The protective effects of Resveratrol against radiation-induced intestinal injury

Zhang, Heng; Yan, Huimin; Zhou, Xiaoliang; Wang, Huaqing; Yang, Yiling; Zhang, Junling; Wang, Hui

doi:10.1186/s12906-017-1915-9

Cited by 74 publications

(49 citation statements)

References 45 publications

(53 reference statements)

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“…It can ameliorate oxidative stress, DNA damage, apoptosis and subsequent consequences following exposure to gamma radiation in mice intestinal tissue. These radioprotective effects are mediated by acetylation of p53 and activation of Sir1, resulting in resistance of intestinal crypt cells to apoptosis [135]. Administering resveratrol before irradiation of rats' abdomen with 10 Gy could ameliorate increased level of inflammatory cytokine, regulatory T cells, and oxidative DNA damage, whereas it increased the white blood cell counts such as CD4+ T cells [136].…”

Section: Resveratrolmentioning

confidence: 99%

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Yahyapour

Shabeeb

Cheki

et al. 2018

CMP

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Section: Resveratrolmentioning

confidence: 99%

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Yahyapour

Shabeeb

Cheki

et al. 2018

CMP

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“…Zhang et al [ 41 ] investigated the effects of resveratrol against radiation-induced small intestine injury in mice. In this study, the mice were pretreated with resveratrol 5 days before and 1 day after prior to a large single dose partial-body (abdominal) irradiation.…”

Section: Introductionmentioning

confidence: 99%

Radioprotective agents to prevent cellular damage due to ionizing radiation

et al. 2017

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Medical imaging has become a central component of patient care to ensure early and accurate diagnosis. Unfortunately, many imaging modalities use ionizing radiation to generate images. Ionizing radiation even in low doses can cause direct DNA damage and generate reactive oxygen species and free radicals, leading to DNA, protein, and lipid membrane damage. This cell damage can lead to apoptosis, necrosis, teratogenesis, or carcinogenesis. As many as 2% of cancers (and an associated 15,000 deaths annually) can be linked to computed tomography exposure alone. Radioprotective agents have been investigated using various models including cells, animals, and recently humans. The data suggest that radioprotective agents working through a variety of mechanisms have the potential to decrease free radical damage produced by ionizing radiation. Radioprotective agents may be useful as an adjunct to medical imaging to reduced patient morbidity and mortality due to ionizing radiation exposure. Some radioprotective agents can be found in high quantities in antioxidant rich foods, suggesting that a specific diet recommendation could be beneficial in radioprotection.

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“…26,27 Under physiological conditions, epithelial homeostasis is maintained by proliferative cells in crypts, and the small intestinal crypt Many studies have shown that IR-induced tissue damage increases the amount of apoptotic cells. [31][32][33] Caspases are a family of genes important for maintaining homeostasis by regulating apoptosis and inflammation. 34 Caspases involved in apoptosis have been subclassified by their mechanism of action into initiator caspases (caspase-8 and -9) and executioner caspases (caspase-3, -6 and -7).…”

Section: Discussionmentioning

confidence: 99%

The protective effects of XH‐105 against radiation‐induced intestinal injury

Cheng

Dong

Hou

et al. 2019

J Cellular Molecular Medi

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Radiation‐induced intestinal injury is one of the major side effects in patients receiving radiation therapy. There is no specific treatment for radiation enteritis in the clinic. We designed and synthesized a new compound named XH‐105, which is expected to cleave into polyphenol and aminothiol in vivo to mitigate radiation injury. In the following study, we describe the beneficial effects of XH‐105 against radiation‐induced intestinal injury. C57BL/6J mice were treated by gavage with XH‐105 1 hour before total body irradiation (TBI), and the survival rate was monitored. Histological changes were examined, and survival of Lgr5 + intestinal stem cells Ki67 + cells, villi + enterocytes and lysozymes was determined by immunohistochemistry. DNA damage and cellular apoptosis in intestinal tissue were also evaluated. Compared to vehicle‐treated mice after TBI, XH‐105 treatment significantly enhanced the survival rate, attenuated structural damage of the small intestine, decreased the apoptotic rate, reduced DNA damage, maintained cell regeneration and promoted crypt proliferation and differentiation. XH‐105 also reduced the expression of Bax and p53 in the small intestine. These data suggest that XH‐105 is beneficial for the protection of radiation‐induced intestinal injury by inhibiting the p53‐dependent apoptosis signalling pathway.

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The protective effects of Resveratrol against radiation-induced intestinal injury

Cited by 74 publications

References 45 publications

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Radiation Protection and Mitigation by Natural Antioxidants and Flavonoids: Implications to Radiotherapy and Radiation Disasters

Radioprotective agents to prevent cellular damage due to ionizing radiation

The protective effects of XH‐105 against radiation‐induced intestinal injury

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