The protective role of DMBT1 in cervical squamous cell carcinoma

Zhang, Chunxiao

doi:10.1002/kjm2.12117

Cited by 7 publications

(8 citation statements)

References 39 publications

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“…In the present report we showed that DMBT1 expression levels were down regulated in cervical cancer tissues and its low expression was associated with poor prognosis and dismal outcome. Similar results were found by previous studies (14). Zhang (14) showed that mRNA and tissue protein DMBT1 levels were downregulated in cervical cancer tissues in comparison to normal cervical mucosa.…”

Section: Discussionsupporting

confidence: 90%

“…Similar results were found by previous studies (14). Zhang (14) showed that mRNA and tissue protein DMBT1 levels were downregulated in cervical cancer tissues in comparison to normal cervical mucosa. These findings collectively showed DMBT1 tumor suppressor role in cervical cancer.…”

Section: Discussionsupporting

confidence: 90%

“…Loss of DMBT1 expression in colorectal cancer was associated with unfavorable prognosis and was a predictive factor for disease recurrence (28). Moreover, Zhang (14) found that overexpression of DMBT1 promotes apoptosis and inhibits proliferation of cervical cancer cells which might be a possible explanation of our results. Zhang ( 14 a marked reduction in the expression of the anti-apoptosis protein (Bcl-2) in cancer cells with higher DMBT1 expression.…”

Section: Discussionmentioning

confidence: 66%

“…It was found that disturbances in the PI3K-AKT signaling pathway was incriminated in EMT induction and in controlling cancer progression (29) Shen et al (13) showed that higher expression of DMBT1 could be able to control PI3KAKT pathway by which it inhibits gall bladder cancer migration and invasion. Zhang et al, (14) showed that increased DMBT1 expression led to reduction in the expression of Vimentin and N-cadherin and up-regulation of E-cadherin so DMBT1 was able to inhibit EMT reducing cancer cells invasion and spread.…”

Section: Discussionmentioning

confidence: 99%

“…Deleted in malignant brain tumor 1 (DMBT1), which is mapped on chromosome 10q25.3-26.1, was primarily discovered in glioblastoma and medulloblastoma as deleted, hence responsible for their progression and dismal outcome (12). Recently, decreased DMBT1 expression was found in many cancers during their progression (13,14) NR2F6, LOXL2 and DMBT1 expression in cervical cancer was not sufficiently clarified. Aim of the present work was to assess expression of NR2F6, LOXL2 and DMBT1 in cervical cancer tis-sues using immunohistochemistry then correlating their expression with grade and stage of the tumor, occurrence of lymph nodes and distant metastases in addition to evaluating their prognostic roles.…”

Section: Introductionmentioning

confidence: 99%

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NR2F6, LOXL2 and DMBT1 expression in cervical cancer tissues, prognostic and clinicopathological implications

et al. 2021

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Background. Detection of novel predictive markers for early detection of lymph nodes metastases in cervical cancer is very important. Disturbed NR2F6 expression was found in many cancers playing different roles according to cancer type. LOXL2 was incriminated in cancer progression and unfavorable survival in many cancer types. Decreased DMBT1 expression was found in many cancers during their progression. Aim of the present work was to assess expression of NR2F6, LOXL2 and DMBT1 in cervical cancer tissues using immunohistochemistry then correlating their expression with grade and stage of the tumor, occurrence of lymph nodes and distant metastases in addition to evaluating their prognostic roles. Materials and methods. We assessed the expression of NR2F6, LOXL2 and DMBT1 in samples retrieved from sixty two cervical cancer patients in cancer tissues and corresponding adjacent normal tissues and we correlated markers expression with clinical data, pathological findings and patients' prognosis. Results. High expression of NR2F6, LOXL2 and low expression of DMBT1 was up-regulated in cervical cancer tissues more than in adjacent non-neoplastic cervical tissues and was associated with high grade (p = 0.005), lymphovascular space involvement, advanced FIGO stage, resistance to chemotherapy, tumor recurrence, and shorter survival rates (p < 0.001). Conclusions. Up regulation of NR2F6, LOXL2 and down regulation of DMBT1 were associated with unfavorable pathological parameters, bad clinical findings and dismal outcome of cervical cancer patients. SOMMARIOContesto. La rilevazione di nuovi marcatori predittivi per la diagnosi precoce delle metastasi linfonodali nel cancro cervicale è molto importante. L'espressione distorta di NR2F6 è stata trovata in molti tumori che svolgono ruoli diversi a seconda del tipo di cancro. LOXL2 è stato incriminato nella progressione del cancro e nella sopravvivenza sfavorevole in molti tipi di cancro. La diminuzione dell'espressione di DMBT1 è stata trovata in molti tumori durante la loro progressione. Lo scopo del presente lavoro era valutare l'espressione di NR2F6, LOXL2 e DMBT1 nei tessuti del cancro cervicale mediante immunoistochimica, quindi correlando la loro espressione con il grado e lo stadio del tumore, la presenza di linfonodi e metastasi a distanza, oltre a valutare i loro ruoli prognostici. Materiali e metodi. Abbiamo valutato l'espressione di NR2F6, LOXL2 e DMBT1 in campioni prelevati da sessantadue pazienti con cancro cervicale nei tessuti tumorali e nei corrispondenti tessuti normali adiacenti e abbiamo correlato l'espressione dei marcatori con i dati clinici, i risultati patologici e la prognosi dei pazienti. Risultati. L'alta espressione di NR2F6, LOXL2 e la bassa espressione di DMBT1 erano sovraregolate nei tessuti del cancro cervicale più che nei tessuti cervicali adiacenti non neoplastici ed erano associate ad alto grado (p = 0,005), coinvolgimento dello spazio linfovascolare, stadio FIGO avanzato, resistenza a chemioterapia, recidiva del tumore e tassi di sopravvivenza pi...

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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NR2F6, LOXL2 and DMBT1 expression in cervical cancer tissues, prognostic and clinicopathological implications

et al. 2021

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DMBT1 suppresses cell proliferation, migration and invasion in ovarian cancer and enhances sensitivity to cisplatin through galectin‐3/PI3k/Akt pathway

Zhao

2020

Cell Biochemistry & Function

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Ovarian cancer (OC) is one of the most common gynaecologic malignancies. Deleted in malignant brain tumors 1 (DMBT1) was considered as a tumour suppressor in multiple cancers, but there have been no systemic profiling studies of DMBT1 in OC until now. The aim of this study is to explore the role and the potential mechanism of DMBT1 in OC. mRNA levels and protein expressions of corresponding genes were detected by quantitative real‐time polymerase chain reaction and western blot. Cell proliferation was detected by CCK‐8 assay and cell colony formation. Cell migration and invasion were detected by wound healing and transwell assay. The combination between DMBT1 and galectin‐3 was demonstrated by immunoprecipitation. We demonstrated that DMBT1 was downregulated in OC cell lines, especially SKOV3 cells. Overexpression of DMBT1 significantly inhibited cell proliferation, colony formation, migration and invasion, as well as decreased Matrix Metalloproteinase‐2 (MMP‐2) and MMP‐7. DMBT1 caused a reduction of cell viability by treatment with cisplatin. Immunoprecipitation assay revealed a combination between DMBT1 and galectin‐3. DMBT1 could decrease the expression of galectin‐3 and inhibit the phosphorylation of PI3K and AKT, while overexpression of galectin‐3 reversed this effect. In summary, DMBT1 might inhibit the progression of OC and improve the sensitivity of SKOV3 cells to cisplatin through galectin‐3/PI3K/AKT pathway, giving a new insight into the role of DMBT1 in OC and enriching the potential strategies for OC treatment.Significance of the StudyThe present study focus on the role and the potential mechanism of DMBT1 in ovarian cancer (OC). We demonstrated that DMBT1 might inhibit the progression of ovarian by inhibiting cell proliferation, migration and invasion and increased the sensitivity to cisplatin through galectin‐3/PI3K/AKT pathway. The findings ensure the interaction relation between DMBT1 and galectin‐3 in OC, providing a novel biological marker for OC and enriching the potential strategies for OC treatment.

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Chicory root flour – A functional food with potential multiple health benefits evaluated in a mice model

Pouille

Jégou

Dugardin

et al. 2020

Journal of Functional Foods

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The protective role of DMBT1 in cervical squamous cell carcinoma

Cited by 7 publications

References 39 publications

NR2F6, LOXL2 and DMBT1 expression in cervical cancer tissues, prognostic and clinicopathological implications

NR2F6, LOXL2 and DMBT1 expression in cervical cancer tissues, prognostic and clinicopathological implications

DMBT1 suppresses cell proliferation, migration and invasion in ovarian cancer and enhances sensitivity to cisplatin through galectin‐3/PI3k/Akt pathway

Chicory root flour – A functional food with potential multiple health benefits evaluated in a mice model

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