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Deltamethrin (DLM) is a synthetic pyrethroid type-II known to cause many adverse effects in experimental animals such as endocrine disruption, reproductive toxicity, and negative impact on gametogenesis. The present study was conducted to evaluate the protective role of wheat germ oil against reproductive toxicity induced by Deltamethrin (DLM) in male albino rats through evaluation of semen picture, measuring the testosterone levels, DNA fragmentation percentage and pathologic changes of the testes. Thirty male rats were divided into three groups (10 each); the first group (C) was administered with normal saline, the second group was given (DLM) at a dose of (6 mg/kg. B.W. of rats) and the third group (DLM+WGO) was treated with wheat germ oil (1.5 ml/Kg. B.W. of rats), and after one h DLM (6 mg/kg. B.W. of rats) was administered. All treatments were orally given using stomach gavage for 30 days. The rats were left for 65 days of treatment to complete time of one spermatogenesis and maturation of sperms in epididymis then sacrificed and blood samples were collected, testes and epididymis were removed, weighted, and examined histopathologically. DLM administration significantly decreased the weight of testes and adversely affected the semen quality. Testosterone levels were significantly reduced. There is a significant elevation in the DNA laddering percentage in the DLM group compared to the C group. Histopathological examination of the testes revealed that DLM induced changes in the form of distorted seminiferous tubules with intraluminal sloughing degenerated spermatogenic cells. Also there is marked interstitial edema and congestion. The co-administration of DLM with wheat germ showed improvement in weight of testes, semen pictures, testosterone level and a significant reduction in the DNA laddering percentage compared to DLM group. It can be concluded that, the wheat germ oil can mitigate the adverse effects of DLM on male fertility, and leads to improvement of male reproductive performance.

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EnAbstract Background Cortical auditory evoked potentials (CAEPs) are noninvasive measures used to quantify central auditory system function in humans. More specifically, the P1–N1–P2 cortical auditory evoked potential has a unique role in identifying the central auditory system that has benefited from amplification or implantation. P1 reflects the maturation of the auditory system in general as it has developed over time. Objective The aims of this study were to assess the CAEP in children with cochlear implants compared with age-matched controls, to study the different variables affecting the results, and to compare the pattern of P1 CAEP in cochlear implant patients compared with that in those with hearing aids. Methodology Thirty-five hearing-impaired children (using cochlear implants) were compared with 20 age-matched and sex-matched children with normal hearing. In both groups, P1 CAEP latency and waveform morphology were recorded using free-field auditory stimulation with tone bursts at 500 and 2000 Hz at 100 dB sound pressure level in two sessions that were 6 months apart. Results Children using cochlear implants exhibited prolongation of P1 latencies, indicating an overall delay in maturation when compared with that in children who could hear normally. P1 CAEP latency and amplitude improved significantly after 6 months of device use. Conclusion Standardized age-appropriate normative data on P1 CAEPs in the pediatric Egyptian population could be used to determine implantation or amplification results.