The protective effects of resveratrol on Schwann cells with toxicity induced by ethanol in vitro

Yuan, Hongtu; Zhang, Jingfen; Liu, Huaxiang; Li, Zhenzhong

doi:10.1016/j.neuint.2013.05.011

Cited by 39 publications

(13 citation statements)

References 51 publications

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“…Quercetin and genistein were shown to stimulate NGF-induced neurite outgrowth [42,43]. Resveratrol is able to induce the release of BDNF and GDNF, thus protecting cells from neurotoxicity [44,45].…”

Section: Molecular Pathways Involved In Neuroprotection Of Polyphenolsmentioning

confidence: 99%

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Meo

Valentino²,

Petillo

et al. 2020

IJMS

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The interest in dietary polyphenols in recent years has greatly increased due to their antioxidant bioactivity with preventive properties against chronic diseases. Polyphenols, by modulating different cellular functions, play an important role in neuroprotection and are able to neutralize the effects of oxidative stress, inflammation, and apoptosis. Interestingly, all these mechanisms are involved in neurodegeneration. Although polyphenols display differences in their effectiveness due to interindividual variability, recent studies indicated that bioactive polyphenols in food and beverages promote health and prevent age-related cognitive decline. Polyphenols have a poor bioavailability and their digestion by gut microbiota produces active metabolites. In fact, dietary bioactive polyphenols need to be modified by microbiota present in the intestine before being absorbed, and to exert health preventive effects by interacting with cellular signalling pathways. This literature review includes an evaluation of the literature in English up to December 2019 in PubMed and Web of Science databases. A total of 307 studies, consisting of research reports, review articles and articles were examined and 146 were included. The review highlights the role of bioactive polyphenols in neurodegeneration, with a particular emphasis on the cellular and molecular mechanisms that are modulated by polyphenols involved in protection from oxidative stress and apoptosis prevention.

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Section: Molecular Pathways Involved In Neuroprotection Of Polyphenolsmentioning

confidence: 99%

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Meo

Valentino²,

Petillo

et al. 2020

IJMS

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“…Resveratrol ( Figure 11 ) prevented chronic cerebral hypofusion in the permanent vessel occlusion rat model by increasing hippocampal NGF, with an effect that persisted for 45 days following surgery, and leading to an improvement in behavioral assessment [ 92 ]. Ethanol toxicity-induced apoptosis of Schwann cells could be reversed by resveratrol treatment owing to adenosine monophosphate-activated protein kinase-mediated regulation of BDNF, GDNF, and NGF expression accompanied by inhibition of apoptosis in the peripheral neuronal system [ 123 ]. Previous studies revealed that resveratrol attenuates myocardial infract- (MI-) induced MCP-1- and IL-1 β -mediated inflammation and oxidative stress by modulating SOD and MDA levels and reducing MI-induced NGF level changes [ 124 ].…”

Section: Role Of Dietary Phytochemicalsmentioning

confidence: 99%

Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review

Venkatesan

Kim

2015

BioMed Research International

150

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Alzheimer's disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem. Age, nutrition, and toxins are the most common causes of AD. However, currently no credible treatment is available for AD. Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties. They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors. Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD. Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease. Here, we review the phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75NTR superfamily. We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection. Although these phytochemicals have attracted attention owing to their in vitro neurotrophin potentiating activity, their in vivo and clinical efficacy trials has yet to be established. Therefore, further research is necessary to prove the neuroprotective effects in preclinical models and in humans.

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“…Spp1 is expressed in a range of immune cells and reported to act as an immune modulator, which promotes cell recruitment to inflammatory sites [17]. It also functions as an adhesion protein involved in cell attachment and wound healing [17, 18]. Stimulation of Spp1 expression leads to an increase in cell pro-inflammatory cytokine levels, although the regulatory pathways are not yet known [17–19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury

Liu

Sun

et al. 2017

BMC Neurosci

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BackgroundWallerian degeneration (WD) in injured peripheral nerves is associated with a large number of up- or down-regulated genes, but the effects of these changes are poorly understood. In our previous studies, we reported some key factors that are differentially expressed to activate nerve degeneration and regeneration during WD. Here, we determined the effects of secreted phosphoprotein 1 (Spp1) on WD after rat sciatic nerve injury.ResultsSpp1 was upregulated from 6 h to 14 days after sciatic nerve injury. Altered expression of Spp1 in Schwann cells (SC) resulted in altered mRNA and protein expression levels for cytokines, c-Fos, PKCα and phospho-ERK/ERK and affected SC apoptosis in vitro. Silencing of Spp1 expression in SCs using siRNA technology reduced proliferation and promoted migration of SCs in vitro. By contrast, overexpression of Spp1 promoted proliferation and reduced migration in SCs in vitro. Differential expression of Spp1 after sciatic nerve injury in vivo altered the expression of cytokines, c-Fos, PKCα, and the p-ERK/ERK pathway.ConclusionsSpp1 is a key regulatory factor that affects nerve degeneration and regeneration through c-Fos, PKCα and p-ERK/ERK pathways after rat sciatic nerve injury. These results shed new light on the role of Spp1 in nerve degeneration and regeneration during WD.

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The protective effects of resveratrol on Schwann cells with toxicity induced by ethanol in vitro

Cited by 39 publications

References 51 publications

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration

Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review

Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury

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