The protective role of Gongronema latifolium in acetaminophen induced hepatic toxicity in Wistar rats

Johnkennedy, Nnodim; Adamma, Emejulu

doi:10.1016/s2221-1691(11)60145-7

Cited by 21 publications

(9 citation statements)

References 23 publications

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“…In vitro antioxidant potential of a compound is inversely proportional to its EC50 value. In this regard, Lee et al, 2008 reported that EC50 value of <10 mg/mL suggests that A. davisii has effective antioxidant activity [19]. In our study, the EC50 values of A. davisii extract was found to be less than 10 mg/mL that confirm the effectiveness of the extract as antioxidant.…”

Section: Estimation Of In Vitro Antioxidant Effectsupporting

confidence: 73%

“…Liver is among the most important organs involved in metabolic activities. Hepatocellular injury induced by PCM overdose has been documented by a number of studies [19][20]. In this study, the potential hepatoprotective effect of In our study, the oral administration of PCMoverdose showed drastic elevation in the level of serum marker enzymes when compared with normal rats, indicating PCM mediated hepatic damages.…”

Section: Hepatoprotective Activitysupporting

confidence: 56%

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The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats

Foudah

Alqarni

Soliman

et al. 2020

JPRI

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The current study aimed to estimate in vitro antioxidant effect of Astragalus davisii (A. davisii) extract. Further, the possible protective effect of A. davisii against paracetamol (PCM)-induced liver injury was assessed in rats. A. davisii was tested for its antioxidant activity using DPPH radical scavenging assay. The hepatoprotective potential of the extract was assessed in rats following oral administration for 7 days. Liver injury was induced in rats following oral administration of PCM overdose. Hepatic biomarkers; alanine-aminotransferase, aspartate-aminotransferase, alkaline-phosphatase, γ-glutamyl transferase and bilirubin were increased, while total protein and albumin were reduced in PCM control animals. Additionally, the activities of superoxide dismutase (SOD), catalase and glutathione-peroxidase (GPx) and the levels of glutathione were significantly declined, while levels of hepatic malondialdehyde (MDA) were significantly elevated in PCM alone treated rats. Oral administration of A. davisii (400 mg/kg) prior to PCM inhibited the elevation in the levels of liver damage markers in serum and protected against oxidative stress. Histopathological remarks confirmed the hepatoprotective potential of the extract. The results suggest that A. davisii extract at 400 mg/kg protects liver against injury induced by PCM overdose.

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Section: Estimation Of In Vitro Antioxidant Effectsupporting

confidence: 73%

Section: Hepatoprotective Activitysupporting

confidence: 56%

The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats

Foudah

Alqarni

Soliman

et al. 2020

JPRI

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“…Their increase in serum is roughly proportional to the extent of liver damage [7]. The significant ( P < 0.05) elevation of ALT, AST, and ALP was noticeable at higher doses.…”

Section: Discussionmentioning

confidence: 99%

“…The ethanol leaf extract has been shown to normalize renal oxidative stress and lipid peroxidation in diabetic rats [6]. Also, the leaf extract has hepatoprotective effect against acetaminophen [7]. The hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidant activities of the leaf extract have all been reported [8–10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antioxidant, Immunomodulatory Activities, and Safety of Ethanol Extract and Fractions of Gongronema latifolium Fruit

Agwaramgbo

Ilodigwe

Ajaghaku

et al. 2014

International Scholarly Research Notices

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Gongronema latifolium fruit has wide application in ethnomedicine, especially in maintaining healthy living and general body healing. We therefore investigated the antioxidant, immunomodulatory activities, and safety of its ethanol extract and fractions. The in vitro antioxidant activities of the extract and fractions were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) test while in vivo activities were determined using carbon tetrachloride (CCL4) induced oxidative stress. Cell and humoral mediated immune responses were also evaluated together with toxicity studies. The extract, ethyl acetate, and methanol fractions showed inhibition of DPPH radical with IC50s 120, 90, and 60 μg/mL, respectively. Methanol fraction at 200 mg/kg produced significant (P < 0.05) inhibition of lipid peroxidation (MDA conc. 1.2 μmol/L) compared to control (2.8 μmol/L). Both ethyl acetate and methanol fractions at 200 mg/kg produced significant (P < 0.05) phagocytic index of 0.021 and 0.025, respectively, compared with control (0.01). Significant (P < 0.05) elevations of white blood cells, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were noticed on the 91st day at higher doses. Generally, this study justified the traditional use of G. latifolium fruit for general body healing and maintenance of healthy living. Long term administration is safe on the haematological and biochemical systems especially at lower doses and its toxicity at higher doses is reversible.

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“…(Asclepiadaceae) (GL) is widespread in the tropical and subtropical regions of Africa. It is known to the natives as “Utazi” and “Arokeke” in south eastern and south western Nigeria, respectively [1, 2]. It is also found in South America, and has moderate representation in north and south east Asia [3]Gongronema latifolium has long been recognized as an African traditional remedy for a variety of ailments, such as hypertension, diabetes mellitus, malaria, mental and intestinal disorders [1, 4].…”

Section: Introductionmentioning

confidence: 99%

Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

Al-Hindi

Yusoff

Ahmad

et al. 2019

BMC Complement Altern Med

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Background The leaves of Gongronema latifolium Benth. have long been recognized traditionally as a remedy for a variety of ailments in Africa. This study was conducted to evaluate the safety profile of the ethanolic extract of G. latifolium (GLES) leaves through a repeated dose 90-day oral toxicity study in male and female of Sprague Dawley rats. Methods GLES was orally administered at doses of 250, 500 and 1000 mg/kg/day consecutively for 90 days. Results No behavioral or physiological changes and mortality were observed. GLES did not have a marked impact on general hematological parameters and did not precipitate nephrotoxicity. However, compared to the control, serum triglycerides, total cholesterol and low-density lipoprotein levels were lower and white adipose tissue paired retroperitoneal fat depots were depleted in male rats treated with GLES3 by the end of the experiment. The liver was significantly enlarged in GLES-treated rats of both sexes. Negative gender-specific alterations were observed with the highest dose. Adverse risk was evident in the female rats mainly due to marked body weight gain and cerebrum weight reduction. Conclusion Further research is needed to reach more specific conclusions about to the safety of ingesting high doses of GLES for long periods of time.

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The protective role of Gongronema latifolium in acetaminophen induced hepatic toxicity in Wistar rats

Cited by 21 publications

References 23 publications

The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats

The Potential Hepatoprotective and Antioxidant Activities of Astragalus davisii against Paracetamol Induced Liver Damage in Rats

Evaluation of Antioxidant, Immunomodulatory Activities, and Safety of Ethanol Extract and Fractions of Gongronema latifolium Fruit

Safety assessment of the ethanolic extract of Gongronema latifolium Benth. leaves: a 90-day oral toxicity study in Sprague Dawley rats

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