The Protective Role of Wheat Germ Oil Against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats

Abstract

Deltamethrin (DLM) is a synthetic pyrethroid type-II known to cause many adverse effects in experimental animals such as endocrine disruption, reproductive toxicity, and negative impact on gametogenesis. The present study was conducted to evaluate the protective role of wheat germ oil against reproductive toxicity induced by Deltamethrin (DLM) in male albino rats through evaluation of semen picture, measuring the testosterone levels, DNA fragmentation percentage and pathologic changes of the testes. Thirty male rats were divided into three groups (10 each); the first group (C) was administered with normal saline, the second group was given (DLM) at a dose of (6 mg/kg. B.W. of rats) and the third group (DLM+WGO) was treated with wheat germ oil (1.5 ml/Kg. B.W. of rats), and after one h DLM (6 mg/kg. B.W. of rats) was administered. All treatments were orally given using stomach gavage for 30 days. The rats were left for 65 days of treatment to complete time of one spermatogenesis and maturation of sperms in epididymis then sacrificed and blood samples were collected, testes and epididymis were removed, weighted, and examined histopathologically. DLM administration significantly decreased the weight of testes and adversely affected the semen quality. Testosterone levels were significantly reduced. There is a significant elevation in the DNA laddering percentage in the DLM group compared to the C group. Histopathological examination of the testes revealed that DLM induced changes in the form of distorted seminiferous tubules with intraluminal sloughing degenerated spermatogenic cells. Also there is marked interstitial edema and congestion. The co-administration of DLM with wheat germ showed improvement in weight of testes, semen pictures, testosterone level and a significant reduction in the DNA laddering percentage compared to DLM group. It can be concluded that, the wheat germ oil can mitigate the adverse effects of DLM on male fertility, and leads to improvement of male reproductive performance.

Evaluation of the Effect of Wheat Germ Oil and Olmutinib on the Thioacetamide-Induced Liver and Kidney Toxicity in Mice

“…This study reports WGO as a protective agent against liver and kidney damage in mice. Previous studies showed the protective effects of WGO against streptozotocin, deltamethrin, and chlorpyriphos [45,46]. To the best of our knowledge, no study reported that the supplementation of WGO might be a promising strategy for managing or decreasing the side effects of chemotherapeutic drugs such as olmutinib and TAA.…”

Some Semen Characteristics and Oxidant/Antioxidant Markers of Chilled Diluted Rabbit Semen in Tris-Based Extender Supplemented with Wheat Germ Extracts

“…The WG oil had its powerful effect in rising the reproductive traits of Sinaii gabali rabbit bucks especially on conception rate%, the gestation length of does inseminated with semen of rabbit fed wheat germ oil, also the litter size at birth and weaning, the litter weight at birth and weaning, and decreasing the mortality rate at weaning [15]. The WG oil can mitigate the adverse effect of pollutants on male fertility, and leads to improvement of male reproductive performance [16]. Donoghue and Walker-Simmons [17] reported that the supply of 10% wheat protein extract to semen stored 24 h at 5°C enhanced fertility and hatchability of eggs over semen stored in diluent alone (P<0.05).…”