The protective role of ascorbic acid in the hepatotoxicity of cadmium and mercury in rabbits

Mumtaz, Sadaf; Ali, Shaukat; Khan, Rizwan Taj; Andleeb, Saiqa; Ulhaq, Mazhar; Khan, Muhammad Azmat Ullah; Shakir, Hafiz Abdullah

doi:10.1007/s11356-019-04620-5

Cited by 43 publications

(21 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Group III: ACR + Ascorbic acid group: Rats were treated with both ascorbic acid (150 mg/kg of body weight per day orally) (Mumtaz et al, 2019) and ACR (50 mg per kg of body weight per day IP) for 14 days; the time interval between treatments is 1 h.…”

Section: Methodsmentioning

confidence: 99%

Role of Ascorbic Acid Versus Silymarin in Amelioration of Hepatotoxicity Induced by Acrylamide in Adult Male Albino Rats: Histological and Immunohistochemical Study

2020

View full text Add to dashboard Cite

Acrylamide (ACR) is a cytotoxic and carcinogenic material. It is a product of a Maillard reaction during the cooking of many types of fried fast food, e.g. potato chip fries, and chicken nuggets. ACR has a severe toxic effect on different body organs. This study investigates the hepatotoxic effect of ACR, and the protective effect of ascorbic acid and silymarin. For this purpose, forty adult, male, albino rats were divided into four groups and received the following treatments for fourteen days: Group I: (the control) normal saline; Group II: ACR only; Group III: ACR and ascorbic acid; and Group IV: ACR and silymarin. Under a light microscope, the liver from rats treated with ACR only presented disturbed liver architecture, degenerated hepatocytes, reduced glycogen contents, congested central vein, and increased collagen fibres with areas of fibrosis. Immunohistochemical examination revealed an increased mean number of CD68-, and α-SMA-positive cells. This indicates the presence of large numbers of stellate macrophages (Kupffer cells) and Hepatic stellate cells (HSCs). The combination of ACR with either ascorbic acid or silymarin resulted in less hepatic degeneration, less fibrosis and fewer CD68 and α-SMA positive cells compared to the ACR only group. In conclusion, treatment with silymarin or ascorbic acid along with ACR appears to alleviate ACR-induced hepatotoxicity with more protection in silymarin treated rats.

show abstract

Section: Methodsmentioning

confidence: 99%

Role of Ascorbic Acid Versus Silymarin in Amelioration of Hepatotoxicity Induced by Acrylamide in Adult Male Albino Rats: Histological and Immunohistochemical Study

2020

View full text Add to dashboard Cite

show abstract

“…All animal trial techniques were directed as per local and worldwide controls. The nearby direction is the Wet op de dierproeven (Article 9) of Dutch Law (International) as detailed in our previous studies (Ali et al, 2020a;Ali et al, 2020b;Hussain et al, 2020;Ara et al, 2020;Ali et al, 2019;Khan et al, 2019;Mumtaz et al, 2019;Mughal et al, 2019;Dar et al, 2019) and The Institutional Bioethics Committee at Government College University Lahore, Pakistan (No. GCU/IIB/21 dated: 08-01-2019).…”

Section: Ethical Statementmentioning

confidence: 99%

Silk derived formulations for accelerated wound healing in diabetic mice

Tariq¹,

Tahir²,

Butt³

et al. 2021

PeerJ

Self Cite

View full text Add to dashboard Cite

Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

show abstract

Section: Ethical Statementmentioning

confidence: 99%

Peer Review #4 of "Silk derived formulations for accelerated wound healing in diabetic mice (v0.2)"

2021

View full text Add to dashboard Cite

Background: The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods: Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis.Results: The results indicated that the best biocompatible silk combination was of 5 % silk fibroin and 5 % Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5±0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion: It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

show abstract

The protective role of ascorbic acid in the hepatotoxicity of cadmium and mercury in rabbits

Cited by 43 publications

References 38 publications

Role of Ascorbic Acid Versus Silymarin in Amelioration of Hepatotoxicity Induced by Acrylamide in Adult Male Albino Rats: Histological and Immunohistochemical Study

Role of Ascorbic Acid Versus Silymarin in Amelioration of Hepatotoxicity Induced by Acrylamide in Adult Male Albino Rats: Histological and Immunohistochemical Study

Silk derived formulations for accelerated wound healing in diabetic mice

Peer Review #4 of "Silk derived formulations for accelerated wound healing in diabetic mice (v0.2)"

Contact Info

Product

Resources

About