The protective role of phloretin against dextran sulfate sodium-induced ulcerative colitis in mice

Zhang, Zecai; Li, Shan; Cao, Hongshi; Shen, Peng; Liu, Jiuxi; Fu, Yunhe; Cao, Yongguo; Zhang, Naisheng

doi:10.1039/c8fo01699b

Cited by 114 publications

(72 citation statements)

References 41 publications

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“…Similar to a previously study, we noticed that the DSS treatment caused mucosal barrier losses as well as inflammation in the intestinal epithelial cells, resulting in diarrhea and shortened colons in the mice [23]. Flavonoids, including galangin have good anti-inflammatory activity, and some specific flavonoids, such as pinocembrin [16], naringenin [24], and phloretin [25] have been demonstrated to have good anti-colitis effects. However, other flavonoids, such as luteolin, can aggravate DSS-induced experimental colitis, suggesting that the mechanisms of action associated with flavonoids are quite complex [26].…”

Section: Discussionsupporting

confidence: 86%

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

Han

Hao

et al. 2020

Nutrients

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Galangin is a natural flavonoid that has been reported to provide substantial health benefits. Nevertheless, little is known about the potential effects of galangin against inflammatory bowel diseases. Here, an in vivo study was performed to investigate the preventive effects of galangin against dextran sulphate sodium (DSS)-induced acute murine colitis, which mimics the symptoms of human ulcerative colitis (UC). Pre-treatment with galangin (15 mg/kg, p.o.) resulted in a significant decreased in the macroscopic signs of DSS-induced colitic symptoms, including a decreased disease activity index, prevention of the colon length shortening, and alleviation of the pathological changes occurring in the colon. Colonic pro-inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, as well as myeloperoxidase activities were decreased following galangin pre-treatment when compared with the DSS control group. Moreover, galangin pre-treatment significantly increased the expressions of autophagy-related proteins and promoted the formation of autophagosome in the colon. Galangin pre-treatment increased the diversity of the gut microbiota, and this was accompanied by increased levels of short-chain fatty acids. These observed changes could involve the modulating effects conferred by galangin in relation to some specific bacteria populations, including the recovery of Lactobacillus spp., and increased Butyricimonas spp. Overall, these results support the use of galangin in the prevention of UC.

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Section: Discussionsupporting

confidence: 86%

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

Han

Hao

et al. 2020

Nutrients

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“…Excessive inflammation augments oxidative stress, which has been associated with extensive infiltration of immune cells, and activation of NF-κB signaling and ER stress, thereby causing tissue damage and exacerbation of a patient’s condition [ 12 , 32 , 33 ]. As shown in Figure 6 , DSS significantly enhanced the MDA level, but downregulated the enzyme activity of GPx and CAT.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

Han

Wang

et al. 2020

Marine Drugs

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“…Occludin was involved in regulating 'leak pathway', whose decreased expression and abnormal distribution result in increased permeability of monolayer intestinal epithelial cells (57). ZO-1 is one of the important components of the tight junction, which attaches Claudin and Occludin proteins to the cytoskeletonis, and often used as an indicator of intestinal inbarrier function (58). Our present results showed that AAP1 could significantly increase the level of Claudin-1, Occludin and ZO-1, suggesting that AAP1 could effectively restore intestinal barrier functions.…”

Section: Discussionmentioning

confidence: 99%

Effects of Polysaccharides From Auricularia auricula on the Immuno-Stimulatory Activity and Gut Microbiota in Immunosuppressed Mice Induced by Cyclophosphamide

Kong

Duan

et al. 2020

Front. Immunol.

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Recently, the immuno-enhancing potential of polysaccharide from Auricularia auricula (AAP) has been an area of research interest. However, the immune-stimulatory activity and mechanisms of AAP in immunosuppressive mice treated with cyclophosphamide (CTX) are still poorly understood. This study aimed to evaluate the immuno-enhancing effects of AAP and mine its possible mechanisms. Firstly, polysaccharides were isolated from A. auricula and purified. Secondly, the immune-stimulatory activities of the first AAP fraction (AAP1) were evaluated in the CTX-treated mice. Results showed that AAP1 significantly enhanced immune organ indexes, remarkably stimulated IFN-g, IL-2, IL-4, IL-10, and TNF-a levels in the serum, and dramatically up-regulated the mRNA levels of Claudin-1, Occludin and ZO-1. Compared to the CTX group, AAP1 administration restored the gut microbiota composition similar to that of the control group by decreasing the ratio of Firmicutes/Bacteroidetes and increasing the relative abundances of short-chain fatty acid-producing microbiota. This study provides useful information for its further application as an immune-stimulator in foods and drugs.

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The protective role of phloretin against dextran sulfate sodium-induced ulcerative colitis in mice

Abstract: Oral administration of phloretin, mainly found in apples and strawberries, ameliorates ulcerative colitis in mice.

Cited by 114 publications

References 41 publications

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

Characterization of Low Molecular Weight Sulfate Ulva Polysaccharide and its Protective Effect against IBD in Mice

Effects of Polysaccharides From Auricularia auricula on the Immuno-Stimulatory Activity and Gut Microbiota in Immunosuppressed Mice Induced by Cyclophosphamide

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