The Protective Effects of High-Dose Ascorbic Acid on Myocardium against Reperfusion Injury During and After Cardiopulmonary Bypass

Dingchao, H; Zhiduan, Q; Hu, Liye; Xiao-dong, FU

doi:10.1055/s-2007-1016504

Cited by 64 publications

(82 citation statements)

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“…These results suggest that vitamin C suppresses the generation of free oxygen radicals, which then decreases the MDA level. Previously, Dingchao et al 15 reported that MDA levels decreased following the administration of high-dose vitamin C in patients undergoing open heart surgery. In addition, CPK-MB and lactate dehydrogenase (LDH) levels were lower in these patients, which may offer some protection for cardiac muscle.…”

Section: Discussionmentioning

confidence: 99%

Effect of High-Dose Vitamin C on Oxygen Free Radical Production and Myocardial Enzyme after Tourniquet Ischaemia–Reperfusion Injury during Bilateral Total Knee Replacement

2010

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This study investigated the effects of highdose vitamin C on oxygen free radical production and cardiac enzymes after tourniquet application and ischaemiareperfusion injury during bilateral total knee replacement (TKR) in elderly patients. In the vitamin C (VC) group (VC group, n = 16), during surgery, patients received a priming bolus of 0.06 g/kg vitamin C with 100 ml saline followed by 0.02 g/kg vitamin C mixed with 30 ml saline, intravenously. The control group (n = 16) received no intra-operative vitamin C. In the VC group, malondialdehyde levels were lower, and arterial oxygen tension and mean blood pressure were higher, than in controls after post-operative deflation of both knee tourniquets. Troponin I levels were lower in the VC group than in controls 8 h postoperation.Administering high-dose vitamin C during bilateral TKR could prevent oxygen free radical production and a decline in arterial oxygen tension and mean blood pressure induced by ischaemia-reperfusion injury, thereby protecting the myocardium.

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Section: Discussionmentioning

confidence: 99%

Effect of High-Dose Vitamin C on Oxygen Free Radical Production and Myocardial Enzyme after Tourniquet Ischaemia–Reperfusion Injury during Bilateral Total Knee Replacement

2010

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“…As these resources are exhausted, ROS are then able to react with biological moieties in an unregulated fashion, thus producing the detrimental effects listed above. Although there are considerable controversies regarding the efficacy of exogenous antioxidants during ischemia/reperfusion injury [65], positive results have been obtained in a variety of experimental and clinical settings [67][68][69][70]. Amongst the agents tested for efficacy during ischemia/reperfusion injury are various phenols.…”

Section: Acetaminophen and Reactive Oxygen Speciesmentioning

confidence: 99%

New Perspectives on Acetaminophen

Rork¹,

Hadzimichalis²,

Baliga³

et al. 2006

CCR

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Acetaminophen (paracetamol) continues to be one of the leading, international over-the-counter analgesics. Unlike the COX-2 inhibitors, no adverse cardiovascular effects have been associated with acetaminophen usage in safe, therapeutic dosages. There are few rigorous physiological investigations of its actions/mechanisms of action. Several investigations, in recent years, have questioned its potential activity in the mammalian cardiovascular system. Our laboratory has found some positive salutary effects in myocardial ischemia/reperfusion injury and during myocardial infarction. In addition, another laboratory found concomitant cardioprotective effects during the acute phase of myocardial infarction. They report similar effects of the ability of acetaminophen to reduce the severity of myocardial infarction and ultimately result in improved mortality rates. They also postulate that this attenuation in myocardial damage is mediated through antioxidant means. Others have not found similar results but have reported no detrimental cardiovascular actions of acetaminophen in experimental animals. The inconsistency in results probably reflects multiple differences in experimental approaches, including use of different species, different experimental preparations, different drug concentrations, and different routes/modes of administering/preparing the drug. The current review focuses on this recent research and tries to provide new perspectives for future investigations. In particular, we have identified new cellular/subcellular targets at which acetaminophen might be acting. These include matrix metalloproteinases and the mitochondrial permeability transition pore. Future work will help identify additional tissue/organ actions of acetaminophen and its as-yet-unknown mechanisms of action.

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“…Ebenso war der Herzindex in der Vitamin-C-Gruppe signifikant höher als in der Kontrollgruppe. Die Verweildauer auf der Intensivstation sowie der Krankenhausaufenthalt waren in der Behandlungsgruppe signifikant kürzer [13]. Die Ergebnisse dieser Arbeit deuten darauf hin, dass Vitamin C den ischämischen Reperfusionsschaden des Herzens während und nach offener Herzoperation vermindern kann.…”

Section: Antioxidantienunclassified

Der Einsatz von Antioxidantien beim Intensivpatienten

Manhart¹

2004

Visc Med

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Use of Antioxidants in Intensive Care Patients This article summarizes the available clinical studies regarding an antioxidative treatment in critically ill patients. There are several lines of evidence showing an increased oxidative stress during critical illness. The oxidative damage to cells and tissues possibly contributes to organ failure. Therefore a prophylactic or preventive treatment with antioxidants should reduce the oxidative stress and lead to an improved pathophysiological situation in critically ill patients. The results of the clinical studies found in the literature are contradictory because of heterogeneous patient populations, different antioxidants (single substances or combinations), different quantities, application times, start and/or duration of the study. From the present clinical data no firm conclusion for antioxidative treatment in critically ill patients can be drawn. Nevertheless, there is sufficient evidence from experimental studies suggesting that antioxidative therapy is an interesting treatment concept during critical illness.

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The Protective Effects of High-Dose Ascorbic Acid on Myocardium against Reperfusion Injury During and After Cardiopulmonary Bypass

Cited by 64 publications

References 0 publications

Effect of High-Dose Vitamin C on Oxygen Free Radical Production and Myocardial Enzyme after Tourniquet Ischaemia–Reperfusion Injury during Bilateral Total Knee Replacement

Effect of High-Dose Vitamin C on Oxygen Free Radical Production and Myocardial Enzyme after Tourniquet Ischaemia–Reperfusion Injury during Bilateral Total Knee Replacement

New Perspectives on Acetaminophen

Der Einsatz von Antioxidantien beim Intensivpatienten

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