2020
DOI: 10.1007/s11356-020-10351-9
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The protective efficacy of vitamin E and cod liver oil against cisplatin-induced acute kidney injury in rats

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Cited by 28 publications
(21 citation statements)
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“…The result attributed to Vit E treatment that inhibited the body weight loss as it weakens ROS signals required for adipose tissue expansion due to its antioxidant activity. This result came in accordance with Abo-Elmaaty [18] who confirmed Vit E (100 mg/kg BW) preventive role against cisplatin-inducing acute kidney damage because of its ability to return body weights of rats to normal control values. The pathogenesis of various diseases is influenced by oxidative stress.…”
Section: Discussionsupporting
confidence: 89%
“…The result attributed to Vit E treatment that inhibited the body weight loss as it weakens ROS signals required for adipose tissue expansion due to its antioxidant activity. This result came in accordance with Abo-Elmaaty [18] who confirmed Vit E (100 mg/kg BW) preventive role against cisplatin-inducing acute kidney damage because of its ability to return body weights of rats to normal control values. The pathogenesis of various diseases is influenced by oxidative stress.…”
Section: Discussionsupporting
confidence: 89%
“…We were also unable to verify an association between AKD and platinum‐derived chemotherapeutics (Table 4), perhaps due to the method used for infusion, or due to the predominance of patients treated with CARBO and OXA, which are less or non‐nephrotoxic drugs 16,22 . However, upon analysis of survival curves of patients who presented with AKD after the start of chemotherapy we found that patients with AKD during treatment had the lowest survival (Figure 4), which is compatible with previous studies 11,21,26‐30 …”
Section: Discussionsupporting
confidence: 80%
“…However, CIS administration has been accompanied by nephrotoxicity, cardiotoxicity, hepatotoxicity, and ovarian toxicity. [13][14][15][16][17][18] Previous research suggests that CIS induces cytotoxicity in healthy tissue via continuous generation of reactive oxygen species (ROS), suppressing endogenous antioxidant enzymes, releasing free radicals, and inducing mitochondrial oxidative stress. [19,20] The continued generation of free radicals in the cells is responsible for inducing the pathogenic phase.…”
Section: Introductionmentioning
confidence: 99%