12 citation statements)

References 27 publications

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“…Schisandra lignans extract was found to be significantly improving T lymphocyte proportions and increasing cytotoxic T lymphocyte activity of immunized spleen cells in stressed mice [33].…”

Section: Discussionmentioning

confidence: 90%

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Pozharitskaya¹,

Shikov²,

Косман³

et al. 2015

Synergy

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“…Schisandra lignans extract was found to be significantly improving T lymphocyte proportions and increasing cytotoxic T lymphocyte activity of immunized spleen cells in stressed mice [33].…”

Section: Discussionmentioning

confidence: 90%

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Pozharitskaya¹,

Shikov²,

Косман³

et al. 2015

Synergy

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“…G.A inhibited tumor growth and metastasis of B16BL6 cells by suppressing angiogenesis and adhesion of melanoma cells (Kim et al, 2012). Moreover, S. chinensis extracts containing G.A also protected against liver metastasis of P815 mastocytoma cells (Tang et al, 2011). In this study, we first demonstrated the inhibitory effects of G.A on the metastasis of CRC cells.…”

Section: Discussionmentioning

confidence: 99%

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells

et al. 2018

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Gomisin A (G.A) is a dietary lignan compound from Schisandra chinensis. In this study, the effect of G.A on the proliferation and metastasis of colorectal cancer (CRC) cells was investigated using several CRC cell lines and a lung metastasis mouse model. Both oral and intraperitoneal administration of G.A (50 mg/kg) inhibited lung metastasis of CT26 cells. Various concentrations of G.A were incubated with CRC cell lines and their viability was determined using a cell counting kit-8 assay. G.A significantly decreased the viability of various CRC cell lines, whereas it did not change the proliferation of normal colon cells. G.A induced G0/G1 phase arrest and apoptosis of CT26 and HT29 cells by regulating cyclin D1/cyclin-dependent kinase 4 (CDK4) expression and apoptotic proteins such as caspases and B-cell lymphoma-2 (Bcl-2) family proteins, respectively. G.A-induced apoptosis was mediated by AMPK/p38 activation in CRC cells. A non-cytotoxic concentration of G.A inhibited epithelial–mesenchymal transition of CRC cells by modulating E-cadherin and N-cadherin expression levels. Moreover, the migration and invasion of CRC cells were reduced by G.A treatment. Especially, G.A decreased matrix metalloproteinase (MMP)-2 and MMP-9 expressions and activities. G.A ameliorated lung metastasis of CRC cells by decreasing cell survival and metastatic abilities of CRC cells. Thus, G.A might be a potential novel therapeutic agent for metastatic CRC.

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“…A voucher specimen (2009WWZ0006) was deposited in Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China. SLE was extracted and analyzed by HPLC-MS as previously reported [13]. The compounds of lignans in SLE were identified as schizandrol A, schizandrol B, schisantherin A, deoxyschizandrin, schizandrin B and schisandrin C. Total lignans were quantitated by measuring against schizandrol A standard calibration curve.…”

Section: Methodsmentioning

confidence: 99%

“…We found that oral administration of SLE significantly reduced stress-evoked anxiety and hepatic metastases in restraint mice [3, 13]. Restraint or immobilization is a common animal model for inducing psychological stress, which results into many nonspecific physiological disorders in autonomic nervous system, endocrine system, and immune system and leads to organ dysfunctions [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

Cao

et al. 2012

Evidence-Based Complementary and Alternative Medicine

Self Cite

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The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.

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The protective effect of schisandra lignans on stress-evoked hepatic metastases of P815 tumor cells in restraint mice

Cited by 22 publications

References 27 publications

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells

Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

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