The protective effects of cysteamine, putrescine, and the combination of cysteamineand putrescine on fibrosarcoma induced in mice with 3-methylcholanthrene

Doğan, Abdullah; Aksu, Pınar; Erdağ, Dinçer; Doğan, Ali Nazmi Can; Özcan, Kadir; Doğan, Ertan

doi:10.3906/vet-1510-49

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…In addition to them, putrescine, cadaverine, spermine, and spermidine were also found to induce apoptosis and inhibit cell proliferation. The high-dose putrescine was found to induce apoptosis and prevent the spread [81,82]. This putrescine effect pertains to increasing the nitric oxide synthesis, inhibiting the redox reactions and binding directly to the carcinogenic agents [82].…”

Section: Effect Of Biogenic Amines On Healthmentioning

confidence: 99%

Biochemical and Pharmacological Properties of Biogenic Amines

Erdağ¹,

Merhan²,

Yildiz³

2019

Biogenic Amines

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Biogenic amines are low molecular weight organic nitrogen compounds. They are formed by the decarboxylation of amino acids or by amination and transamination of aldehydes and ketones during normal metabolic processes in living cells and therefore are ubiquitous in animals, plants, microorganisms, and humans. In food and beverages, they are formed by the enzymes of raw materials or are generated by microbial decarboxylation of amino acids. The structure of a biogenic amine can be aromatic and heterocyclic amines (histamine, tryptamine, tyramine, phenylethylamine, and serotonin); aliphatic di-, tri-, and polyamines (putrescine, cadaverine, spermine, spermidine, and agmatine); and aliphatic volatile amines (ethylamine, methylamine, isopentylamine, and ethanolamine). Many of them possess a strong pharmacologic effect, and others are important as precursors of hormones and components of coenzymes. The biogenic amine intoxication leads to toxicological risks and health hazards that trigger psychoactive, vasoactive, and hypertensive effects resulting from consumption of high amounts of biogenic amines in foods. The toxicological effects of biogenic amines increase when the mono-and diaminoxidase enzymes are deficient or drugs that inhibit these enzymes (pain reliever, stress, and depression drugs) are used. In this chapter, biosynthesis of biogenic amines, their toxic effects as well as their physiological functions, and their effect on health will be described.

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Section: Effect Of Biogenic Amines On Healthmentioning

confidence: 99%

Biochemical and Pharmacological Properties of Biogenic Amines

Erdağ¹,

Merhan²,

Yildiz³

2019

Biogenic Amines

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Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma

Çoban

Değim

Yılmaz³

et al. 2019

Drug Development Research

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The main challenges in treating cancer using chemotherapeutics are insufficient dose at the target site and the development of drug resistance, while higher doses can induce side effects by damaging nontarget tissues. Combinatorial drug therapy may overcome these limitations by permitting lower doses and more specific targeting, thereby mitigating drug resistance and nontarget side effects. Recent reports indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) have anticancer potential and can be used together with conventional chemotherapeutics to improve efficacy and safety. In the present study, imatinib mesylate and dexketoprofen trometamol were selected as model drugs to develop targeted surface-modified liposome and nanocochleate formulations for fibrosarcoma treatment. The physicochemical properties and in vitro efficacy of various formulations were evaluated by measurement of particle size distribution, polydispersity index, zeta potential, encapsulation efficiency, diffusion through Caco-2 cells, and toxicity in culture. Selected formulations were then evaluated in fibrosarcoma-bearing model mice by histopathological observations and tyrosine kinase receptor inhibition assays.The most effective formulation on the fibrosarcoma model was a PEGylated nanocochleate formulation. These findings provide a foundation for developing more effective formulations and chemotherapeutic strategies for the treatment of fibrosarcoma and other types of cancer.

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Presence of Biogenic Amines in Food and Their Public Health Implications: A Review

Omer

Mohammed²,

Ameen³

et al. 2021

Journal of Food Protection

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Essential foods of a daily meal have been reported to comprise of numerous kinds of biogenic amines (BAs) at different levels. BAs have a variety of toxicological impacts on human health, and they have been connected to multiple outbreaks of foodborne disease. They also are known to cause cancer based on their ability to react with nitrite salts resulting in the production of a carcinogenic organic compound (i.e. nitrosamines). BAs toxicity is often linked to the ingestion of large quantities of BAs in food that causes toxicological threats and health disorders and has psychoactive, vasoactive, and hypertensive effects and can cause respiratory, gastrointestinal, cardiovascular and neurological disorders. Toxicity properties of BAs are linked closely to histamine and tyramine. Other amines, such as phenylethylamine, putrescine, and cadaverine are meaningful because they could increase histamine's negative effects. The key method for reducing BA concentration and foodborne disease is bacterial load management. It helps to control the formation of histamine and other BAs, and also reduce histamine and tyramine toxicity by applying basic good handling and hygiene practices. A greater understanding of BAs is essential to enhance food safety and quality. This review paper discusses the public health concerns of BAs in foods.

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The protective effects of cysteamine, putrescine, and the combination of cysteamineand putrescine on fibrosarcoma induced in mice with 3-methylcholanthrene

Cited by 3 publications

References 24 publications

Biochemical and Pharmacological Properties of Biogenic Amines

Biochemical and Pharmacological Properties of Biogenic Amines

Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma

Presence of Biogenic Amines in Food and Their Public Health Implications: A Review

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