The Protective Influence of Selenium on Oxidant Disturbances in Brain of Rats Exposed to Lithium

Kiełczykowska, Małgorzata; Kocot, Joanna; Lewandowska, Anna; Żelazowska, Renata; Musik, Irena

doi:10.33549/physiolres.932910

Cited by 13 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore we can suggest that the increase in GSH levels observed in NIC180 + NAC and NAC270 + NIC groups has the ability to scavenge the superoxide radical thus leading to a redox homeostasis. The fact that decreases in SOD activity were also observed by the administration of the anti-kindling drugs lithium and valproate (Jornada et al 2011;Kiełczykowska et al 2015) deserves mention. Overall, our results suggest that GSH is an important parameter related to the protection against NIC kindling.…”

Section: Discussionmentioning

confidence: 99%

N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats

Okamura

Gomes

Oliveira

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

Kindling is a form of behavioral sensitization that is related to the progression of several neuropsychiatric disorders such as bipolar disorder. We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To do this female Wistar rats at postnatal day 30 received repeated injections of NIC 2mg/kg, i.p. every weekday for up to 19 days. NAC90, 180 or 270 mg/kg, i.p. was administered 30 min before NIC. The levels of glutathione (GSH), superoxide dismutase (SOD) activity, lipid peroxidation (LP) and nitrite were determined in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). The development of kindling occurred at a median time of 16.5 days with 87.5% of NIC animals presenting stage 5 seizures in the last day of drug administration. NAC270 prevented the occurrence of kindling. NIC-kindled animals presented decreased levels of GSH and increased LP in the PFC, HC and ST, while SOD activity was decreased in the ST. NAC180 or 270 prevented the alterations in GSH induced by NIC, but only NAC270 prevented the alterations in LP. Nitrite levels increased in the ST of NAC270 pretreated NIC-kindled animals. Taken together we demonstrated that NAC presents anti-kindling effects in female animals partially through the restoration of oxidative alterations.

show abstract

Section: Discussionmentioning

confidence: 99%

N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats

Okamura

Gomes

Oliveira

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…Group I received 1 ml of distilled water orally for 28 days and served as control group; Group II was received oral administration of o.5 mg/kg of selenium for 28 days. Group III (lead intoxicated rats) was exposed to lead acetate through drinking water for 28 days and served as the lead control group; Group IV was exposed to lead through drinking water and received oral 0.5 mg/kg of selenium concomitantly for 28 days; The dose of selenium was selected based on previous studies (Kiełczykowska et al, 2015). Preparation of leaded water (0.2 % lead): 5 g of lead acetate (CH3COO)2Pb•3H2O) was dissolved in 2.5 L of distilled water (Abdulmajeed et al, 2015).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Selenium Nephroprotection through Inhibition of PERKEIF2α- CHOP Pathway in Lead Intoxicated Male Rats

Rashed

Wakel

Hussin

et al. 2021

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

Background: Lead contamination has turned into a major concern as it serves no useful purpose in the human body. Its presence in the body can lead to toxic effects on different organs. Aim:The purpose of the present study is to examine the efficacy of selenium in mitigating leadinduced oxidative stress and kidney injury in male albino Wistar rats. Further to study the underlying molecular mechanism. Methods: We hypothesized that selenium protect against lead nephrotoxicity by testing various parameters of kidney function in male rats treated for 28 days with o.5 mg/kg selenium versus control male rats that received a vehicle. Results: The results showed an increase of serum urea, creatinine, uric acid and urinary albumin in rats intoxicated with lead compared to control group. The increase of these parameters would indicate renal toxicity which is confirmed by histopathological changes. Lead intoxicated rats had significant increment in apoptosis as well as phosphorylated PERK, eIF2α and apoptotic proteins as CHOP, caspase 3 and 8 in the kidneys, which were attenuated by selenium treatment. Conclusion: This study clearly demonstrated that activation of PERK-eIF2α -CHOP signaling pathway was involved in lead induced nephrotoxicity in rats and selenium inhibited lead nephrotoxicity partly through suppression of PERK-eIF2α CHOP pathway.

show abstract

“…Group III (Phenytoin+ Selenium): contained fifteen rats, each rat received phenytoin as group II in addition to selenium at a dose of 0.5 mg/kg BW/day [15] orally by gastric tube for 45 days.…”

Section: Rats Were Equally Divided Into Three Groupsmentioning

confidence: 99%

The possible protective role of selenium against long-term phenytoin administration effects on cerebellar cortex of adult male albino rats: Histological and immunohistochemical study

Bekheet

2019

Egyptian Journal of Histology

View full text Add to dashboard Cite

Background: Phenytoin is a commonly prescribed antiepileptic drug. Chronic phenytoin treatment has been documented to be associated with cerebellar degeneration. Selenium is one of the main antioxidant coenzymes of glutathione peroxidase and it is a key component of seleno-proteins that play important roles in brain development and metabolism. Aim: This work aimed to study the possible protective role of selenium against long-term phenytoin administration effects on cerebellar cortex of the adult male albino rats. Material and Methods: Forty-five adult male albino rats were used in this study, aged from 6-8 months, weighting 180 -200 gm. Rats were equally divided into three groups: Group I: rats were further equally subdivided into: group IA: kept as negative control, group IB: each rat received 1ml of distilled water /day orally for 45 days and group IC: each rat received selenium at a dose of 0.5 mg/kg BW(body weight)/day orally for 45 days. Group II: each rat received phenytoin at a dose of 20mg/ Kg BW /day orally for 45 days. Group III: each rat received phenytoin as group II in addition to selenium at a dose of 0.5 mg/kg BW/day orally for 45 days. Results: The present work revealed that long term phenytoin administration induced histological changes of rat's cerebellar cortex in the form of decreased thickness, irregular deeply stained Purkinje cells and increased perineural space around Purkinje cells and granule cells. Selenium administration with phenytoin nearly preserved the histological structure of the cerebellar cortex. Conclusion:Long term phenytoin administration led to histoarchitectural changes of rat's cerebellar cortex. However, Selenium administration with phenytoin greatly protected the cerebellar cortex from such changes.

show abstract

The Protective Influence of Selenium on Oxidant Disturbances in Brain of Rats Exposed to Lithium

Cited by 13 publications

References 51 publications

N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats

N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats

Selenium Nephroprotection through Inhibition of PERKEIF2α- CHOP Pathway in Lead Intoxicated Male Rats

The possible protective role of selenium against long-term phenytoin administration effects on cerebellar cortex of adult male albino rats: Histological and immunohistochemical study

Contact Info

Product

Resources

About