The protective of hydrogen on stress-induced gastric ulceration

Li, Xinwei; Chen, Zhi; Mao, Ningfang; Xie, Yang

doi:10.1016/j.intimp.2012.04.004

Cited by 33 publications

(21 citation statements)

References 23 publications

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“…Overactivati on of PARP, associate d with oxidative stress, represents an important mechanism of tissue damage in various pathological conditions (Tasatargil et al, 2009 ). On the other hand, caspases are known to play essential roles during apoptotic cell death (Liu et al, 2012 ). There are two types of caspases: initiator caspases (caspase 2,8,9,10) and effector caspases (caspase 3,6,7).…”

Section: Discussionmentioning

confidence: 99%

“…The specific morphological changes associated with apoptosis are cell shrinkage, chromatin condensation, internucleos omal DNA fragmentation , and the formation of apoptotic bodies (Bohm and Schild, 2003;Chandra et al, 2000 ). The majority of morphological and biochemical changes are the result of various enzymatic reactions most of which are catalyzed by caspases playing essential roles during apoptotic cell death (Bohm and Schild, 2003;Liu et al, 2012 ). The signaling cascades that control caspase-dep endent apoptosis can be classified into two pathways: the extrinsic cell death (or death receptor) pathway and the intrinsic (or mitochondrial) death pathway.…”

Section: Introductionmentioning

confidence: 99%

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Ghrelin inhibits sodium metabisulfite induced oxidative stress and apoptosis in rat gastric mucosa

Ercan

Basaranlar

Gungor

et al. 2013

Food and Chemical Toxicology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ghrelin inhibits sodium metabisulfite induced oxidative stress and apoptosis in rat gastric mucosa

Ercan

Basaranlar

Gungor

et al. 2013

Food and Chemical Toxicology

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“…Therefore, the low ghrelin (even after iron supplementation) might be consistent with the view that the body is attempting to deal with these problems by consuming ghrelin [33]. Hydroxyl radical, produced by the iron-catalyzed Haber-Weiss reaction, might also damage gastric mucosal cells [27,35]. This hormone is produced mainly by P/D1 cells lining the fundus of stomach (reviewed [33]).…”

Section: Discussionmentioning

confidence: 65%

Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

Uğur

Aydın

Dönder

et al. 2018

Preprint

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Ghrelin and obestatin, two antagonist peptide hormones, are purportedly involved in stimulating appetite and controlling energy balance in humans. Serum ghrelin level is also associated with iron deficiency anemia (IDA), but no study has yet been made of the obestatin level in patients with IDA, even though both hormones are a single gene product. Therefore, the purpose of this investigation is to see whether there is a link between IDA and these two hormones among other hematological parameters in patients with IDA. To measure ghrelin and obestatin, human saliva and serum were collected from 30 women with IDA, aged 31.7 ± 10.7 years, and 30 control women, aged 30.2 ± 8.0 years, with repeated collection of samples over a period of 1 week and 1 month. Saliva and serum ghrelin levels were measured by ELISA. Serum hemoglobin, ferritin, hematocrit and total iron-binding capacity (TIBC) values were determined with an Olympus AU2700. Saliva and serum ghrelin and obestatin levels were significantly lower in the IDA group compared with controls; these levels increased slightly above baseline with iron treatment, but remained below the control values.Furthermore, and as expected, serum hemoglobin, ferritin, and hematocrit levels were 2 significantly increased with iron treatment, while total iron-binding capacity decreased compared to baseline concentrations. The findings suggest that IDA might be linked to imbalance of circulating (serum) and non-circulating (saliva) ghrelin and obestatin levels.Decreased ghrelin and obestatin might destroy iron homeostasis through its effect on intestinal absorption. Measuring these hormone levels might be useful for monitoring the response to iron treatment. Also, serum and saliva levels for both hormones were well correlated. Thus, using saliva in place of serum for monitoring the two hormones should minimize inconvenience and patient discomfort.

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“…In recent years, an increasing number of reports have investigated the preventative and therapeutic effects of H 2 in many diseases and organs, such as stress-induced gastric ulceration [16], acute carbon monoxide poisoning in rats [17], intestinal [18] and myocardial [19] ischemia-reperfusion injuries in rats, and radiation-induced immune dysfunction in mice [20]. However, there is no in vivo evidence that HS injection is an effective approach for the treatment of hSCI-induced decreased testicular function.…”

Section: Discussionmentioning

confidence: 99%

“…Intraperitoneal or intravenous HS injection to various animal models have been met with great success. HS administration was found to attenuate stress-induced gastric ulceration [16], acute carbon monoxide poisoning in rats [17], intestinal [18] and myocardial [19] ischemia-reperfusion injuries in rats, and radiation-induced immune dysfunction in mice [20]. In our previous study, we found that HS administration could reduce retinal excitotoxic injury and promote retinal recovery in glutamate-induced excitotoxic injury guinea pig model [21].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats

Wei

Cheng

et al. 2017

Oncotarget

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To study how hydrogen-rich saline (HS) promotes the recovery of testicular biological function in a hemi-sectioned spinal cord injury (hSCI) rat model, a right hemisection was performed at the T11–T12 of the spinal cord in Wistar rats. Animals were divided into four groups: normal group; vehicle group: sham-operated rats administered saline; hSCI group: subjected to hSCI and administered saline; HRST group: subjected to hSCI and administered HS. Hind limb neurological function, testis index, testicular morphology, mean seminiferous tubular diameter (MSTD) and seminiferous epithelial thickness (MSET), the expression of heme oxygenase-1 (HO-1), mitofusin-2 (MFN-2), and high-mobility group box 1 (HMGB-1), cell ultrastructure, and apoptosis of spermatogenic cells were studied. The results indicated that hSCI significantly decreased the hind limb neurological function, testis index, MSTD, and MSET, and induced severe testicular morphological injury. The MFN-2 level was decreased, and HO-1 and HMGB-1 were overexpressed in testicular tissues. In addition, hSCI accelerated the apoptosis of spermatogenic cells and the ultrastructural damage of cells in the hypophysis and testis. After HS administration, all these parameters were considerably improved, and the characteristics of hSCI testes were similar to those of normal control testes. Taken together, HS administration can promote the recovery of testicular biological function by anti-oxidative, anti-inflammatory, and anti-apoptotic action. More importantly, HS can inhibit the hSCI-induced ultrastructural changes in gonadotrophs, ameliorate the abnormal regulation of the hypothalamic-pituitary-testis axis, and thereby promote the recovery of testicular injury. HS administration also inhibited the hSCI-induced ultrastructural changes in testicular spermatogenic cells, Sertoli cells and interstitial cells.

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The protective of hydrogen on stress-induced gastric ulceration

Cited by 33 publications

References 23 publications

Ghrelin inhibits sodium metabisulfite induced oxidative stress and apoptosis in rat gastric mucosa

Ghrelin inhibits sodium metabisulfite induced oxidative stress and apoptosis in rat gastric mucosa

Saliva and Serum Ghrelin and Obestatin in Iron Deficiency Anemia Patients

Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats

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