The Protective Effect of Taurine on the Biomembrane against Damage Produced by Oxygen Radicals.

Abstract

The effect of taurine in protecting biomembrane against oxygen radicals was investigated using canine erythrocytes. 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH), a water-soluble azo-compound, was used as the oxygen-radical generator. Taurine suppressed erythrocyte hemolysis more effectively than alpha-alanine, used for comparison. To clarify the relationship to the lipid peroxidation, the amount of lipid peroxide was measured using liposomes prepared with egg yolk lecithin. However, the peroxidation was not suppressed by taurine. When intact erythrocytes were subjected to hemolysis by hyposmotic solutions, taurine suppressed the osmotic hemolysis more effectively than alpha-alanine. These results suggest that taurine does not have an antioxidative effect like vitamin E, but interacts with the biomembrane, and helps to protect it against damage caused by AAPH.

Effects of Added Dietary Taurine on Erythrocyte Lipids and Oxidative Stress in Rabbits Fed a High Cholesterol Diet

“…33) Therefore, it has been suggested that these eŠects of taurine may be related to its inhibitor eŠect on lipid peroxidation and W or its stabilizator eŠect on membranes. [23][24][25]33) However, when normal rabbit erythrocytes were incubated with H2O2 in the presence of taurine, no changes were observed in the osmotic fragility test of erythrocytes (Fig. 1B) and MDA levels (Fig.…”

“…22) In addition, some investigators have reported that taurine has an ability to suppress erythrocyte hemolysis caused by oxidative damage in in vitro conditions. [23][24][25] However, there is no adequate report about the eŠects of taurine on erythrocyte hemolysis in in vivo conditions. Therefore, theˆrst aim of this study was to estimate the contribution of oxidative stress to hypercholesterolemia-induced hemolytic anemia in rabbits.…”

“…On the other hand, some investigators have reported that taurine can suppress erythrocyte hemolysis which was induced by using 2,2?-azobis (2-amidinopropan) 23) H2O2 24) and phenylhydrazine 25) under in vitro conditions. Taurine has also been reported to restore the depletion of erythrocyte membrane Na-K-ATPase activity after ozone exposure or cholesterol enrichment.…”

Islet transplantation and antioxidant management: A comprehensive review

“…Taurine (2-amino ethanesulfonic acid) an end-product of sulfur amino acid metabolism, is one of the most abundant free amino acids in the body. The membrane stabilizing, free radical scavenging, and osmoregulatory roles of taurine have been well documented [49,50] . In one study, taurine enhanced viability and reduced lipid peroxidation in cryopreserved islets.…”

Semi-synthesis of Twelve Known 20<i>Z</i>/<i>E</i> Pseudo-Ginsenosides and Their Comparative Study of Antioxidative Activity in Free Radical Induced Hemolysis of Rabbit Erythrocytes

“…Therefore, antioxidant therapy has become an attractive strategy. 3,4) Red blood cell membrane is consisted of abundant polyunsaturated fatty acids that are very susceptible to free radical mediated peroxidation.…”